The Tobin Lab

Group Members

Desmond Tobin
Desmond Tobin
Institute Director, Principal Investigator
Cristina Casalou
Cristina Casalou
Senior Research Scientist
Daniel Johnston
Daniel Johnston
Newman Fellow
Hugo Moreiras
Hugo Moreiras
Newman Fellow
Shahnawaz Jadeja
Shahnawaz Jadeja
Postdoctoral Researcher
Bakht Nasir
Bakht Nasir
Research Assistant
Jay Mayatra
Jay Mayatra
Research Assistant
Irene-Castellano Pellicena
Irene-Castellano Pellicena
SFI Fellow
Dimitra Khalil-Chaity
Dimitra Khalil-Chaity
PhD Student
Sarah Lussoso
Sarah Lussoso
PhD Student

About The Tobin Lab

Keywords: Skin/hair pigmentation in health & disease, Hair growth regulation in health & disease, Immune-mediated skin/hair disorders, Wound-healing, Skin aging.

Using in vitro and ex vivo assays, our lab examines the cellular and molecular control of key skin and hair follicle biologic process in health (incl. aging) and disease. Specific disorders of interest include: melanoma, vitiligo, canities, alopecia areata, psoriasis, vitiligo & diabetic wound healing. We also develop new technologies in skin care.

Join our team

If you would like to find out more about our research,  are interested in collaborating on a project,  or if you would like to discuss  postdoc, PhD or internship opportunities, please contact  desmond.tobin@ucd.ie



Active Research Projects

Current Projects

Past Projects

Recent Publications

 

  1. Castellano-Pellicena I, Morrison CG, Bell M, O'Connor C, Tobin DJ. Melanin Distribution in Human Skin: Influence of Cytoskeletal, Polarity, and Centrosome-Related Machinery of Stratum basale Keratinocytes. Int J Mol Sci. 2021 Mar 19;22(6):3143.DOI: 10.3390/ijms22063143. 
  2. Wall D, Meah N, York K...Tobin DJ,...Zlotogorski A, Zhou C, Sinclair R. A Global eDelphi Exercise to Identify Core Domains and Domain Items for the Development of a Global Registry of Alopecia Areata Disease Severity and Treatment Safety (GRASS). JAMA Dermatol. 2021 Mar 3. DOI: 10.1001/jamadermatol.2020.5839. Epub ahead of print. 
  3. Al-Rikabi AHA, Tobin DJ, Riches-Suman K, Thornton MJ. Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses. Sci Rep. 2021 Jan 14;11(1):1474. DOI: 10.1038/s41598-020-80072-z. 
  4. Bollard SM, Casalou C, Goh CY, Tobin DJ, Kelly P, McCann A, Potter SM. Circulating Melanoma-Derived Extracellular Vesicles: Impact on Melanoma Diagnosis, Progression Monitoring, and Treatment Response. Pharmaceuticals (Basel). 2020 Dec 18;13(12):475. DOI: 10.3390/ph13120475. 
  5. Tobin DJ. Unpicking the Gordian knot of identifying metastasis development-relevant proteins in cutaneous squamous cell carcinoma. Br J Dermatol. 2021 Apr;184(4):593. DOI: 10.1111/bjd.19697. Epub 2020 Dec 16. 
  6. Stress-sensing in the human greying hair follicle: Ataxia Telangiectasia Mutated (ATM) depletion in hair bulb melanocytes in canities-prone scal, Sikkink SK, Mine S, Freis O, Danoux L, Tobin DJ. Sci Rep. 2020 Oct 30;10(1):18711. doi: 10.1038/s41598-020-75334-9.
  7. The biology of human hair greying, O'Sullivan JDB, Nicu C, Picard M, Chéret J, Bedogni B, Tobin DJ, Paus R.  Biol Rev Camb Philos Soc. 2020 Sep 23. doi: 10.1111/brv.12648. Epub ahead of print.
  8. Ewastools: Infinium Human Methylation BeadChip pipeline for population epigenetics integrated into Galaxy, Murat K, Grüning B, Poterlowicz PW, Westgate G, Tobin DJ, Poterlowicz K. Gigascience. 2020 May 1;9(5):giaa049. doi: 10.1093/gigascience/giaa049. PMID: 32401319; PMCID: PMC7219210.
  9. Isolation of Epidermal Keratinocytes from Human Skin: The Scratch-Wound Assay for Assessment of Epidermal Keratinocyte Migration, Castellano-Pellicena I, Thornton MJ, Methods Mol Biol. 2020;2154:1-12. doi: 10.1007/978-1-0716-0648-3_1
  10. Characterization of serotonin and N-acetylserotonin systems in the human epidermis and skin cells,Slominski AT, Kim TK, Kleszczyński K, Semak I, Janjetovic Z, Sweatman T, Skobowiat C, Steketee JD, Lin Z, Postlethwaite A, Li W, Reiter RJ, Tobin DJ. J Pineal Res. 2020 Mar;68(2):e12626. doi: 10.1111/jpi.12626. Epub 2019 Dec 20. PMID: 31770455; PMCID: PMC7007327.
  11. A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia'. Adhikari K,..Tobin DJ..,F Ruiz-Linares A Nat Commun. 2019 Jan 21;10(1):358. doi: 10.1038/s41467-018-08147-0.
  12. Early evidence for opposing effects of full versus fragmented adiponectin on melanogenesis in human epidermal melanocytes, Tobin DJ. Br J Dermatol. 2018 Sep;179(3):561-562. doi: 10.1111/bjd.16909. PMID: 30222881.

 

 

Alumni

Former Staff Researchers

  • Gospel Nwikue (PhD)

 

TOP