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Research Programme
• Regulation of follicular growth in cattle;
• Synchronisation of oestrus in cattle;
• Duration of dominance of pre-ovulatory follicle and fertility in
heifers;
• Postpartum reproduction in cows.
Publications 1996-2006
Roche JF. (1996). Control and regulation of folliculogenesis - a symposium in perspective. Rev. Reprod., 1:19-27.
Sunderland SJ, Knight PG, Boland MP, Roche JF and Ireland JJ. (1996). Alterations in intrafollicular levels of different molecular mass forms of inhibin during development of follcular- and luteal-phase dominant follicles in heifers. Biol. Reprod., 54:453-462.
Finnerty M, Enright WJ, Prendiville DJ, Spicer LJ and Roche JF. (1996). The effect of different levels of gonadotrophin-releasing hormone antibody titres on plasma hormone concentrations, sexual and aggressive behaviour, testis size and performance of bulls. Anim. Sci., 63:51-63.
Cooke DJ, Crowe MA, Roche JF and Headon DR. 1996. Review - Gonadotrophin heterogeneity and its role in farm animal reproduction. Anim. Reprod. Sci., 41:77-99.
Carroll CM, Lynch PB, Boland MP, Spicer LJ, Austin FH, Leonard N, Enright WJ and Roche JF. (1996). The effects of food intake during lactation and post weaning on the reproductive performance and hormone and metabolite concentrations of primiparous sows. Anim. Sci., 63:297-306.
Goulding D, Williams DH, Roche JF and Boland MP. (1996). Factors affecting superovulation in heifers treated with PMSG. Theriogenology, 45:765-773.
Crowe MA, Roche JF and Enright WJ. (1996). Administration of prostaglandin F2a to heifers with persistent corpora lutea following prostaglandin F2a immunization: oestrus and ovarian responses. Anim. Reprod. Sci., 44:71-78.
Ireland JJ, Good TEM, Ireland JLH, Knight PG, de la Sota RL, Thatcher WW, Mihm M, and Roche JF. (1996). Alterations in inhibins and activins during turnover of the first-wave dominant non-ovulatory follicle in cattle. J. Reprod. Develop., 42:41-45.
Crowe MA, Roche JF and Enright WJ. (1996). Administration of prostaglandin F2a ?to heifers with persistent corpora lutea following prostaglandin F2a immunization: oestrus and ovarian responses. Anim. Reprod. Sci., 44:71-78.
Sweeney T, Donovan A, Roche JF and O'Callaghan D. (1997). Variation in the ability of a long day followed by a short day photoperiod signal to initiate reproductive activity in ewes at different times of the year. J. Reprod. Fertil., 109:121-127.
Sweeney T, Donovan A, Karsch FJ, Roche JF and O'Callaghan D. (1997). Influence of previous photoperiodic exposure on the reproductive response to a specific photoperiod signal in ewes. Biol. Reprod., 56:916-920.
Cooke DJ, Crowe MA and Roche JF. (1997). Circulating FSH isoform patterns during recurrent increases in FSH throughout the oestrous cycle of heifers. J. Reprod. Fertil., 110:339-345.
Mihm M, Good TEM, Ireland JLH, Ireland JJ, Knight PG and Roche JF. (1997). Decline in serum follicle-stimulating hormone concentrations alters key intrafollicular growth factors involved in selection of the dominant follicle in heifers. Biol. Reprod., 57:1328-1337.
Papaioannou KZ, Murphy RP, Monks RS, Hynes N, Ryan MP, Boland MP and Roche JF. (1997). Assessment of viability and mitochondrial function of equine spermatozoa using double staining and flow cytometry. Theriogenology, 48:299-312.
Kelly P, Duffy P, Roche JF, and Boland MP. (1997). Superovulation in cattle: effect of FSH type and method of administration on follicular growth, ovulatory response and endocrine patterns. Anim. Reprod. Sci., 46:1-14.
Baguisi A, Arav AT, Crosb, F, Roche JF and Boland MP. (1997). Hypothermic storage of sheep embryos with antifreeze proteins: Development in vitro and in vivo. Theriogenology, 48:1017-1024.
Mantovani R, Enright WJ, Roche JF and Boland MP. (1997). The effect of immunization of heifers against a 1-26 inhibin conjugate on the superovulatory response to pFSH. Theriogenology, 47:511-519.
Crowe MA, Padmanabhan V, Hynes N, Sunderland SJ, Enright WJ, Beitins IZ and Roche JF. (1997). Validation of a sensitive radioimmunoassay to measure serum follicle-stimulating hormone in cattle: correlation with biological activity. Anim. Reprod. Sci., 48:123-136.
Finnerty M, Enright WJ and Roche JF. (1998). Testosterone, LH and FSH episodic secretory patterns in GnRH-immunized bulls. J. Reprod. Fertil., 114:85-94.
Murphy MG, Boland MP and Roche JF. (1998). The effects of dose and duration of administration of pFSH during the first follicular wave on the ovulation rate of beef heifers. Theriogenology, 49:557-569.
Roche JF, Austin E, Ryan M, O'Rourke M, Mihm M and Diskin M. (1998). Hormonal regulation of the oestrous cycle of cattle. Reprod Dom Anim., 33:227-231.
Crowe MA, Padmanabhan V, Mihm M, Beitins IZ. and Roche JF. (1998). Resumption of follicular waves in beef cows is not associated with periparturient changes in follicle-stimulating hormone heterogeneity despite major changes in steroid and luteinizing hormone concentrations. Biol. Reprod., 58:1445-1450.
Stagg K, Spicer LJ, Sreenan JM, Roche JF and Diskin MG. (1998). Effect of calf isolation on follicular wave dynamics, gonadotropin and metabolic hormone changes, and interval to first ovulation in beef cows fed either of two energy levels postpartum. Biol. Reprod. 59:777-783.
Roche JF, Mihm M, Diskin MG and Ireland JJ. (1998). A review of regulation of follicle growth in cattle. J. Anim. Sci., 76:16-29.
Roche JF. (1999). Reproductive efficiency in postpartum cows. Italian Association for Buiatrics, Vol. XXXI, Marina di Ragusa, 18-20 June 1999.
Austin EJ, Mihm M, Ryan MP, Williams DH and Roche, JF. (1999). Effect of duration of dominance of the ovulatory follicle on onset of estrus and fertility in heifers. J. Anim. Sci., 77:2219-2226.
Mihm M, Curran N, Hyttel P, Knight PG, Boland MP and Roche JF. (1999). Effect of dominant follicle persistence on follicular fluid oestradiol and inhibin and on oocyte maturation in heifers. J. Reprod. Fertil. 116:293-304.
Mackey DR, Sreenan JM, Roche JF and Diskin MG. (1999). The effect of acute nutritional restriction on incidence of anovulation and periovulatory estradiol and gonadotropin concentrations in beef heifers. Biol. Reprod., 61:1601-1607.
Roche JF, Austin EJ, Ryan M, O’Rourke M, Mihm M and Diskin MG. (1999). Regulation of follicle waves to maximize fertility in cattle. J. Reprod. Fertil. Suppl., 54:61-71.
Mackey DR, Wylie ARG, Sreenan JM, Roche JF and Diskin M. (2000). The effect of acute nutritional change on follicle wave turnover, gonadotropin and steroid concentration in beef heifers. J. Anim. Sci., 78:429-442.
Duffy P, Crowe MA, Boland MP and Roche JF. (2000). The effect of exogenous LH pulses on the fate of the first dominant follicle in postpartum beef suckler cows. J. Reprod. Fertil., 118:9-17.
Mackey DR, Sreenan JM, Roche JF, and Diskin MG. (2000). The effect of progesterone alone or in combination with estradiol on follicular dynamics, gonadotropin profiles, and estrus in beef cows following calf isolation and restricted suckling. J. Anim. Sci., 78:1917-1929.
Roche JF, Mackey D and Diskin MG. (2000). Reproductive management of postpartum cows. Anim. Reprod. Sci., 60-61:703-712.
O'Rourke M, Diskin MG, Sreenan JM and Roche JF. (2000). The effect of dose and route of oestradiol benzoate administration on plasma concentrations of oestradiol and FSH in long-term ovariectomised heifers. Anim. Reprod. Sci., 59:1-12.
O'Doherty E, Aherne M, Ennis S, Weavers E, Hunter N, Roche JF and Sweeney T. (2000). Detection of polymorphisms in the prion protein gene in a population of Irish Suffolk sheep. Vet. Rec., 146:335-338.
Sweeney T, Nicol L, Roche JF and Brooks AN. (2000). Maternal exposure to octylphenol suppresses ovine fetal follicule-stimulating hormone secretion, testis size, and sertoli cell number. Endocrinology, 141(7):2667-2673.
Mihm M, Austin EJ, Good TEM, Ireland JLH, Knight PG, Roche JF and Ireland JJ. (2000). Identification of potential intrafollicular factors involved in selection of dominant follicles in heifers. Biol. Reprod., 63:811-819.
Roche JF and Diskin MG. (2000). Resumption of reproductive activity in the early postpartum period of cows. Italian Association for Buiatrics, Vol. XXXII, Stresa (VB) 5-7 May 2000.
Lane EA, Austin EJ, Crowe MA and Roche JF. (2001). The effect of oestradiol benzoate (ODB) or a synthetic gonadotrophin releasing hormone (GnRH) used at the start of a progesterone treatment on onset and synchrony of oestrus in cattle. British Soc. Anim. Sci., 26:475-478.
Crowe MA, Enright WJ, Boland MP and Roche JF. (2001). Follicular growth and serum follicle-stimulating hormone (FSH) responses to recombinant bovine FSH in GnRH-immunized anoestrous heifers. Anim. Sci., 73:115-122.
O'Doherty E, Aherne M, Ennis S, Weavers E, Roche JF and Sweeney T. (2001). Prion protein gene polymorphisms in pedigree sheep in Ireland. Res. Vet. Sci., 70:51-56.
Crowe MA, Kelly P, Driancourt MA, Boland MP and Roche JF. (2001). Effects of follicle-stimulating hormone with and without luteinizing hormone on serum hormone concentrations, follicle growth, and intrafollicular estradiol and aromatase activity in gonadotropin-releasing hormone-immunized heifers. Biol. Reprod., 64:368-374.
Austin EJ, Mihm M, Evans ACO, Knight PG, Ireland JLH, Ireland JJ and Roche JF. (2001). Alterations in intrafollicular regulatory factors and apoptosis during selection of follicles in the first follicular wave of the bovine estrous cycle. Biol. Reprod., 64:839-848.
Lane EA, Austin EJ, Roche JF and Crowe MA. (2001). The effect of estradiol benzoate on synchrony of estrus and fertility in cattle after removal of a progesterone-releasing intravaginal device. Theriogenology, 55:1807-1818.
Lane EA, Austin EJ, Roche JF, Crowe MA. (2001). The effect of estradiol benzoate or a synthetic gonadotrophin-releasing hormone used at the start of a progesterone treatment on estrous response in cattle. Theriogenology, 56:79-90.
Sinclair KD, Molle G, Revilla R, Roche JF, Quintans G, Marongiu L, Sanz A, Mackey DR and Diskin MG. (2002). Ovulation of the first dominant follicle arising after day 21 postpartum in suckling beef cows. Anim. Sci., 75:115-126.
Wright C, Evans ACO, Evans NP, Duffy P, Fox J, Boland MP, Roche JF and Sweeney T. (2002). Effect of maternal exposure to the environmental estrogen, octylphenol, during fetal and/or postnatal life on onset of puberty, endocrine status, and ovarian follicular dynamics in ewe lambs. Biol. Reprod., 67:1734-1740.
O’Doherty E, Healy A, Aherne M, Hanrahan JP, Weavers E, Doherty M, Roche JF, Gunn M and Sweeney T. (2002). Prion protein (PrP) gene polymorphisms associated with natural scrapie cases and their flock-mates in Ireland. Research in Vet. Sci. 73:243-250.
McElroy MC, Parada MG, Church A, Monks E, Weavers E, Breslin P, Healy AM, Doherty ML, Collins JD, O’Doherty E, Roche JF and Sweeney T. (2002). The establishment of a tissue bank of naturally-occurring ovine scrapie cases in the Republic of Ireland. Irish Vet. J. 55:31-34.
Thuring CMA, Crowe MA, McAllister H, Earley B, Roche JF and Sweeney T. (2002). Evaluation of peripheral lymphoreticular biopsy techniques and their clinical side effects in sheep. Vet. Record 150:97-102.
Diskin MG, Austin EJ and Roche JF. (2002). Exogenous hormonal manipulation of ovarian activity in cattle. Dom. Anim. Endocrinology 23:211-228.
Austin EJ, Mihm M, Evans ACO, Ireland JLH, Ireland JJ and Roche JF. (2002). Effects of oestradiol and progesterone on secretion of gonadotrophins and health of first wave follicles during the oestrous cycle of beef heifers. Reprod. 124:531-541.
Evans ACO, O’Keeffe P, Mihm M, Roche JF, Macmillan KL and Boland MP. (2003). Effect of oestradiol benzoate given after prostaglandin at two stages of follicle wave development on oestrus synchronisation, the LH surge and ovulation in heifers. Anim. Reprod. Sci. 76:13-23.
Diskin MG, Mackey DR, Roche JF and Sreenan JM. (2003). Effects of nutrition and metabolic status on circulating hormones and ovarian follicle development in cattle. Anim. Reprod. Sci. 78:345-370.
Duffy P, Crowe MA, Austin EJ, Mihm M, Boland MP and Roche JF. (2004). The effect of eCG or estradiol at or after norgestomet removal on follicular dynamics, estrus and ovulation in early post-partum beef cows nursing calves. Theriogenology 61:725-734.
Lane EA, Padmanabhan V, Roche JF, Crowe MA. (2005) Alterations in the ability of the bovine pituitary gland to secrete gonadotropins in vitro during the first follicle-stimulating hormone increase of the estrous cycle and in response to exogenous steroids. Domest Anim Endocrinol. 28:190-201
Keane CJ, Hanlon, AJ, Roche, JF, Burton, JL, Mee, J.F, O’Doherty, JV,
Sweeney, T. 2006. A potential antiapoptotic phenotype in neutrophils of
cows milked once daily in early lactation. J. Dairy Sci., 89:1024-7
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