Research Theme: Cognitive Functioning

 

Name:  Angelina Sutin

Institution:  Florida State University College of Medicine

Contact: Angelina.sutin@med.fsu.edu

Completion:  July 2022

Funder: N/A

 

Project: The purpose of the proposed project is to examine the association between personality and cognition.  Personality traits have been shown to be associated with risk of Alzheimers disease and other dementias.  Less is known about its association with specific aspects of cognitive functioning particularly in different cultural contexts.  With data from Tilda, we would like to examine different associations between personality and memory and mental status and whether associations are similar or different from those found in samples from the United States.

This project is also recorded under the theme Mental Health

 

Name:  Anna Syperek

Institution:  Ulster University

Contact: spirek-a1@ulster.ac.uk

Completion:  September 2018

Funder: N/A

 

Project: Analysis of Wave 1 data in order to complete a research dissertation as part of the requirement of the Msc Applied Psychology course at Ulster University.  Aim of the study is to investigate the influence of menopause and prescription hormones on cognition as different ageing sub groups.  My supervisor and I definitely need variables PH703-PH707 as well as demographic variables and health variables, mental health and cognition variables.  Ideally we would like as many variables as possible.

 

 

Name:  Sohaib Asghar

Institution:  University of Sheffield

Contact: sasghar1@sheffield.ac.uk

Completion:  September 2017

Funder: N/A

 

Project: Data will be used to estimate prevalence and characteristics of older adults without living family members in contemporary Ireland. Aggregate results will be compared to estimates from other countries to form a cross-national comparative case study in the contemporary prevalence, characteristics, and causes of older adult social isolation.

 

 

Name:  Ruth Peters

Institution:  Australian National University

Contact: Rthpeters@googlemail.com

Completion:  December 2018

Funder: N/A

 

Project: We have evidence that higher blood pressure is likely to increase our risk of developing dementia or worsening thinking and memory skills (cognitive decline) later in life. There are also several studies and clinical trials that have looked at giving blood pressure lowering drugs and whether this will reduce risk of dementia or cognitive decline. The results of these studies are mixed. It has been suggested that the mixed results are due to the different types of blood pressure lowering drugs used in the different studies and trials. That is to say, some types of blood pressure lowering drugs may have a more positive effect on risk of dementia or cognitive decline than others. We are looking at the different types of blood pressure lowering drugs in a large number of studies. We are combining the results to see whether there are any differences depending on the type of blood pressure lowering drug that is used. For this reason we are applying to look at the TILDA data to see whether the different types of blood pressure lowering drugs had different effects on the development of cognitive decline and dementia.

This project is also recorded under the theme Drug Treatment

 

Name:  Ryan Johnston

Institution:  University College Dublin

Contact: ryan.johnston@ucdconnect.ie

Completion:  October 2018

Funder: N/A

 

Project: I am planning to use the datasets to track the cognitive decline of the study participants in relation to the amount of caregiver assistance they report receiving from other people. I am interested to see if those who have more contact with caregivers experience a slower cognitive decline or have a better cognitive situation as time progresses. With the increased use of palliative care for non-end of life situations, I believe that it could be helpful to show that a more comprehensive caregiver experience creates better situations for these people, and that palliative care could be extended as another option to help slow cognitive decline.

 

Name:  Jacqui Smith

Institution:  University of Michigan

Contact: smitjacq@umich.edu

Completion:  Dec 2022

Funder: N/A

 

Project: Our research group on Cognitive and Psychosocial Aging, affiliated with the Health and Retirement Study (HRS), has a subcontract to assist the USC-based NIH-Funded project on Global Aging (PI Lee), to harmonize measures of stress and psychosocial functioning collected in the HRS-related studies around the world. In the context of this project, we will also be writing papers to reporting country (cultural) differences in associations between health outcomes and various psychsocial constructs (including loneliness, subjective well-being, self-perceptions of aging, and stress).

 

Name:  Claudia Suemoto

Institution:  University of Sao Paulo

Contact: cksuemoto@usp.br

Completion:  May 2018

Funder:  Global Brain Health Institute

 

Project: We plan to use data from six cohorts: The Irish Longitudinal Study on Ageing (TILDA), Japanese Study of Ageing and Retirement (JSTAR), ELSA (English Longitudinal Study of Ageing), HRS (Health and Retirement Study), MHAS (Mexican health and ageing study, CRELES (Costa Rica Longevity and Health Ageing Study), and SHARE (Survey on Health, Ageing and Retirement in Europe). We will split the pooled data into training (two-thirds) and test (one third) datasets. Baseline predictors included age, sex, and comorbidities. Dementia will be defined by the presence of poor cognitive performance (performance <2 SD in cognitive tests) and functional impairment (presence of impairment in ADL). We will perform an individual participant data meta-analysis using a sex-stratified Cox proportional hazards model, with time to dementia as the time scale.

 

Name:  Lidia Alexandra Martinez Rodriguez

Institution:  Trinity College Dublin

Contact: lmartine@tcd.ie

Completion:  31/06/2021

Funder: N/A

 

Project: The results of the study will be used for my final year Master's project. The objectives of the proposed research are as follows: 1) to resolve changes in brain connectivity accompanying grip strength decline; 2) to determine the changes in brain connectivity that mediate the relationship between grip strength trajectories and cognitive decline; 3) To define the aspects of brain function for which grip strength provides the most robust early biomarkers.

 

Name: Withheld
Institution: Withheld
Contact: Withheld
Completion: Withheld

 

Project (2017):  We aim to compare a cohort of COPD patients in Beaumont hospital to norms in terms of scores on brief neuropsychology measure (ie.MOCA). This is part of a feasibility study looking at the impact of cognitive impairment on medication adherence in COPD patients.

 

Name: Withheld
Institution: Withheld
Contact: Withheld
Completion: Withheld

 

Project (2017): This study aims to examine the relationship between childhood social adversity and later life social functioning. Having identified appropriate variables a secondary analysis of the TILDA data using SPSS will be conducted. Univariate and Bivariate analysis of variables will be conducted followed by the construction of a hierarchal regression model. The ultimate aim of which is to test the hypothesis that childhood social adversity negatively impacts on later life social functioning.

 

Name: Marica Cassarino
Institution: University College Cork
Contact: mcassarino@ucc.ie
Completion: July 2017

Project: The datasets will be used to conduct cross-sectional analyses for TILDA wave 2 as well as longitudinal analyses (confronting wave 1 and wave 2) of measures of cognitive performance in the CAPI in relation to location of residence (urban vs. rural), while controlling for socioeconomic, health, and lifestyle factors. These analyses are part of a PhD project which started in October 2013. Cross-sectional analyses of TILDA Wave 1 have already been conducted by using the first public release (access granted at the beginning of 2014), but an updated version would be useful to check whether substantial changes have been made to the used variables. 

 

Name: Iseult Cremen
Institution: Trinity College Dublin
Contact: cremeni@tcd.ie
Completion: September 2016

Project: I am PhD candidate at TCD and I am looking into novel motor-training interventions to prevent and/or delay cognitive decline and improve cognitive functioning in older adults. As part of my protocol, I am replicating a subset of the TILDA cognitive and motor tests, and it would be hugely beneficical to my research to have population norms with which to compare my data. 

 

Name: Rose Galvin
Institution: University of Limerick
Contact: rose.galvin@ul.ie
Completion: March 2016

Project: Previous research indicates that measures of cognitive function are lower in adults with lower levels of formal education. In Ireland, the mean normative scores MoCA scores are eported to be 23.1 points (SD 3.9 points) in adults with primary or no education. We hypothesise that adults with Chronic Obstructive Pulmonary Disease (COPD) have lower MoCA scores than their age and gender matched norms. Therefore the purpose of this study is to compare MoCA scores of COPD patients (recruited from the outpatient department of an urban teaching hospital in Dublin) with Irish norms, as described in the TILDA study. 

 

Name: Anja Leist
Institution: University of Luxembourg
Contact: anja.leist@uni.lu
Completion: February 2022

Project: Examining the education-cognition gradient across countries and cohorts with the different health and retirement studies

 

Name: Avril Mansfield
Institution: Toronto Rehabilitation Institute
Contact: avril.mansfield@uhn.ca
Completion: March 2017

Project: Fear of Falling (FOF) is common in older adults, and while it sometimes develops as a result of a fall, it can also develop people without a history of falls. Therefore, there is a potential for FOF to afflict a large proportion of the older adult population. FOF often leads to reduced functional independence and quality of life, as people may avoid activities that they were previously able to perform. FOF has typically been studies in the context of everyday activities, including standing and walking. However, there has been little work to examine the effects of FOF in an occupational context, and if FOF affects individual's capacity to continue working in the later years. Therefore, the purpose of this study is to determine whether older working individuals with fear of falling were more likely to be retired at the end of a two year follow-up period, compare to those without fear of falling. We hypothesise that older working individuals with fear of falling will be more likely to be retired at the end of a two year follow up period. The measures required for analysis and/or as cohort descriptors will consist of fear of falling, employment status, age, sex, and the type of employment/industry. Participants in the fear and no-fear groups will be matched on age and sex. The fear and no-fear groups will then be compared to determine whether people in the fear group who were initially employed during the initial period of data collection, were more likely than those in the no-fear group to be retired by the follow-up period of data collection. 

 

Name: Fiachra Maguire
Institution: Trinity College Dublin
Contact: fmaguire@tcd.ie
Completion: Withheld

Project: To assess if gait is a predictor of cognitive decline in a nationally representative community dwelling population (TILDA Wave 1, wave 2). This analysis is undertaken with a view to assessing if a modified Motoric Cognitive RISK (MCR), as defined by the Einstein Ageing Study, can be developed from TILDA (using different gait and/or cognitive function variables) employing TILDA wave 1 and wave 2. This will also involve the examination of (1) cross sectional and longitudinal differences in gait between cognitive function groups based on neuropsychological assessment test scores and diagnosis of serious memory impairments (2) interaction between age, gait, global cognition groups and cognitive impairment. This is an extension of previous research carried out into the correlations between gait and cognition function parameters in the TILDA dataset. Analysis will be carried out to support TILDA research output and in conjunction with the Physical Health and Neuropsychology Working Groups.

 

Name: Joanna Edel McHugh
Institution: Trinity College Dublin
Contact: j.mchugh@qub.ac.uk
Completion: September 2017

Project: I am investigating the link between social factors (social connectedness, participation, and loneliness) and cognitive outcomes, as mediated by health, health behaviours, mood, and stress. I aim to use structural equation modelling on the TILDA dataset to test the theoretically-derived model I have created of the link between social factors and cognitive outcomes.

 

Name: Aine Ryan
Institution: Royal College of Surgeons in Ireland
Contact: aineryan@rcsi.ie
Completion: July 2016

Project: We aim to identify the impact of levels of activity and function on the development of multimorbidity (>2 chronic conditions). Levels of activity and function will be identified using the following outcome measures: IPAQ; Timed up and Go; Grip Strength and Gait Speed. These will be considered individually and in combination. Data from wave 1 through to wave 2 will provide information on the baseline presence of chronic conditions and their subsequent development. We also intend to identify the impact of levels of activity and function on patients with multimorbidity over time. Those patients with established multimorbidity at Wave 1 will be followed through to Wave 2. The worsening of multimorbidity will be analysed in terms of accrual of additional chronic conditions. Secondary outcomes which will also be examined are quality of life and healthcare utilisation. Quality of life will be measured using the results from the CASP-19 questionnaire. Healthcare utilisation will be assessed via the computer-aided personal interview (CAPI) questions specific to the Irish healthcare system on the use of healthcare services and individual healthcare expenses. 

 

Name: Elizabeth Saunders
Institution: University of Washington
Contact: elizsand@u.washington.edu
Completion: September 2020

Project: A number of surveys of health and cognition in older adults conducted outside of the US are modelled after the US Health and Retirement Study (HRS). Each of these international sister studies (ISS) uses different methods to assess cognitive functioning. These differences, combined with differences in the environment, languages, demographic and health characteristics of the participants make it difficult to draw clear conclusions regarding similarities and differences in the level of cognitive impairment cross-nationally. The ability to compare rates of dementia and more broadly cognitive impairment internationally is of interest to policy makers and public health leaders. Health ministries require reliable information regarding the comparative burden and potential impact of cognitive impairment among their older citizens to evaluate previous public responses and plans for future responses to demographic shifts. Our project will: 1) harmonize and co-calibrate the cognitive assessments in the HRS family of studies, 2) identify limits of the validity of the measures, 3) and make concrete recommendations for future work and instrument development. We will accomplish these goals by making use of HRS and ISS, as well as other existing studies that include brief mental status assessments, neuropsychological tests, and relevant clinical outcomes for cognitive aging and dementia (neuroimaging, neuropathology, and longitudinal course).

 

Name: Withheld
Institution: Withheld
Contact: Withheld
Completion: Withheld

Project: I wish to explore the association between balance and physical activity (PA) and understand whether PA has any protective factors regarding balance over time using studies such as NICOLA, ELSA and TILDA.

This research project is also recorded under the theme: Physical Activity.

 

Name: Withheld
Institution: Withheld
Contact: Withheld
Completion: December 2016

Project: The aim is to analyse data from TILDA to estimate the prevalence and incidence of falls among older people with diabetes in Ireland and examine whether there is an independent association between diabetes and falls in this group. The prevalence of falls, recurrence and fear of falling will be estimated among people with and without diabetes. Using data from waves 1 and 2 of the study, the incidence of falling in this population will be compared to the general population without diabetes. Multivariate logic regression will be used to examine the independent association between diabetes and the occurrence of falls, adjusting for potential confounding factors including age, cardiovascular events (MI, stroke, angina), cerebrovascular disease, hypertension, exercise, education levels, physical functioning and polypharmacy. Sub-group analysis will be conducted to identify the risk factors associated with falling among those within the diabetic population. 

This research project is also recorded under the theme: Health.

 

Name: Withheld
Institution: Withheld
Contact: Withheld
Completion: Withheld

Project: I wish to investigate hearing with a team of final year Speech and Language Therapy students. For example, the relationship between hearing and language and cognitive function in older adults; use of hearing aids by older Irish adults with hearing difficulties; the relationship between job history, employment, retirement and hearing in later life; the relationship between childhood health and hearing function in later life; the relationship between behavioural health and hearing function in older adults; the relationship between mental health and hearing in later life; the relationship between falls and hearing function in older adults; the association between social relationships and hearing function in older adults; the relationship between social participation and hearing function in older adults; the relationship between activities of daily living and hearing function in older adults and the relationship between cardiovascular diseases and hearing function.

This research project is also recorded under the theme: Health.

 

Name: Withheld
Institution: Withheld
Contact: Withheld
Completion: December 2015

Project: The TILDA dataset and its variables will be used to research two questions: do older metabolically healthy obese (MHO) individuals have a reduced prevalence of cognitive impairment when compared with age and BMI matched MUO individuals? Do older MHO individuals have better functional capacity when compared with age and BMI matched MUO individuals? 

This research project is also recorded under the theme: Weight and Dietary Issues.

 

Name: Withheld
Institution: Withheld
Contact: Withheld
Completion: May 2016

Project: To use for final year Dietetics undergraduate project, looking at handgrip strength and performance associated factors i.e. BMI, physical activity, age in community dwelling older adults.

 

Name: Withheld
Institution: Withheld
Contact: Withheld
Completion: December 2018

Project: The proposed doctorate aims to discover and analyse the relationships between the behaviours of alcohol consumption and smoking and the psychosocial variables of depression, anxiety, suicidal ideation, insomnia, social connectedness and cognitive functioning in an older population (aged 65 and above). 

This research project is also recorded under the theme: Mental Health and Alcohol Consumption and Smoking

 

Name: Withheld
Institution: Withheld
Contact: Withheld
Completion: 2015

Project: We would like to examine physical limitations and cognitive abilities of the population above 50 across countries. Moreover, investigations in possible cohort changes in terms of disabilities and cognition are of our interest.

This research project is also recorded under the theme: Disability

 

Name: Withheld
Institution: Withheld
Contact: Withheld
Completion: July 2016

Project: We are conducting research on mental health and social network. We are going to analyze the TILDA data in order to identify the factors associated with mental health, cognitive impairment and social network. 

This research project is also recorded under the theme: Mental Health and Community and Social Support.

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