Rauch Group

Overcoming Drug Resistance in Melanoma by Personalising Treatment

Group Members

Jens Rauch
Group Leader
Honey Bokharaie
Ph.D. Student
Shannon Lee
Ph.D. Student
Zhi Liu
Ph.D. Student
Ashish Neve
Ph.D. Student
Elisa Panada
Ph.D. Student

About the Group

What we do 

Malignant melanoma is a skin cancer that is one of the deadliest cancers because of its tendency to spread rapidly and its resistance to drugs. The introduction of Raf inhibitors has profoundly changed the therapy of metastatic melanoma. However, despite impressive response rates resistance develops fast and frequently. Resistance is mainly due to network adaptations that bypass the drug blockade. 

Our research focuses on elucidating the underlying mechanisms and the network adaptations of drug resistance in order to design personalized drug combinations that can avoid or overcome this resistance. In addition, we aim to derive diagnostic biomarkers that predict which drug combinations will be most effective for individual patients. 

Recent Publications   

(For a complete list see Google Scholar)  

Rukhlenko OR, Khorsand F, Rozanc J, Alexopoulos L, Rauch N, Hlavacek WS, Posner RG, Gómez-Coca S, Rosta E, Fitzgibbon C, Matallanas D, Rauch J, Kolch W, and Kholodenko BN. Dissecting RAF inhibitor resistance by structure-based dynamic modeling reveals drug combinations to overcome oncogenic RAS signaling to ERK. Cell Systems 

Verlande A, Krafčíková M, Potěšil D, Trantírek L, Zdráhal Z, Elkalaf M, Trnka J, Souček K, Rauch N, Rauch J, Kolch W, Uldrijan S.  Metabolic stress regulates ERK activity by controlling KSR-RAF heterodimerization. EMBO Reports 

Pelosse M, Crocker H, Gorda B, Lemaire P, Rauch J, and Berger I (2017). MultiBac: from protein complex structures to synthetic viral nanosystems. BMC Biol 15, 2581. Review 

Rauch, J., and Kolch, W. Spatial regulation of ARAF controls the MST2-Hippo pathway. (2017). Small Gtpases. Review 

Fey D, Matallanas D, Rauch J, Rukhlenko OS, Kholodenko BN The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells. (2016) Semin Cell Dev Biol. Review  

Baljuls A, Dobrzyński M, Rauch J, Rauch N and Kolch W Stabilization of C-RAF:KSR1 Complex by DiRas3 Reduces Availability of C-RAF for Dimerization with B-RAF Signalling (2016) Cellular Signaling  

Bryan K, Jarboui M, Raso C, Bernal-Llinares M, McCann B, Rauch J, Boldt K and Lynn DJ HiQuant: Rapid Postquantification Analysis of Large-Scale MS-Generated Proteomics Data. (2016) Journal of Proteome Research  

Rauch J, Van Damme D, Mack B, McCann B, Volinsky N, Blanco B, Gires O and Kolch W. Differential Localization of A-Raf Regulates MST2-mediated Apoptosis During Epithelial Differentiation. (2016) Cell Death and Differentiation  

Farrell J, Kelly C, Rauch J, Kida K, García Muñoz A, Monsefi N, Turriziani B, Doherty C, Mehta JP, Matallansa D, Simpson J, Kolch W, and Von Kriegsheim A. HGF induces epithelial-to-mesenchymal transition by modulating the mammalian Hippo/MST2 and ISG15 pathways. (2014) Journal of Proteome Research 

 

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