UCD Department of Medicine & Therapeutics
Mater Misericordiae Hospital, Eccles Street, Dublin 7, Ireland
Telephone: +353-1-830 7419   Fax: +353-1-830 8404

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UCD

Recent Publications

1. Professor Hugh R. Brady

Stromski ME, Brady HR, Gullans SR, Patz S. Imaging of regional renal perfusion using missing pulse steady state free precession. Magn Res Med 1991; 20: 66-77.

Mulkern RV, Stromski ME, Brady HR, Gullans SR, Jolesz FA. Regional measurement of 1H NMR transverse magnetization decay curves in perfused kidney: A potential method for measuring water compartmentation and exchange rates with MRI. Magn Res Med 1991; 20: 78-85.

Lynch T, Kinirons MT, O’Callaghan D, Ismail S, Brady HR, Horgan JH. Metabolic changes during serial squash matches in older men. Can J Spt Sci 1992; 17: 110-113.

Denton MD, Marsden PA, Luscinskas FW, Brenner BM, Brady HR. Cytokine-induced phagocyte adhesion to human mesangial cells: role of CD11/CD18 integrins and ICAM-1. Am J Physiol 1991; 261: F1071-F1079.

Zeidel ML, Brady HR, Kohan DE. Interleukin-1 inhibition of Na+K+-ATPase in inner medullary collecting duct cells: role of PGE2. Am J Physiol 1991; 261: F1013-F1016.

Gunning ME, Brady HR, Otuechere G, Brenner BM, Zeidel ML. Atrial natruiretic peptide (31-67) inhibits Na+ transport in inner medullary collecting duct cells. J Clin Invest 1992; 89: 1411-1417.

Brady HR, Denton MD, Jimenez W, Takata S, Palliser D, Brenner BM. Chemoattractants provoke monocyte adhesion to human mesangial cells and mesangial cell injury via CD11/CD18-ICAM-1 dependent and independent mechanisms. Kidney Int 1992; 42: 480-487.

Brady HR, Serhan CN. Adhesion promotes transcellular leukotriene biosynthesis during neutrophil-glomerular endothelial cell interactions: inhibition by anti-CD18 and L-selectin monoclonal antibodies. Biochem Biophys Res Commun 1992; 186: 1307-1314.

Brady HR, Spertini O, Jimenez W, Brenner BM, Marsden PA, Tedder TF. Neutrophils, monocytes, and lymphocytes bind to cytokine-activated glomerular endothelial cells through L-selectin (LAM-1). J Immunol 1992; 149: 2437-44.

Brady HR, Serhan CN. Neutrophil adhesion to glomerular mesangial cells: regulation by eicosanoids. Adv Exper Med Biol 1992; 314: 347-360.

Kelly CP, O’Keane JC, Orellana J, Schroy PC, Yang S, LaMont JT, Brady HR. Human colon cancer cells express ICAM-1 in vivo and support LFA-1-dependent lymphocyte adhesion in vitro. Am J Physiol 1993; 263: G864-G870.

Brady HR, Zeidel ML, Kone BC, Gullans SR. Differential actions of cisplatin on renal proximal tubule and inner medullary collecting duct cells. J Pharm Exper Therapeut 1993; 265: 1421-1428.

Takata S, Matsubara M, Allen PG, Janmey PA, Serhan CN, Brady HR. Remodelling of neutrophil phospholipids with 15(S)-hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endothelium. J Clin Invest 1994; 93: 499-508.

Takata S. Papayianni A, Matsubara M, Pronovost P, Jimenez J, Brady HR. 15(S)-hydroxyeicosatetraenoic acid inhibits trafficking of human neutrophils across cytokine-activated endothelium. Am J Pathol 1994; 145: 541-549.

Chertow G, Brady HR. Hyponatremia from tap-water enemas (letter). Lancet 1994; 344: 748.

Brady HR, Lamas S, Takata S, Jimenez W, Matsubara M, Marsden PA. Lipoxygenase product formation and cell adhesion during interactions of human neutrophils and glomerular endothelial cells. Am J Physiol 1995; 37: F1-F12.

Kelly CP, Keates S, Siegenberg D, Linevsky JK, Pothoulakis C, Brady HR. IL-8 secretion and neutrophil activation by HT29 colonic epithelial cells. Am J Physiol 1994; 267: G991-G997.

Papayianni A, Rennke H, Serhan CN, Brady HR. Platelet-leukocyte adhesion through P-selectin facilitates transcellular lipoxin biosynthesis in experimental acute glomerulonephritis. Kidney Int 1995; 47: 1295-1302.

Colgan CP, Parkos CA, McGuirk D, Brady HR, Papayianni AA, Madara JL. Receptors involved in carbohydrate binding modulate intestinal epithelial-neutrophil interactions. J Biol Chem 1995; 270: 10531-10539.

Serhan CN, Maddox JF, Brady HR, Colgan SP, Madara JL. Design of lipoxin A4 stable analogues that block transmigration and adhesion of human neutrophils. Biochem J 1995; 34: 14609-14615.

Papayianni A, Serhan CN, Brady HR. Lipoxins inhibit leukotriene-induced adhesion of human leukocytes and endothelial cells supported by ß2 integrins and P-selectin. J Immunol 1996; 156: 2264-2272.

Pronovost P, Gunning M, Espinosa O, Rennke HG, Brady HR. Clinico-pathologic correlations, predictors of disease progression and outcome of renal transplantation in fibrillary and immunotactoid glomerulopathy. Nephrol Dial Transplant 1996; 11: 1-6.

Mayadas T, Mendrick D, Papayianni A, Brady HR, Cotran RS. Impaired lipoxin generation and exaggerated neutrophil recruitment during glomerulonephritis in P-selectin deficiency. Kidney Int 1996; 49: 1342-1349.

Brady HR. Leukocyte adhesion molecules: novel targets for therapeutic intervention in acute glomerulonephritis. Curr Op Nephrol Hyperten 1993; 2: 171-182.

Brady HR, Papayianni A, Serhan CN. Leukocyte adhesion promotes biosynthesis of lipoxygenase products by transcellular routes. Kidney Int 1994; 45: S90-97.

Brady HR. Leukocyte adhesion molecules and kidney diseases. Kidney Int 1994; 45: 1285-1300.

Brady HR. The endothelium in glomerular inflammation. Curr Opin Nephrol Hyperten 1995; 4: 277-286.

Brady HR, Serhan CN. Potential vascular roles for lipoxins in the “stop programs” of host defense and inflammation. Trends Cardiovasc Med 1995; 5: 186-192.

Brady HR. Acute Renal Failure. Lancet 1995; 346: 1533-1540.

Brady HR, Serhan CN. Lipoxins: Endogenous inhibitors of neutrophil recruitment during inflammation. Curr Opin Nephrol Hyperten 1996; 5: 20-27.

Madore F, Lazarus JM, Brady HR. Therapeutic plasma exchange and kidney diseases. J. Am. Soc. Nephrol. 7: 367-386, 1996.

Denton MD, Chertow G, Brady HR. “Renal-dose” dopamine for the treatment of acute renal failure: A review of the scientific rationale, experimental studies and clinical trials. Kidney Int 1996; 49: 4-14.

O’Meara YM, Brady HR. Lipoxins, leukocyte recruitment and the resolution phase of acute glomerulonephritis. Kidney Int 1997 (in press).

Brady HR, Brenner BM. Acute Renal Failure. In: Harrison’s Principles of Internal Medicine. Isselbacher et al. Eds, 13th Ed. McGraw Hill 1994, 1264-70.

Brady HR, and Serhan CN. Lipid Mediators of Inflammation. In: Basic and Clinical Immunology: Basic Mechanisms and Clinical Consequences. Eds: LH Siegel and Y Ron, McGraw Hill, New York, 1994, 271-286.

Brady HR. Leukocyte Adhesion Molecules and Diseases of the Kidney. In: Molecular Nephrology: Kidney Function in Health and Disease. Eds: D Schlondorff and J Bonventre. 1st Ed, Marcel Dekker, Inc., New York, 717-740.

Brady HR, Adler S. Cell-cell and Cell-Matrix Interactions. In: The Kidney. Eds: Brenner BM & Rector FC. 5th Ed, WB Saunders, Philadelphia 1996: 193-210.

Brady HR, Brenner BM, Lieberthal W. Acute Renal Failure. In: The Kidney. Eds: Brenner BM & Rector FC. 5th Ed, WB Saunders, Philadelphia 1996: 1200-1252.

2. Professor David Powell

O’Shea D., Powell D. Growth Hormone Therapy in Turner’s Syndrome. IMJ June 1992 Vol 85: No 2 68-69.

Brennan D.P., Powell D. The Mechanism of the Parathyroid Hormone - Receptor interaction : Characterisation of the Ligand Binding Site of the Parathyroid Hormone Receptor. Journal of Endocrinoligical Investigation 14 (5) 42. 1991.

Brennan D., Powell D. The parathyroid hormone receptor: the contribution of disulphides to function. British Journal of Endocrinology 129: 135. 1991.

Powell D. Effect of growth hormone on bone collagen synthesis (a review). International Growth Monitor. Vol 1 No 5 Pg. 11-12 1991.

Powell D. Effect of growth hormone treatment on endogenous adrenal androgen secretion. International Growth Monitor, Vol 2. No.2. Pg 58 (1992).

Brennan D.P., Powell D. Structure/function naalyses of a parathyroid hormone receptor. Submitted to the European Journal of Biochemistry, (1992).

Bourke W., Powell D. Hypoglycaemia due to adult nesidioblastosis. A diagnostic and therapeutic problem. Journal Int. Med. (submitted 1992).

3. Dr. Yvonne M. O’Meara

Green A, O’Meara YM, Campbell E, Carmody M, Donohoe J. Successful Treatment with Cyclosporin of Nephrotic Syndrome due to Focal Segmental Glomerulosclerosis Recurring in a Renal Transplant. Nephrol Dial Transplant 58: 309-314, 1991

Natori Y, O’Meara YM, Manning ECM, Minto AW, Levine JS, Weise WJ, Salant DJ. Production and Polarized Secretion of Basement Membrane Components by Cultured Glomerular Epithelial Cells. Am J Physiol 262 (Renal Fluid Electrolyte Physiol) 31:F131-F137, 1992.

O’Meara YM, Natori Y, Minto AWM, Goldstein DJ, Manning EC, Salant DJ. Nephrotoxic Antiserum Identifies a ß1 Integrin on Rat Glomerular Epithelial Cells. Am J Physiol 262:(Renal Fluid Electrolyte Physiol.)31:F1083-1091, 1992.

Weise WJ, Natori Y, Levine JS, O’Meara YM, Minto AW, Manning ECM, Goldstein DG, Abrahamson DR, Salant DJ. Fish Oil has Protective and Therapeutic Effects on Proteinuria in Passive Heymann Nephritis. Kidney Int. 43:359-368, 1993.

Minto AWM, Fogel M, Natori Y, O’Meara YM, Abrahamson DR, Smith B, Salant DJ. Expression of Type 1 Collagen mRNA in Glomeruli of Rats with Passive Heymann Nephritis. Kidney Int 43:121-127, 1993.

Gourlay WA, Yucel EK, Hakaim AG, O’Meara YM, Mesler DE, Kerr K, Cho Sl. Magnetic Resonance Angiography in the Evaluation of Live Renal Donors. Transplantation 60:1363-1366, 1995.

4. Dr. Catherine Godson

Godson, C. and Reppert, S.M. (1997) The Melatonin la receptor is coupled to activation of parallel signal transduction pathways. Endocrinol. 138:397-404.

Godson, C. Masliah, E. Ellisman, M.H. and Insel, P.A. (1996) Isoform specific redistribution of PKC in living cells. Biochim. Biophys. Acta. 1313:63-71.

Roca, A. Godson, C. Weaver, D.R. and Reppert, S.M. (1996) Structure, characterization and expression of gene encoding the mouse Mel la Melatonin receptor. Endocrinology 137:3469-3477.

Reppert, S.M. Weaver, D.R. and Godson C. (1996) Melatonin Receptors step into the light: Cloning and classification of subtypes. Trends in Pharmacol. Sci. 17:101-102.1.

Reppert, S. Weaver, D.R. Cassone, V.M. Godson, C. and Kolakowski, L.F. (1995) Melatonin receptors are for the Birds: Molecular Analysis of two receptor subtypes differentially expressed in chick brain. Neuron 15:1003-1015.

Reppert, S.M. Godson, C. Mahle, C.M. Weaver, D.R. Slaugenhaupt, S.A. and Gusella, J.F. (1995) Molecular characterization of a novel melatonin receptor expressed in human retina and brain: the Mel Ib receptor. Proc. Natl. Acad. Sci. USA. 92:8734-8738.

Balboa, M.A. Firestein, B.L. Godson, C. Bell, K.S., and Insel, P.A. (1994) PKC a mediates phospholipase D activation by ATP, UTP and 2-methylthioATP in MDCK cells independent from phospholipase C activation and arachidonate release. J.Biol. Chem. 269:10511-10516.

Senlin, L. Godson, C. Roche, E. Prentki, M. and Schlegel, W. (1994) Induction of c-fos in pituitary cells by PMA and TRH depends on calcium influx. J. Mol. Endocrinol. 13:303-314.

Godson, C. Bell, K.S. and Insel, P.A. (1993) Inhibition of expression of PKC a by antisense cDNA inhibits phorbol ester mediated arachidonic acid release. J.Biol.Chem. 268:11946-11950.

Masliah, E. Mallory, M. Ge, N. Godson, C. and Saitoh, T. (1993) Phorbol-ester induced neuritic alterations in the rat neocortex. Molec. Chem. Neuropathol. 20:125-145.

Insel, P.A. Weiss, B.A. Howard, M.J. Slivka, S.R. Waite, J.J. and Godson,C. (1991) Regulation of phospholipase activation in MDCK cells. Biochem. Soc. Transact. 19:329-333.

5. Dr. Paola Maderna

Franceschini G, Calabresi L, Maderna P, Galli G, Gianfranceschi G, Sirtori CR. w-3 fatty acids selectively raise high-density lipoprotein 2 levels in healthy volunteers. Metabolism 1991; 40: 1283-1286.

Mussoni L, Mannucci L, Sirtori M, Camera M, Maderna P, Sironi L, Tremole E. Hypertriglyceridemia and regulation of fibrinolytic activity. Arteriosclerosis and Thrombosis 1992; 12: 19-27.

Pazzucconi F, Mannucci L, Mussoni L, Gianfranceschi G, Maderna P, Franceschini G, Sirtori CR, Tremoli E. Bezafibrate lowers plasma lipids, fibrinogen and platelet aggregability in hypertriglyceridemic patients. Eur J Clin Pharmacol 1992; 43: 219-223.

Sirtori CR, Gatti E, Tremoli E, Galli C, Gianfranceschi G, Franceschini G, Colli S, Maderna P, Marangoni F, Perego P, Stragliotto E. Olive, corn oil and n-3 fatty acids differently affect lipids/lipoproteins, platelets and superoxide formation in type II hypercholesterolemia. Am J Clin Nutr 1992; 56: 113-122.

Sirtori CR, Franceschini G, Gianfranceschi G, Vaccarino V, Chiesa G, Maderna P, Bertoli M, Calabresi L. Activity profile of gemfibriozil on the major plasma lipoproteins parameters. Eur J Epidemiol 1992; 8: 120-124.

Tremoli E, Camera M, Maderna P, Sironi L, Prati L, Colli S, Piovella F, Bernini F, Corsini A, Mussoni L. Increased synthesis of plasminogen activator inhibitor-1 by cultured human endothelial cells exposed to native and modified low density lipoproteins. An LDL receptor-dependent phenomenon. Arteriosclerosis and Thrombosis 1993; 13: 338-346.

Maderna P, Colli S, Caruso D, Eligini S, Toia A, Galli G, Tremole E. Quantitative changes of hydroxy acid formation during platelet-neutrophil interaction. J Lab Clin Med 1993; 121: 406-414.

Tremole E, Eligine S, Colli S, Maderna P, Rise P, Pazzucconi F, Marangoni F, Sirtori CR, Galli C. n-3 fatty acid ethyl ester administration to healthy subjects an dto hypertriglyceridemic patients reduces tissue factor by adherent monocytes. Arteriosclerosis and Thrombosis 1994; 14: 1600-1608.

Tremoli E, Eligine S, Colli S, Maderna P, Marangoni F, Angeli MT, Sirtori CR, Galli C. In: Galli C, Simopoulos AP, Tremole E, ed. Effects of w3 fatty acid esters on monocyte tissue factor expression. Dietetics Vol. 76: Fatty Acids and lipids from cell biology to human disease. Basel : S. Karger AG, 1994; 55-59.

Tremoli E, Maderna P, Marangoni F, Colli S, Eligine S, Catalano I, Angeli MT, Pazzucconi f, Gianfranceschi G, Davi G, Stragliotto E, Sirtori Cr, Galli C. Prolonged inhibition of platelet aggregation following n-3 fatty acid ethyl ester administration to healthy volunteers. Am J Clin Nutr 1995; 61: 607-613.

6. Dr. Fiona McPhillips

J Grzybowski, F. McPhillips and T. Brown (1995). The use of 5’-chemically labeled primers in PCR> “PCR: essential data” Wiley ed. C.R. Newton. Chapter 10 pp 93-98.

7. Dr. Cathriona King

Barnett YA, King CM. (1995) An investigation of antioxidant status, DNA repair capacities and mutation as a function of age in humans. Mutation Research 338: 115-128.

King CM, Barnett (1995). Oxidative stress and human ageing. Biochemical Society Transactions 23: 375S.

King CM, Gillespie ES, McKenna PG, Barnett YA. (1994). An investigation of mutation as a function of age in humans, Mutation Research 316: 79-90.

King CM, Wilkinson YA, McKenna PG. Oxidant-induced biomolecule damage and the ageing process. Irish Journal of Medical Science (1994) 163(2), 107.


Forthcoming Publications

Goligorsky M, Brady HR. Cell Adhesion Molecules in Renal Injury. In: Comprehensive Toxicology. Eds: Sipes IG, McQueen CA, Gandolfi AJ. Pergamon 1996 (in press).

Hebert M-J, Brady HR. Leukocyte Adhesion and Renal Inflammation. In: The Immunology of Kidney Disease. Ed: Nielson E and Couser W. 1st Ed. WB Saunders, Philadelphia 1996 (in press).

Brady HR, Brenner BM. Acute Renal Failure. In: Harrison’s Principles of Internal Medicine. Isselbacher et al. Eds: 14th Ed. McGraw Hill 1996 (in press).

Brady HR, Brenner BM. Pathogenic Mechanisms of Renal Injury. In: Harrison’s Principles of Internal Medicine. Isselbacher et al. Eds: 14th Ed. McGraw Hill 1996 (in press).

Brady HR, O’Meara YM, Brenner BM. The Major Glomerulopathies. In: Harrison’s Principles of Internal Medicine. Isselbacher et al. Eds: 14th Ed, McGraw Hill 1996 (in press).

O’Meara YM, Brenner BM, Brady HR. Glomerulopathies Associated with Multisystem Diseases. In: Harrison’s Principles of Internal Medicine. Isselbacher et al. Eds: 14th Ed. McGraw Hill 1996. (in press).

Hebert M-J, Takano T, Brady HR. Sequential morphologic events during apoptosis of human neutrophils: modulation by lipoxygenase-derived eicosanoids. J Immunol (in press).

Obrador GT, Price B, O’Meara YM, Salant DJ. Acute Renal Failure due to Lymphomatous Infiltration of the Kidneys. Am J Kidney Dis 1997 (in press)

O’Meara YM, Galvanek E, Rennke HG, Brady HR. De Novo and Recurrent Collapsing Glomerulopathy after Renal Transplantation. (In review).

King CM, Bristor-Craig HE, Gillespie ES, Barnett YA. A report in vivo antioxidant status, DNA damage, mutation and DNA repair capacity in cultured lymphocytes from 75-80 year old humans. Mutation Research (in press)

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