Dr Patricia Maguire BSc, PhD
Contact Details
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Biography:
| Platelet, Proteomics, Mass spectrometry, Signalling pathways, Wnt, Heart Disease, Cardiovascular Disease, Bloodomics, EU FP7, Conway |
Research Interests
| Our research interests centre on the application of proteomics to disease characterization and identification of drug targets. Platelets are known to play an important role in cardiovascular diseases and stroke however, current tests cannot predict platelet function or guide clinical therapy. Platelet aggregation and secretion assays from platelets have generated a wealth of information but these are complex processes, and platelets may be activated by different agonists utilizing multiple pathways. We apply proteomic technologies to the analysis of whole platelets, platelet subfractions as well as studying platelets from groups of patients in whom functional changes are suspected. We also specialise in applying immunoprecipitations to mass spectrometry and have a number of successful collaborations in this area. One outcome of such studies is the observation that platelets express proteins which are integral to many previously unattributed signalling pathways and we are currently investigating the activity of these pathways in platelets and megakaryocytes.
EU FP7 Marie Curie Training Network IRCSET |
Books
| Maguire PB, Belton O, O¿Donoghue N & Coppinger JC.; (2007) Platelet-endothelial interactions in, The Endothelium: A Comprehensive Reference. Cambridge, UK: Cambridge Univerity Press. [Details] |
Book Chapters
| Maguire PB, Belton O, O'Donoghue N & Coppinger JC. ; (2006) 'Platelet-endothelial interactions' In: Aird, W.C (eds). The Endothelium: A Comprehensive Reference. Cambridge, UK: Cambridge Univerity Press. [Details] |
Peer Reviewed Journals
| 2. Goodall AH, Burns P , Salles I, Macaulay IC, Jones C, Ardissino D, de Bono B, Bray SL, Deckmyn H, Dudbridge F, Fitzgerald DJ, Garner SF, Gusnanto A, Koch K, Langford C, O¿Connor M, Rice CM, van der Schoot E, Stemple D, Stephens J, Trip MD, Samani NJ, Watkins NA, Maguire PB, Ouwehand WH; (2010) 'Transcription Profiling in Human Platelets Reveals LRRFIP1 as a Novel Protein Regulating Platelet Function'. Blood, . [Details] |
| Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB; (2009) 'Canonical Wnt signaling negatively regulates platelet function'. Proceedings of the National Academy of Sciences USA, 106 (47):19836-19841. [Details] |
| Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD. ; (2009) 'Differential stimulation of monocytic cells results in distinct populations of microparticles'. Journal of Thrombosis and Haemostasis, 7 (6):1019-1028. [DOI] [Details] |
| O Riordan A., Johnston O., McMorrow T., Wynne K., Maguire P., Hegarty J.E., McCormick A., Watson A.J., Cagney G., Gallagher W.M. and Ryan M.P. ; (2008) 'Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques'. Proteomics Clinical Applications, 2 (8):1338-1348. [Details] |
| Feighery, R., Maguire, P., Ryan, M. R., McMorrow, T., ; (2008) 'A proteomic approach to immune-mediated epithelial-mesenchymal transition'. Proteomics Clinical Applications, 2 (7-8):1110-1117. [Details] |
| Behan AT, Foy M, Wynne K, Clarke M, Sullivan M, Cotter DR, Maguire PB; (2007) 'Analysis of membrane microdomains-associated proteins in the insular cortex of human brain'. Proteomics Clinical Applications, 1 :1324-1331. [Details] | |||||||||
| Coppinger, JA,O'Connor, R,Wynne, K,Flanagan, M,Sullivan, M,Maguire, PB,Fitzgerald, DJ,Cagney, G; (2007) 'Moderation of the platelet releasate response by aspirin'. Blood, 109 :4786-4792. [DOI] [Details] | |||||||||
| Kerrigan SW, Jakubovics NS, Keane C, Maguire P, Wynne K, Jenkinson HF, Cox D. ; (2007) 'Role of Streptococcus gordonii surface proteins SspA/SspB and Hsa in platelet function'. Infection and Immunity, 75 (12):5740-5747. [Details] | |||||||||
| Coppinger, J., Fitzgerald, D. J., Maguire, P. B.; (2007) 'Isolation of the platelet releasate'. Methods in Molecular Biology, 357 :307-11. [Details] | |||||||||
| Maguire PB, Foy M, ; (2007) 'Recent advances in the characterisation of the platelet membrane system by proteomics'. Current Pharmaceutical Design, 13 (26):2647-2655. [Details] | |||||||||
| Foy M., Harney D.F, Wynne K.J & Maguire P.B; (2007) 'Enrichment of phospho-tyrosine proteome of human platelets by immunoprecipitation'. Methods in Molecular Biology, . [Details] | |||||||||
| Fitzgerald DJ, Maguire PB, Foy M, ; (2005) 'Using proteomics to identify potential therapeutic targets in platelets'. Biochemical Society Transactions, 33 (Pt 2):409-412. [DOI] [Details] | |||||||||
| Kelly P, Maguire PB, Bennett M, Fitzgerald DJ, Edwards RJ, Thiede B, Treumann A, Collins JK, O'sullivan GC, Shanahan F, Dunne C. ; (2005) 'Correlation of probiotic Lactobacillus salivarius growth phase with its cell wall-associated proteome'. Fems Microbiology Letters, 252 (252):153-159. [Details] | |||||||||
| Coppinger J.A., Cagney G., Toomey S., Kislinger T., Belton O., McRedmond J., Cahill D., Emili A., Fitzgerald D.J. & Maguire P.B. ; (2004) 'Proteomic characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions'. Blood, 103 :2096-2104. [Details] | |||||||||
| McRedmond J., Park S., Reilly, D., Coppinger J.A., Maguire, P.B., Shields, D. & Fitzgerald D.J. ; (2004) 'Integration of transcriptomics and genomics in platelets: a profile of platelet proteins and platelet-specific genes'. Molecular and Cellular Proteomics, 3 :133-144. [Details] | |||||||||
| Maguire PB, Moran N, Cagney G, Fitzgerald DJ.; (2004) 'Application of proteomics to the study of platelet regulatory mechanisms'. Trends in cardiovascular medicine, 6 (NA):207-220. [DOI] [Details] | |||||||||
| Maguire PB, ; (2003) 'Platelet proteomics: identification of potential therapeutic targets'. Pathophysiology of haemostasis and thrombosis, 33 (5-6):481-486. [DOI] [Details] | |||||||||
| Maguire P.B. & Fitzgerald D.F; (2003) 'Platelet proteomics'. Journal of Thrombosis and Haemostasis, 1 :1593-1601. [Details] | |||||||||
| Maguire P.B., Wynne, K.J., Harney, D.F., O'Donoghue, N.M., Stephens, G. & Fitzgerald, D.J. ; (2002) 'Identification of the phosphotyrosine proteome from thrombin activated platelets'. Proteomics, 2 :642-648. [Details] | |||||||||
| Ohlendieck, K; Fromming, GR; Murray, BE; Maguire, PB; Leisner, E; Traub, I; Pette, D; ; (1999) 'Effects of chronic low-frequency stimulation on Ca2+-regulatory membrane proteins in rabbit fast muscle'. Pflugers Archiv-European Journal of Physiology, 438 (5):700-708. [Details] | |||||||||
| Culligan, KG; Mackey, AJ; Finn, DM; Maguire, PB; Ohlendieck, K; ; (1998) 'Role of dystrophin isoforms and associated proteins in muscular dystrophy (Review)'. International Journal of Molecular Medicine, 2 (6):639-648. [Details] | |||||||||
| Murray, BE; Froemming, GR; Maguire, PB; Ohlendieck, K; ; (1998) 'Excitation-contraction-relaxation cycle: Role of Ca2+-regulatory membrane proteins in normal, stimulated and pathological skeletal muscle (Review)'. International Journal of Molecular Medicine, 1 (4):677-687. [Details] | |||||||||
| Ohlendieck K, Maguire PB, Briggs FN, Lennon NJ, ; (1997) 'Oligomerization is an intrinsic property of calsequestrin in normal and transformed skeletal muscle'. Biochemical and Biophysical Research Communications, 240 (3):721-727. [DOI] [Details] | |||||||||
| Maguire, PB, Ohlendieck, K, ; (1996) 'Oligomerization of sarcoplasmic reticulum Ca2+-ATPase from rabbit skeletal muscle'. FEBS Letters, 396 (2-3):115-118. [Details] | |||||||||
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Conference Publications
| Fitzgerald DJ, Maguire PB, Foy M, ; (2005) Biochemical Society transactions Using proteomics to identify potential therapeutic targets in platelets , pp.409-412 [DOI] [Details] |
| Foy, M, Treumann, A, Fitzgerald, DJ, Maguire, PB, Kerrigan, SK, ; (2004) BLOOD Characterization of platelet lipid rafts leads to the identification of RGS-19, which forms a phosphorylation-dependent complex with 14-3-3 xi , pp.181-181 [Details] |
| Ohlendieck K, Maguire PB, Lennon NJ, ; (1998) Biochemical Society transactions Oligomerisation of calsequestrin from rabbit skeletal muscle [Details] |
Education
| Year 1999 Institution: University College Dublin Qualification: PhD Subject: |
| Year 1995 Institution: University College Dublin Qualification: BSc Subject: |
Internal Collaborators
| Dr. Orina Belton, Conway Institute, UCD. |
External Collaborators
| Prof. Raymond Habas, Temple University, PA, USA. |
Teaching Interests
Recent Postgraduates
| Dr Brian Steele PhD 2010 Dr Martina Foy- PhD 2005 Dr Donal Harney- MD 2005 Dr Judith Coppinger- PhD 2004 |
Current Postgraduate Students
| Naheda Alkazemi, Doctor of Philosophy (PhD) - Thesis Supervisor |
| Vishal Salunkhe, Doctor of Philosophy (PhD) - Thesis Supervisor |
Modules Taught
| 201000 BMOL10020 Biomolecular & Biomed Science: The Science of Human Disease |
| 200800 BIOC10040 Biochemistry: Modern Topics in Biochemistry & Molecular Biology |