Dr Jennifer Mitchell BA (Mod) PhD
Contact Details
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Biography:
| 2009 - Present Lecturer in Infection Biology, University College Dublin 2004 - 2009 Postdoctoral Fellow, University of California San Francisco 2006 Postdoctoral Teaching Fellow, San Francisco State University 2004 Postdoctoral Fellow, University of Dublin, Trinity College1999 - 2004 PhD in Microbiology, University of Dublin, Trinity College 1995-1999 BA (Mod) Microbiology, University of Dublin, Trinity College |
Research Interests
| Current research in my lab is concerned with analysing the interaction of commensal and pathogenic streptococci and staphylococci with glycoproteins and glycolipids on the surface of host cells. Analysis of this interaction will help us to understand how these bacteria make the transition from a commensal to a pathogenic state. |
Research Projects
| Sponsor : University College Dublin (UCD) Title : M.Sc. Biotechnology research supervision Start Date / End Date : 06-MAY-11 / 07-MAY-12 |
| Sponsor : Health Research Board (HRB) Title : Developing Inhibitors of Mucosal Colonisation by Gram Positive Pathogens Start Date / End Date : 01-AUG-12 / 31-JUL-13 |
| Sponsor : EC Framework Title : The role of glycoprotein CD36 as a platelet receptor for Streptococci and Staphylococci (MITISCD36LTA) Start Date / End Date : 01-SEP-10 / 31-AUG-12 |
| Sponsor : Teagasc Title : Genetic and Molecular Mechanisms of Pathogenesis in mastitis-causing Staphylococcus aureus Start Date / End Date : 01-OCT-10 / 30-SEP-14 |
| Sponsor : University College Dublin (UCD) Title : Glycoprotein CD36 (GPIV) is a Platelet Receptor for Streptococcus mitis Lipoteichoic Acid. Start Date / End Date : 17-MAY-10 / 16-NOV-11 |
| Sponsor : University College Dublin (UCD) Title : The interaction of Streptococcus mitis with CD36 Start Date / End Date : 01-SEP-09 / 31-AUG-12 |
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Peer Reviewed Journals
| Nallapareddy, SR,Sillanpaa, J,Mitchell, J,Singh, KV,Chowdhury, SA,Weinstock, GM,Sullam, PM,Murray, BE; (2011) 'Conservation of Ebp-Type Pilus Genes among Enterococci and Demonstration of Their Role in Adherence of Enterococcus faecalis to Human Platelets'. Infection and immunity, 79 :2911-2920. [DOI] [Details] |
| Jennifer Mitchell; (2011) 'Streptococcus mitis: Walking the line between commensalism and pathogenesis'. Molecular Oral Microbiology, 26 :1-10. [Details] |
| Seo H, Xiong YQ, Mitchell J, Seepersaud R, Bayer AS and PM Sullam.; (2010) 'Bacteriophage lysin mediates the binding of Streptococcus mitis to human platelets through interaction with fibrinogen'. PLoS pathogens, 6 (8). [Details] |
| Kwiecinski J, Josefsson E, Mitchell J, Higgins J, Magnusson M, Foster T, Jin T and Bokarewa M. ; (2010) 'Activation of plasminogen by staphylokinase reduces severity of Staphylococcus aureus systemic infection'. Journal of Infectious Diseases, . [Details] |
| Mitchell J and Sullam P; (2009) 'Streptococcus mitis phage-encoded adhesins mediate attachment to a-2,8-linked sialic acid residues on platelet membrane gangliosides'. Infection and Immunity, 77 (8):3485-3490. [Details] |
| Mitchell J, Siboo IR, Takamatsu D, Chambers H and Sullam P. Mechanism ; (2007) 'Mechanism of cell surface expression of the Streptococcus mitis platelet binding proteins PblA and PblB'. Molecular Microbiology, 64 (3):844-857. [Details] | |||||||||
| Mitchell J, Tristan A and Foster TJ. ; (2004) 'The fibrinogen binding protein Fbl of Staphylococcus lugdunensis '. Microbiology, 150 (11):3831-3841. [Details] | |||||||||
| Jin T, Bokarewa M, Foster T, Mitchell J, Higgins J and Tarkowski A. ; (2004) 'Staphylococcus aureus resists human defensins by production of staphylokinase, a novel bacterial evasion mechanism'. Journal of Immunology, 172 (2):1169-1176. [Details] | |||||||||
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Conference Publications
| Jennifer Mitchell (2012) CD36 is a Platelet Receptor for Bacterial Pathogens International Cardiovascular Infection Symposium, Society for General Microbiology Spring Conference [Details] |
| A Murray and J Mitchell; (2011) Characterization of the Interaction of Staphylococcus aureus with the Human Membrane receptor CD36 on the surface of platelets Staph GBI (Great Britain & Ireland) 2011 Conference [Details] |
| Murray A and Mitchell J; (2011) CD36 is a receptor for the adherence of Gram positive pathogens to platelets 6th International Conference on Gram-positive Microorganisms, Italy [Details] |
| Mitchell J and Sullam P. ; (2009) Streptococcus mitis phage-encoded adhesins mediate attachment to 2-8 linked sialic acid residues on platelet membrane gangliosides 5th International Conference on Gram-positive Microorganisms San Diego, [Details] |
| Mitchell J and Sullam P. ; (2008) Streptococcus mitis adheres to sialylated residues on human platelets Society for General Microbiology 163rd Meeting [Details] |
| Mitchell J, Siboo IR, Takamatsu D, Chambers H and Sullam P. ; (2007) Mechanism of cell surface expression of the Streptococcus mitis platelet binding proteins PblA and PblB Bay Area Microbial Pathogenesis Symposium [Details] | |||||||||
| Mitchell J, Siboo IR and Sullam P. ; (2007) The Streptococcus mitis Platelet Binding Adhesins PblA and PblB are Anchored to the Cell Surface via Choline Binding Domains American Society for Microbiology. 107th General Meeting Toronto, [Details] | |||||||||
| Mitchell J, Siboo IR, Takamatsu D, and Sullam P. Bacterial ; (2006) Bacterial Altruism: A lysis-reuptake mechanism for the cell surface expression of the S. mitis platelet binding proteins PblA and PblB ASM Symposium on Streptococcal Genetics Saint Malo, France, [Details] | |||||||||
| Mitchell J, Siboo IR, Takamatsu D, and Sullam P. ; (2006) Bacterial Altruism or the Selfish Phage: A lysis-reuptake mechanism for the cell surface expression of the S. mitis platelet binding proteins PblA and PblB Cold Spring Harbor Laboratory Meeting, Molecular Genetics of Bacteria and Phages [Details] | |||||||||
| Mitchell J, Siboo IR, Takamatsu D, Sullam P. ; (2005) A lysis-reuptake mechanism for the cell surface expression of the S. mitis platelet binding proteins PblA and PblB Cold Spring Harbor Laboratory Meeting, Microbial Pathogenesis and Host Response [Details] | |||||||||
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Associations
| Association: American Society for Microbiology , Function/Role: Member |
| Association: Society for General Microbiology , Function/Role: Member |
Committees
| Committee : UCD Infection Biology Committee |
Internal Collaborators
| Dr. James O'Gara Dr. Stephen Gordon |
External Collaborators
| Dr. Paul Sullam, University of California San Francisco Dr. James Smyth, University of California San Francisco Dr. Samy Lamouille, University of California San Francisco Dr. Orla Keane, Teagasc |
Teaching Philosophy
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VET20180: Introduction to One Health VET40080: Advances in Infection Biology VET40100: Current Concepts in Infection Biology B VET40090: Current Concepts in Infection Biology A VET30030: Introduction to Veterinary Microbiology MICR40010: Recombinant DNA Technology |
Modules Coordinated
| 201100 VET40090 Veterinary Medicine: Concepts Infection Biology A |