Group Members

Günther Eissner
Group Leader
Simeng Li
Ph.D. Student
Isabel Quiros
Research Assistant
Leila Smith
Ph.D. Student

About the Group

What We Do

The Eissner Group's major research focus is on endothelial and mesenchymal stem cells in transplant medicine and oncology, i.e. the monitoring and preventing endothelial-specific adverse immunological reactions in transplant settings and the development of new tumour-specific anti-angiogenic strategies in cancer. They aim to develop an individualised, risk-adapted approach to endothelial targeted protection in the course of allogeneic transplantation.

 

Among other projects Guenther Eissner’s group is funded by the National Children’s Research Centre (NCRC, grant code A/18/4), a collaborative project together with Professor Owen Smith (Our Lady’s Children’s Hospital, Crumlin, Dublin, and SBI/UCD)

Title of the project: The in-vitro risk stratification of endothelial-specific immune reactions post allogeneic haematopoietic stem cell transplantation

Summary of the project: Bone marrow transplant is the only curative option for certain leukaemias and other hereditary disorders many of which can be fatal in childhood. Endothelial damage plays a role in transplant related complications, such as veno-occlusive disease of the liver and graft versus host disease. Damage to the endothelium ensues from toxicity of the conditioning chemoradiotherapy and alloreactivity of donor lymphocytes, a subset of which are specific to the vasculature. We aim to develop an individualised, risk-adapted approach to endothelial targeted protection in the course of allogeneic transplantation. To this end we will generate a patient-specific endothelial cell source by the differentiation of mesenchymal stem cells.

 

 

 

 

Gunther is also currently acting as Guest Editor for a Special Issue of the journal Cells.

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