PhD Student: 'Quantitative analysis of signal transduction network rewiring in colon cancer context.'
Reports to: Dr Christina Kiel
Post duration: 4 years funded
Salary: €18,500 per annum tax-free stipend.
Closing date: November 15, 2017.
Application: Please send a CV and accompanying documentation including references to Dr Christina Kiel. Email address: email@example.com
The PhD student post will be part of an interdisciplinary team working on the quantitative and systems analysis of signaling networks in colon cancer. This study is funded through Science Foundation Ireland (SFI). The project will investigate how signalling and protein interaction networks are context-specific quantitatively modulated in (patho)physiologically-relevant primary cells and in vivo-like 3D model systems. Specifically, we will study how protein interactions control cellular phenotypes by investigating (i) how they generate cell type specific vs. general functions; (ii) how pathogenic mutations affect these interactions and downstream signalling; and (iii) how signal flow changes can be validated by generating mutations that rewire networks in a designed fashion.
The student will gain valuable knowledge in the analysis of signal transduction networks in colon cancer, protein analysis techniques, and standard methods used in molecular and cell biology. The student will also be involved in the computational aspects of the project through interaction with other researchers in the team.'
We are looking for a highly motivated, passionate PhD candidate with the ability to independently plan and conduct the research project while integrating into an interdisciplinary research environment. Applicants should have, or expect to obtain, a first or upper second class honours Bachelors or Masters degree in Biology, Biochemistry, Systems Biology, Chemistry or related fields. Excellent analytical and communication skills are preferable.