Testimonials & Case Studies

Key to the success of the UCD Conway core technology programme is our dedicated team of scientists and technical staff whose joint expertise ensures that our clients get the best quality service and the most out of their data.

By focusing on research questions with a ‘problem solving’ approach, our team find the best-fit solution tailored to the particular research needs of clients and will help with all aspects of project planning, execution and downstream data analysis. 

Research Question?

We wanted to do a method comparison for bead-based sandwich immunoassays between Radisens’ technology and the equipment within the flow cytometry core, to understand our competitive positioning.

‘The expertise in the flow cytrometry core has been very helpful in helping Radisens to validate the portable cytometer technology under development in-house. We were able to conduct method comparisons with a range of commercially available instruments. The guidance given on clinical use cases has further strengthened the company’s development.’

Mr Jerry O’Brien, CEO, Radisens Diagnostics

Research Question?

Can we make sensitive and quantitative measurements of intracellular calcium release in transfected cells?

‘The flow cytometry core has been very helpful in all aspects of the project, including the experimental setup, optimisation of measurements and data evaluation. This support has led to the successful generation of very clear and important new data.’

Dr Albert Smolenski, UCD

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Research Question?

Can we identify mutations associated with high level methicillin resistance in Staphylococcus aureus (MRSA)?

‘The service by the genomics core was excellent. It was much faster and more efficient than our previous experience using a commercial company. It was invaluable to have access to the expertise of scientists in the core when doing the sequencing and bioinformatic analysis.’

Professor Jim O’Gara, NUI Galway

Research Question?

Can we establish the transcriptomic profile of renal epithelial cells exposed to the profibrotic cytokine transforming growth factor beta (TGFB1) as an in vitro model of renal fibrosis?

‘The use of the genomics core is an invaluable service for our research into the mechanisms underlying renal fibrosis. In particular, as part of our RNA-seq experiment, we received considerable advice from staff on the design and execution of these experiments.’

Professor Catherine Godson, UCD ; Dr Eoin Brennan, postdoctoral fellow

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Research Question?

What happens to the ultrastructural morphology of intestinal epithelial cell monolayers after perturbation with an intestinal absorption enhancer and then on removal of the enhancer? What is the effect of mucosal injury and repair on localisation of tight junction and adherens junction proteins?

‘The core staff provide the highest level of expertise in microscopic techniques. They not only helped with study design by ensuring that the chosen microscopy was the correct option but they also outlined several other novel and established techniques that could help in answering the proposed scientific questions and progress the research’

Professor David Brayden, UCD & Irish Drug Delivery Network ; Dr Sam Maher, postdoctoral fellow

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Research Question?

Can we identify trace amounts of protein that stimulate cell migration?

‘Our attempt to map protein function in a delicate biofluid was a major challenge but the core staff designed a configuration that gave us the sensitivity we needed. The hardware in the MSR is world class, but it is the problem solving skills of the staff that makes the difference.’

Dr Gerard Cagney, UCD

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Research Question?

Can we isolate murine photoreceptor cells to evaluate adeno- associated viral (AAV) based therapies for retinitis pigmentosa?
 
We have been successfully collaborating with the flow cytometry core director since 2005 to establish the parameters required to undertake this project. We have enjoyed a happy and productive relationship, as demonstrated by our publications.  We have always received the highest quality samples, which has resulted in the generation of robust data. 

Professor Jane Farrar, Trinity College Dublin; Dr Naomi Chadderton, postdoctoral fellow