Calcium Attenuates Impact of Vitamin D Inadequacy on Bone Turnover in Winter Pregnancy
Congratulations to Ms Eileen O’Brien, PhD Student with the UCD Maternal & Fetal Health Group, who won the oral prize for Maternal Medicine at The British Maternal & Fetal Medicine Society’s 18th Annual Conference held in Birmingham on 21st & 22nd April 2016. Ms O'Brien presented on a study entitled ‘Calcium attenuates impact of vitamin D inadequacy on bone turnover in winter pregnancy’.
Pregnancy is characterised by increased bone turnover, but high bone turnover with resorption exceeding formation may lead to maternal negative bone remodelling. Studies are conflicting regarding the effect of calcium on maternal skeletal health in pregnancy; therefore, further investigation is required in this field. This study aimed to examine the seasonal effect of serum 25-hydroxyvitamin D (25OHD) and dietary calcium on a marker of bone resorption.
The findings suggest that in late pregnancy during winter months when 25OHD is inadequate, intakes of dietary calcium <1000 mg/day are associated with significantly increased bone resorption, in keeping with the known interdependence between calcium and vitamin D intakes. Additional dietary calcium is associated with reduced bone resorption in late pregnancy, with greater effect observed in winter. Dietary calcium and 25OHD should be optimised in pregnancy, particularly in women gestating through winter.
Authors : Eileen C O’Brien1, Mark T Kilbane2, Malachi J McKenna2, Ricardo Segurado3, Aisling A Geraghty1, Fionnuala M McAuliffe1
- UCD Obstetrics & Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland
- Metabolism Laboratory, St Vincent’s University Hospital, Dublin, Ireland
- Centre for Support and Training in Analysis and Research (CSTAR), School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland