UCD Conway Institute of Biomolecular and Biomedical Research Institiúid Mhic Con Mí an Taighde Bhithmhóilínigh agus Bhithleighis

'A Hitchhiker’s and Backpacker’s Guide to Therapeutics and Biomaterials Development'

Polymer or lipid-based therapeutic delivery systems are widely explored to improve the biological outcome of chemo and immunotherapy. However, poor vascular circulation, limited targeting and the inability to negotiate many biological barriers are key hurdles in their clinical translation. Biology has provided many examples of successful “carriers” in the form of circulatory cells, which routinely overcome the hurdles faced by synthetic carrier systems. We have explored “cellular hitchhiking and backpacking” approaches which involve combining synthetic particles with circulatory cells to drastically alter the in vivo fate of particles as well as the cells. I will provide an overview of the principles and applications of hitchhiking and backpacking approaches for therapeutic delivery, cell therapy and regenerative medicine. 

Biography: Samir Mitragotri is the Hiller Professor of Bioengineering and Hansjorg Wyss Professor of  Biologically Inspired Engineering  at Harvard University and Wyss Institute. His research is focused on therapeutic and biomaterial development. His research has led to new technologies for treating many diseases. He is an elected member of the US National Academy of Engineering, US National Academy of Medicine and US National Academy of Inventors. He is an author on over 400 publications and an inventor on over 300 patents/patent applications. His research has led to several companies that have advanced technologies developed by him into clinical and commercial products. He is also an elected fellow of AAAS, CRS, BMES, AIMBE, and AAPS. He received BS in Chemical Engineering from the Institute of Chemical Technology, India and PhD in Chemical Engineering from the Massachusetts Institute of Technology. 

'Genome regulation: shining light on the dark matter'

Precise regulation of gene expression is essential for almost all biological processes, and when it goes awry, can lead to a wide-range of human diseases.  Gene expression is initiated by enhancers, which are non-coding elements that recruit transcription factors to regulate when and where genes are expression.  As many enhancers are located upstream, downstream or in the introns of other genes, they need to come into physical proximity to their target gene.  What controls the specificity, timing and regulation of these enhancer-promoter ‘loops’ are current key questions.  I will discuss how we are combining genetics, single cell genomics and computational inference to dissect this during embryonic development.  These questions are fundamental to how our genomes are regulated, and have far reaching implications to understanding the impact of natural sequence variation on phenotypes such as speciation differences and susceptibility to disease. 

Biography:
Professor Eileen Furlong is a UCD graduate who completed her PhD (Pharmacology) under the supervision of Conway Emeritus Fellow, Prof. Finian Martin. Her groundbreaking research provides insights into the inter-relationships between the genome and the environment. Eileen is Head of the Genome Biology Department at the European Molecular Biology Laboratory (EMBL) and elected a member of the European Molecular Biology Organization (EMBO) in 2013, the Academia Europaea in 2016, EMBO’s research council in 2018, and was elected a Fellow of the Royal Society in 2022.

“The EPIC study in diet, nutrition and cancer”

The European Prospective Investigation into Cancer (EPIC) is a population-based prospective cohort, with 520,000 participants in 10 European countries, initiated in the 1990s to investigate the role of diet and nutrition in cancer aetiology. EPIC led to the identification of the role of several diet components in cancer causation (red meat, processed meat) and prevention (fruit, vegetables and all-grain cereals) and the discovery of the causal role of obesity and the protective effect of physical activity for several cancers.  EPIC studies on biological samples have supported the causal nature of these associations and contributed to the discovery of the role of metabolic deregulations related to insulin resistance and inflammation in the aetiology of several cancers.

Biography: Professor Elio Riboli is Chair in Cancer Epidemiology and Prevention at Imperial College London. He is also Founding Director of the Cancer Epidemiology and Prevention Research Unit, jointly established by Imperial College and the Institute for Cancer Research. Professor Riboli has made an exceptional impact on the fields of epidemiology, cancer prevention and the fight against chronic illness. While working at the International Agency for Research on Cancer of World Health Organisation, he initiated ground-breaking research on the role of diet, nutrition and metabolic health in cancer causation and prevention. He designed and led the establishment of the largest international population cohort studies on nutrition and cancer, the European Prospective Investigation into Cancer and Nutrition (EPIC) that recruited over half-a-million participants with rich phenotyping data and blood samples stored in the first dedicated large-scale population biobank.  

Assoc. Prof. Colm Ryan
UCD School of Medicine & Fellow, UCD Conway Institute 
‘Understanding and Predicting Synthetic Lethality in Cancer’

Assoc. Prof. Fiona Freeman
UCD School of Mechanical and Materials Engineering & Fellow, UCD Conway Institute 
‘Innovative Engineering Solutions for Osteosarcoma's Unmet Challenges’

Prof. Ulla Knaus
UCD School of Medicine & Fellow, UCD Conway Institute
‘The chemical gut environment - Fight, harm and heal’

Prof. Colm O’Donnell
UCD School of Medicine & National Maternity Hospital
TBC Title 

The 2024 UCD Conway Festival abstract call is now closed for (a) poster review and (b) Conway Gold Medal competitions. The Festival committee would like to thank all authors for their submissions.

The full listing of posters will be available here shortly.

The following authors have been shortlisted for the 2024 Conway Festival Gold Medal competition sponsored by Cruinn Diagnostics.

FRI_GM2        Dr Carlos Matellan [Manresa & Thorpe gps]
FRI_GM6        Tanwi Vartak [Brennan gp]
FRI_GM4        Ruth Haverty [Fletcher gp]
FRI_GM12      Dr Cosmin Tudose [Bond gp, Systems Biology Ireland]
FRI_GM14      Lorna O'Donoghue [Smolenski gp]

 

The Festival committee invites Conway PhD and postdoctoral researchers to submit abstracts for presentation at the 2024 UCD Conway Festival general poster session on Wednesday, 02 October.

All submitting authors will give a 5-minute outline of research including mention of innovative potential to a 2-person panel composed of senior postdoctoral researchers and/or Conway Fellows who will select posters for commendation and prizes.
 
Submit abstracts via Google form: 
Deadline: 5pm, Friday 02 August 2024