Below is our list of SBI students.
Elisa joined SBI in September 2015 having completed a degree in Molecular Biotechnology at the University of Torino. Her current research is focused on the kinase activity of Raf dimers and to their role in resistance to Raf inhibitors.
My research focuses on analysing the effects of genetic mutations on MAPK pathway in melanoma; previously I studied at Nanjing Agriculture University working on molecular biology and genetic engineering.
As part of her research, Stephanie will investigate the role of LATS1 in metastatic melanoma through creation of a dynamic computational model. She will also colloborate with her PI and a Post-doc to investigate how alteration in MTS2/LATS1 signalling network will influence melanoma progression.
We have recently identified (Vallejo, A. et al., Nat Commun, 2017) the transcription factor FOS-like antigen 1 (FOSL 1), as a key component of the signaling program ignited by mutant KRAS. I will be looking at the proteomic analysis and the data integration to generate an interaction network for the prediction of vulnerabilities in KRAS-driven cancers.
Below is our list of former SBI students.
Pathologies like Cancer, & Noonan,Cardiofaciocutaneous & Watson syndromes as well as Neurofibromatosis are due to malfunctions on the MAPK pathway. My work tried to understand the effects of NF1 and ERKs feedback on RAS activation/deactivation.