Dr Tadhg Ó'Cróinín PhD BA
Contact Details
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Biography:
2008-present Lecturer in the School of Biomolecular and Biomedical Science, University College Dublin 2004-2007 SFI Research Fellow, Department of Microbiology, Trinity College Dublin 2001-2003 Postdoctoral Research Fellow, National Institutes of Health, Bethesda, USA 1999-2000 EMBO Postdoctoral Fellowship, Vrije Universiteit, Amsterdam. 1995-1999 Ph.D. University College Dublin 1991-1995 B.A.mod Trinity College Dublin Tadhg O Croinin, Conway, Microbiology, Infection Biology, Gene Regulation, Campylobacter, Salmonella, Pathogenesis |
Research Interests
| My current research interest lies in the investigation of virulence gene regulation in bacterial pathogens during infection of the gastrointestinal tract. In particular I am interested in the role played by DNA supercoiling as a global regulator of virulence gene transcription in response to a variety of environmental signals which are encountered during the infectious cycle. My most recent work has characterised the pivotal role played by DNA supercoiling and histone like proteins during invasion of epithelial cells and survival within macrophages by Salmonella. |
Research Projects
| Sponsor : Science Foundation Ireland (SFI) Title : Characterisation of the role played by DNA supercoiling in the regulation of virulence genes of Campylobacter jejuni Start Date / End Date : 01-SEP-10 / 31-AUG-14 |
| Sponsor : University College Dublin (UCD) Title : The interaction of pathogenic organism with mucosal surfaces and epithelial cells Start Date / End Date : 26-MAY-08 / 01-DEC-09 |
Book Chapters
| Dorman C.J., O Croinin T, Mangan MW; (2007) 'Virulence gene regulation in Salmonella enterica serovar Typhimurium' In: Salmonella : Molecular Biology and Pathogenesis. United Kingdom: Horizon Press. [Details] |
Peer Reviewed Journals
| Mangan MW, Lucchini S, O Croinin T, Fitzgerald S, Hinton JC and Dorman CJ; (2011) 'The nucleoid-associated protein HU controls three regulons that coordinate virulence, response to stress and general physiology in Salmonella enterica serovar Typhimurium'. Microbiology, . [Details] |
| O Croinin T and Dorman C.J.; (2007) 'Expression of the Fis protein is sustained in late-exponential- and stationary-phase cultures of Salmonella enterica serovar Typhimurium grown in the absence of aeration'. MOLECULAR MICROBIOLOGY, 66 (1):237-251. [Details] |
| O Croinin T, McCormack A, van Vliet AH, Kusters JG and Bourke B; (2007) 'Random mutagenesis to identify novel Helicobacter mustelae virulence factors'. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 50 (2):257-263. [Details] |
| O Croinin T, Carroll R, Kelly A and Dorman C.J.; (2006) 'Roles for DNA supercoiling and the Fis protein in modulating expression of virulence genes during intracellular growth of Salmonella enterica serovar Typhimurium'. MOLECULAR MICROBIOLOGY, 63 (3):869-882. [Details] |
| Kelly A, Conway C, O Croinin T, Smith S.G.J. and Dorman C.J.; (2006) 'DNA supercoiling and the Lrp protein determine the directionality of fim switch DNA inversion in Escherichia coli K-12'. JOURNAL OF BACTERIOLOGY, 188 (15):5356-5363. [Details] |
| Mangan M, Lucchini S, Danino V, O Croinin T, Hinton J and Dorman CJ; (2006) 'THe integration host factor (IHF) regulon of Salmonella enterica serovar Typhimurium'. MOLECULAR MICROBIOLOGY, 59 (6):1831-1847. [Details] | |||||||||
| O Croinin T, Grippe V.K. and Merkel T.J.; (2005) 'Activation of the vrg-6 promoter of Bordetella pertussis by RisA'. JOURNAL OF BACTERIOLOGY, 187 (5):1648-1658. [Details] | |||||||||
| Forester N, Lumbsden J, O Croinin T, O'Toole P; (2001) 'Sequince and Antigenic Variability of the Helicobacter mustelae Surface Ring Protein Hsr'. INFECTION AND IMMUNITY, 69 :3447-3450. [Details] | |||||||||
| Clyne M, O Croinin T, Suerbaum S, Josenhans C and Drumm B; (2000) 'Adherence of Isogenic Flagellum Negative Mutants of Helicobacter pylori and Helicobacter mustelae to Human and Ferret Gastric Epithelial Cells'. INFECTION AND IMMUNITY, 68 :4335-4339. [Details] | |||||||||
| O Croinin T, Clyne M and Drumm B; (1998) 'Molecular Mimicry of Ferret Gastric Epithelial Blood Group Antigen A by Helicobacter mustelae'. GASTROENTEROLOGY, 114 :690-696. [Details] | |||||||||
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Conference Publications
| N. Corcionivoschi, A. Alemka, M. Clyne, T. O¿Croinin, B. Bourke; (2009) Host Derived Reactive Oxygen Species Modulate Bacterial Tyrosine Phosphorylation Pathway to Attenuate CPS Production in Campylobacter jejuni 81-176 during Infection of Human Epithelial Cells American Society of Microbiology : Annual General Meeting [Details] |
| Mangan M, Lucchini S, Danino V, O Croinin T, Hinton J and Dorman CJ; (2006) Three overlapping yet distinct integration host factor (IHF) regulons in Salmonella enterica serovar Typhimurium SGM Irish Branch Meeting : Mechanism of Bacterial Adhesion and Invasion [Details] |
| O Croinin T, Carroll R, Kelly A and Dorman C.J.; (2006) The role of Fis and DNA supercoiling during intracellular survival of Salmonella enterica serovar Typhimurium SGM Irish Branch Meeting : Mechanisms of Bacterial Adhesion and Invasion [Details] |
| O Croinin T, Grippe V.K. and Merkel T.J.; (2003) Analysis of the regulation of the virulence repressed genes of Bordetella pertussis by BvgR and RisA American Society of Microbiology : Annual General Meeting [Details] |
| O Croinin T, Grippe V.K. and Merkel T.J.; (2003) Analysis of the regulation of the virulence repressed genes of Bordetella pertussis by BvgR and RisA Mid-Atlantic Microbial Pathogenesis Meeting [Details] |
| O Croinin T, Grippe V.K. and Merkel T.J.; (2002) Analysis of the regulation of the virulence repressed genes of Bordetella pertussis by BvgR and RisA 7th International Symposium on Bordetella pertussis , Cambridge England [Details] | |||||||||
| O Croinin T, McCormack A, van Vliet AH, Kusters JG and Bourke B; (2000) Identification of Helicobacter mustelae Virulence Factors by Screening of a Random Insertional Mutant Library American Gastroenterology Association : Annual General Meeting [Details] | |||||||||
| O Croinin T, McCormack A, van Vliet AH, Kusters JG and Bourke B; (2000) Identification of Helicobacter mustelae Virulence Factors by Screening of a Random Insertional Mutant Library XIII International Workshop on Gastroduodenal Pathology and Helicobacter pylori, Rome, Italy [Details] | |||||||||
| Clyne M, O Croinin T and Drumm B; (1999) Adherence of Helicobacter pylori and Helicobacter mustelae to gastric cells studied using confocal microscopy American Society of Microbiology : Annual General Meeting [Details] | |||||||||
| O Croinin T, Clyne M, Appelmelk B, Claeys D and Drumm B; (1999) Presence of anti-gastric atuoantibodies in ferrets naturally infected with Helicobacter mustelae American Society of Microbiology : Annual General Meeting [Details] | |||||||||
| O Croinin T, Clyne M and Drumm B; (1997) Molecular mimicry of ferret gastric epithelial blood group antigen A by Helicobacter mustelae American Gastroenterology Association : Annual General Meeting [Details] | |||||||||
| O Croinin T, Clyne M and Drumm B; (1997) Helicobacter mustelae specific antibodies cross-react with ferret gastric tissue Second European Meeting on Pathogenesis and Host Response in Helicobacter pylori infections [Details] | |||||||||
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Associations
| Association: American Society of Microbiology (ASM), Function/Role: member |
| Association: Society for General Microbiology (SGM), Function/Role: Irish Branch Committee Member |
Committees
| Committee : Science Promotion Committee |
Education
| Year 1999 Institution: University College Dublin Qualification: PhD Subject: |
| Year 1995 Institution: Trinity College Dublin Qualification: BA Subject: |
Teaching Interests
| SCI10010 - Scientific Enquiry MICR 20030 - Microbiology in Medicine, Industry and Environment MICR 20040 - The Microbial World BMOL 30030 - Regulation of Gene Expression MICR 40050 - Foodborne Pathogens MICR 40010 - Recombinant DNA Technology BIOC 40120 - MSc Biotech Project |
Recent Postgraduates
Current Postgraduate Students
| Claire Shortt, Doctor of Philosophy (PhD) - Thesis Supervisor |
| Eoin Scanlan, Doctor of Philosophy (PhD) - Thesis Supervisor |
Modules Taught
| 201100 MICR20040 Microbiology: The Microbial World |
| 201000 BIOC40120 Biochemistry: MSc Biotech Project |
| 201000 MICR40010 Microbiology: Recombinant DNA Technology |