Bond Group

Childhood and Adolescent Leukaemia

Group Members

Jonathan Bond
Group Leader
Luke Jones
Postdoctoral Researcher
Peter McCarthy
Clinical Research Fellow
Thomas Lefeivre
Ph.D. Student

About the Group

What we do 

Outcomes for children and adolescents with leukaemia have improved hugely over the past several decades, but there is still much room for improvement. Management of relapse remains challenging, while the side-effects of chemotherapy can sometimes be severe and debilitating, particularly in adolescents. 

Development of better treatments requires improved understanding of the molecular processes that underpin leukaemia biology. The genomic age has seen an explosion in our knowledge of paediatric leukaemia genetics, transcription and epigenetics. The volume and complexity of these data mean that intelligent analysis requires interdisciplinary collaboration between clinicians, biologists and computational and informatic experts. 

We are using systems biology approaches to investigate the mechanisms of oncogenesis and treatment resistance in childhood and adolescent leukaemias. We are particularly interested in how the normal haematopoietic system is perturbed in leukaemia, and how disruptions of epigenetic and transcriptional programs contribute to oncogenesis and treatment resistance. 

Work with us 

Advertisements for PhD and post-doctoral positions will be available on the SBI website and elsewhere. We would also be interested in supporting independent funding applications. For all enquiries and discussion about available opportunities, please contact Jonathan Bond by e-mail. 

Publications: 

Polycomb Repressive Complex 2 haploinsufficiency identifies a high-risk subgroup of pediatric acute myeloid leukemia.  
Bond J, Labis E, Marceau-Renaut A, Duployez N, Labopin M, Hypolite G, Michel G, Ducassou S, Boutroux H, Nelken B, Bertrand Y, Baruchel A, Petit A, Asnafi V, Leverger G, Preudhomme C, Macintyre E, Lapillonne H. 
Leukemia 2018 (In press). 

Novel Intergenically Spliced Chimera, NFATC3-PLA2G15, is associated with aggressive T-ALL biology and outcome. 
Bond J, Tran Quang C, Hypolite G, Belhocine M, Bergon A, Cordonnier G, Ghysdael J, Macintyre E, Boissel N, Spicuglia S, Asnafi V.  
Molecular Cancer Research. 2018 Mar;16(3):470-475. 

Early response-based therapy stratification improves survival in adult ETP-ALL: a GRAALL study. 
Bond J, Graux C, Lhermitte L, Lara D, Cluzeau T, Leguay T, Cieslak A, Trinquand A, Pastoret C, Belhocine M, Spicuglia S, Lheritier V, Leprêtre S, Thomas X, Huguet F, Ifrah N, Dombret H, Macintyre E, Boissel N, Asnafi V.  
Journal of Clinical Oncology 2017 Aug 10;35(23):2683-2691. 

CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis. 
Cordonnier G, Mandoli A, Radhouane A, Hypolite G, LhermitteL, Belhocine M, Asnafi V, Macintyre E, Martens J, Fumagalli S, Bond J.  
Leukemia 2017 Jun;31(6):1443-1446. 

Early Thymic Precursor-like lymphomatous presentation of the ETV6-NCOA2 translocation. 
Bond J, Touzart A, Nadal N, Trinquand A, Thouvenin S, Da Cruz V, Bonté PE, Radford-Weiss I, Garnier N, Stéphan JL, Macintyre E.  
British Journal of Haematology 2018 May;181(3):392-394. Epub 2017 Mar 8. 

Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia. Bond J, Domaschenz R, Roman-Trufero M, Sabbattini P, Ferreiros-Vidal I, Gerrard G, Asnafi V, Macintyre E, Merkenschlager M, Dillon N.  
Oncotarget 2016 Oct 4;7(40):65923-65936. 

An early thymic precursor phenotype predicts outcome exclusively in HOXA-overexpressing adult T-cell Acute Lymphoblastic Leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study. 
Bond J, Marchand T, Touzart A, Cieslak A, Trinquand A, SuttonL, Radford-Weiss I, Lhermitte L, Spicuglia S, Dombret H, Macintyre E, Ifrah N, Hamel JF, Asnafi V.  
Haematologica 2016;101(6):732-40. 

NAP1L1-MLLT10 is a rare recurrent translocation that is associated with HOXA activation and poor treatment response in T-cell acute lymphoblastic leukaemia. 
Bond J, Touzart A, Cieslak A, Trinquand A, Marchand T, Escoffre M, Contet A, Muller M, Schmitt C, Fest T, Asnafi V, Macintyre E. 
British Journal of Haematology 2016;174(3):470-3. 

Cryptic XPO1-MLLT10 translocation is associated with HOXA locus deregulation in T-ALL  
Bond J, Bergon A, Durand A, Tigaud I, Thomas X, Asnafi V, Spicuglia S, Macintyre E.  
Blood 2014;124(19):3023-5. 

News: 

National Children’s Research Centre Crumlin supports a new UCD chair in paediatric haemato-oncology: 

http://www.ucdfoundation.ie/2018/03/29/ncrc-supports-new-chair-paediatric-haemato-oncology/ 

https://www.nationalchildrensresearchcentre.ie/news/new-research-programme-ucd/ 

Irish Examiner article on adolescent blood cancers and the new research program: 

https://www.irishexaminer.com/breakingnews/lifestyle/features/blood-sweat-and-tears-to-survive-cancer-839253.html 

Systems Biology Ireland blog: 

http://www.ucd.ie/sbi/blog/all/blogbodycontent,405834,en.html 

 

 

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