Professor Steffen Backert PhD
Contact Details
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Biography:
| 2008 - Present Professor of Cellular Microbiology, UCD 2003-2008 Research Group Leader, Otto von Guericke University, Magdeburg, Germany. 1997-2003 Group Leader, Max Planck Institute for Infection Biology, Berlin, Germamy. Conway, Helicobacter pylori, Campylobacter jejuni, EPEC, type IV secretion, type III secretion, cellular microbiology, infection, signalling, signaling, integrin, CagA, CagL, conjugation, DNA transfer |
Research Interests
Book Chapters
| Backert, S., Dobrindt, U.; (2008) 'Clinical Presentations and Pathogenicity of Foodborne Diseases' In: O.A. Oyarzabal (eds). Food Safety Concepts. Germany: Springer Verlag. [Details] |
| Backert, S. Konig, W., Arnold, R., Konig, B.; (2006) 'Induction and Modulation of Inflammatory Networks by Bacterial Protein Toxins' In: J.E. Alouf, M.R. Popoff (eds). The Sourcebook of Bacterial Protein Toxins. New York: Academic Press. [Details] |
| Backert, S., Moyer, P, Bohm, C., Riecken, E.O., Hanski, C.; (1998) 'Differential Gene Expression in Cell Lines Dervied from Coloin Carcinoma or Normal Colonic Mucosa' In: Jahrbuch der 8. Wissenschaftswoche an der FU-Berlin. Berlin: -. [Details] |
| Backert, S.; (1996) 'Untersuchungen zur Struktur und Replikation des Mitochondriengenoms von' In: Chenopodium Album. Aachen: Shaker-Verlag. [Details] |
Peer Reviewed Journals
| Tegtmeyer, N,Wittelsberger, R,Hartig, R,Wessler, S,Martinez-Quiles, N,Backert, S; (2011) 'Serine Phosphorylation of Cortactin Controls Focal Adhesion Kinase Activity and Cell Scattering Induced by Helicobacter pylori'. Cell, 9 :520-531. [DOI] [Details] |
| Zhou, P,Hussain, SK,Liles, MR,Arias, CR,Backert, S,Kieninger, J,Oyarzabal, OA; (2011) 'A simplified and cost-effective enrichment protocol for the isolation of Campylobacter spp. from retail broiler meat without microaerobic incubation'. BMC microbiology, 11 . [DOI] [Details] |
| Oelkers, JM,Vinzenz, M,Nemethova, M,Jacob, S,Lai, FPL,Block, J,Szczodrak, M,Kerkhoff, E,Backert, S,Schluter, K,Stradal, TEB,Small, JV,Koestler, SA,Rottner, K; (2011) 'Microtubules as Platforms for Assaying Actin Polymerization In Vivo'. PLoS ONE, 6 . [DOI] [Details] |
| Backert, S,Clyne, M; (2011) 'Pathogenesis of Helicobacter pylori Infection'. Helicobacter, 16 :19-25. [DOI] [Details] |
| Saha, A,Backert, S,Hammond, CE,Gooz, M,Smolka, AJ; (2010) 'Helicobacter pylori CagL Activates ADAM17 to Induce Repression of the Gastric H, K-ATPase alpha Subunit'. Gastroenterology, 139 :239-248. [DOI] [Details] |
| Tegtmeyer, N,Hartig, R,Delahay, RM,Rohde, M,Brandt, S,Conradi, J,Takahashi, S,Smolka, AJ,Sewald, N,Backert, S; (2010) 'A Small Fibronectin-mimicking Protein from Bacteria Induces Cell Spreading and Focal Adhesion Formation'. Journal of Biological Chemistry, 285 :23513-23524. [DOI] [Details] | |||||||||
| Olofsson, A,Vallstrom, A,Petzold, K,Tegtmeyer, N,Schleucher, J,Carlsson, S,Haas, R,Backert, S,Wai, SN,Grobner, G,Arnqvist, A; (2010) 'Biochemical and functional characterization of Helicobacter pylori vesicles'. Molecular microbiology, 77 :1539-1555. [DOI] [Details] | |||||||||
| Hoy, B,Lower, M,Weydig, C,Carra, G,Tegtmeyer, N,Geppert, T,Schroder, P,Sewald, N,Backert, S,Schneider, G,Wessler, S; (2010) 'Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion'. Embo Reports, 11 :798-804. [DOI] [Details] | |||||||||
| Tegtmeyer, N., Zabler, D., Schmidt, D., Hartig, R., Brandt, S., Backert, S. ; (2009) 'Importance of EGF receptor, HER2/Neu and Erk1/2 kinase signaling for host cell elongation and scattering induced by the Helicobacter pylori0 CagA protein: antagonistic effects of the vacuolating cytotoxin VacA'. Cellular Microbiology, . [Details] | |||||||||
| Sason, H., Milgrom, M., Weiss, A.M., Melamed-Book, N., Balla, T., Grinstein, S., Backert, S., Rosenshine, I., Aroeti, B.; (2009) 'Enteropathogenic Escherichia coli0 subverts phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate upon epithelial cell infection'. Molecular Biology of the Cell, 20 :544-555. [Details] | |||||||||
| Backert, S., Selbach, M. ; (2008) 'Role of type IV secretion in Helicobacter pylori0 pathogenesis'. Cellular Microbiology, 10 :1573-1581. [Details] | |||||||||
| Knauer, O., Binai, N.A., Carra, G., Beckhaus, T., Hanschmann, K.M., Renné, T., Backert, S., Karas, M., Wessler, S. ; (2008) 'Differential phosphoproteome profiling reveals a functional role for VASP in Helicobacter pylori0 -induced cytoskeleton turnover in gastric epithelial cells'. Cellular Microbiology, 10 :2285-2296. [Details] | |||||||||
| Backert, S., Fronzes, R., Waksman, G.; (2008) 'VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems?'. Trends in Microbiology, 16 :409-413. [Details] | |||||||||
| Wessler, S., Backert, S.; (2008) 'Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori0'. Trends in Microbiology, 16 :181-189. [Details] | |||||||||
| Backert, S., Feller, S.M., Wessler, S.; (2008) 'Role of Abl family tyrosine kinases in microbial pathogenesis'. Trends in Biochemical Sciences, 33 :80-90. [Details] | |||||||||
| Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., Berger, J., Sewald, N., König, W., Backert, S. ; (2007) '\i Helicobacter pylori0 exploits integrin for type IV secretion and kinase0 activation'. Nature, 449 :862-866. [Details] | |||||||||
| Tammer, I., Brandt, S., Hartig, R., König, W., Backert, S. ; (2007) 'Activation of c-Abl kinase by Helicobacter pylori0 : a novel kinase of the CagA protein and crucial mediator of host cell scattering'. Gastroenterology, 132 :1309-1319. [Details] | |||||||||
| Krause, M., Rohde, M., Hartig, R., Genth, H., Miller, W.G., Schmidt, G., König, W., M.E. Konkel, Backert, S. ; (2007) 'Role of the small Rho GTPases Rac1 and Cdc42 in host cell invasion of Campylobacter jejuni0'. Cellular Microbiology, 9 :2431-2444. [Details] | |||||||||
| Backert, S., Meyer, T.F. ; (2006) 'Type IV secretion systems and their effector proteins in bacterial pathogenesis'. Current opinion in microbiology, 9 :207-217. [Details] | |||||||||
| Dossumbekova, A., Prinz, C., Gerhard, M., Brenner, L., Backert, S., Kusters, J.G., Schmid, R.M., Rad, R.; (2006) '\i Helicobacter pylori0 outer membrane proteins and gastric inflammation'. Gut, 55 :1360-1361. [Details] | |||||||||
| Brandt, S., Kwok, T., Hartig, R., König, W., Backert, S. ; (2005) 'NF-B-activation and potentiation of proinflammatory responses by the Helicobacter pylori0 CagA protein'. Proceedings of the National Academy of Sciences USA, 102 :9200-9205. [Details] | |||||||||
| Backert, S., Selbach, M. ; (2005) 'Tyrosine-phosphorylated microbial effector proteins: the enemies within'. Trends in Microbiology, 13 :476-484. [Details] | |||||||||
| Selbach, M., Backert, S. ; (2005) 'Cortactin: an Achilles´ heel of the actin cytoskeleton'. Trends in Microbiology, 13 :181-189. [Details] | |||||||||
| Selbach, M., Moese, S., Hauck, C.R., Meyer, T.F., Backert, S. ; (2003) 'The Helicobacter pylori0 CagA protein induces cortactin dephosphorylation and actin cytoskeletal rearrangements by inactivation of c-Src'. Embo Journal, 22 :515-528. [Details] | |||||||||
| Backert, S., Müller, E.-C., Jungblut, P.R., Meyer, T.F. ; (2001) 'Tyrosine phosphorylation patterns and size modification of the Helicobacter pylori0 CagA protein after translocation in gastric epithelial cells'. Proteomics, 1 :608-617. [Details] | |||||||||
| Backert, S., Moese, S., Selbach, M., Meyer, T.F. ; (2001) 'Phosphorylation of tyrosine 972 of the H. pylori0 CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells'. Molecular Microbiology, 42 :631-644. [Details] | |||||||||
| Backert, S., Ziska, E., Brinkmann, V., Zimny-Arndt, U., Fauconnier, A., Jungblut, P.R., Naumann, M., Meyer, T.F.; (2000) 'Translocation of the Helicobacter pylori0 CagA protein in gastric epithelial cells by a type IV secretion apparatus'. Cellular Microbiology, 2 :155-164. [Details] | |||||||||
| Gandhi, M., Hammett, L., Scissum-Gunn, K., Backert, S., Nielsen, B.L. ; (1998) 'Analysis of genome structure and gene copy number in Brassica campestris0 mitochondrial DNA'. FASEB Journal, 12 :261-262. [Details] | |||||||||
| Backert, S., von Nickisch-Rosenegk, E., Meyer, T.F. ; (1998) 'Potential role of two H. pylori0 relaxases in DNA transfer?'. Molecular Microbiology, 30 :673-674. [Details] | |||||||||
| Backert, S., Nielsen, B.L., Börner, T. ; (1997) 'The mystery of the rings: structure and replication of the mitochondrial genome in higher plants'. Trends in Plant Science, 2 :477-483. [Details] | |||||||||
| Backert, S., Meißner, K., Börner, T. ; (1997) 'Unique features of a mt rolling circle-plasmid mp1 from the higher plant Che0 nopodium album0 (L.)'. Nucleic Acids Research, 25 :582-590. [Details] | |||||||||
| Backert, S., Dörfel, P., Lurz, R., Börner, T. ; (1996) 'Rolling circle replication in the mitochondria of the higher plant Chenopodium album0 (L.)'. Molecular and Cellular Biology, 16 :6285-6294. [Details] | |||||||||
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Patents
| Patent GI 2538GRK : Transformation of mitochondria in higher plants |
| Patent PCT/EP00/10592 : Relaxase and other Vir proteins as targets for treatment of Helicobacter pylori infection and as DNA transfer system to mammalian cells |
| Patent - : Use of modulators of eukaryotic signal transduction pathways for treatment of Helicobacter pylori infections |
External Collaborators
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Teaching Interests
| Undergraduate Teaching I have been teaching since 1992, with primary teaching interests being:
I have also mentored an average of over 3 students per year during the past 6 years. Graduate Supervision I have supervised 13 PhD and 2 M.Sc. students. |