Below is our list of Senior Researchers.
My expertise is bioinformatics and statistical, mathematical models. My interests include the analysis of heterogeneous high-throughput omics experiments to infer gene and protein regulatory networks and driver pathways responsible for observed biological phenomena. I use integrative computation approaches that include orthogonal omics data.
Hilary works on the SmartNanoTox project, which focuses determining the toxicity of inhaled nanoparticles and establishing a system for classing new nanoparticles based on their ability to produce the pathway-relevant key event.
My research is focused on investigating the crosstalk between proteins involved in epigenetic regulation of gene expression, and those involved in signalling pathways frequently altered in melanoma. In particular, I am interested in studying how this crosstalk may facilitate acquired drug resistance, and how inhibition of specific epigenetic machinery might abrogate this resistance.
Aleksanders work focuses on the interpretation of genomics data in the childhood malignancy neuroblastoma and on identifying novel signalling vulnerabilities as well as leads for future therapies. He is currently engaged with the melanoma research project and the investigation of resistance mechanisms to Raf targeting chemotherapeutics.
My research focuses on identifying key mediators in inflammatory skin diseases such as Hidradenitis Suppurativa, Atopic dermatitis and Psoriasis using proteomics data generating in in vitro/in vivo models. The results will help identifying optimal therapeutic approaches for these challenging diseases.
My research project is focused on the study of the pathogenesis of childhood cancer, identifying prognostic markers and novel therapeutic targets in MYC/MYCN-driven neuroblastoma by using -omics and systems biology approaches.