Dr Dearbhaile Dooley PhD, BSc
| Upon completion of a BSc in Anatomy from NUI Galway, Dr Dooley relocated to Belgium to undertake a PhD/Anatomy Teaching position at Hasselt and Antwerp Universities, in the field of inflammation and CNS trauma. Dr Dooley's PhD research focused on the use of stem cells and immunomodulatory mediators as therapeutic factors for spinal cord injury. During this time, she was also involved in teaching anatomy to medical and biomedical students.
Dr Dooley returned to Ireland to join the Renal Inflammation Group at Trinity College Dublin as a Postdoctoral Research Fellow, where she investigated the role of monocytes in a humanised mouse model of ANCA Vasculitis. In 2017, she joined UCD School of Medicine as Assistant Professor in Human Anatomy, where she teaches anatomy to undergraduate and graduate-entry medicine as well as allied health students. Her research investigates the inflammatory response after CNS trauma, with a particular focus on the role of monocytes/macrophages and microglia.
| Over two million people are affected by spinal cord injury (SCI) worldwide leading to severe motor, sensory and autonomic dysfunction as well as a diminished quality of life. Following SCI, pro-inflammatory resident microglia and infiltrating macrophages dominate the pathological environment and can exert beneficial or detrimental effects, depending on their activation state.
The major focus of my research lies in understanding what drives these microglia/macrophage activation states and how we can modulate them during the inflammatory response. By using a wide variety of multidisciplinary techniques, we are investigating how the use of advanced drug delivery systems may induce immunomodulation and ultimately improve functional recovery.
Current Postgraduate Students
|Brendan O Donnell, Doctor of Philosophy (PhD) - Thesis Supervisor|
Peer Reviewed Journals
|Fazekasa B Moreno-Olivera A, Kelly Y, O¿Hara P, Murray S, Kennedy A, Conlon, N, Dooley D, O¿Brien EC, Moran S, Doherty DG, Little MA (2017) 'Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific manifestations of renal injury'. Clinical and Experimental Immunology, . [Details]|
|Schönfeld LM, Jahanshahi A, Lemmens E, Schipper S, Dooley D, Joosten E, Temel Y, Hendrix S. (2017) 'Long-Term Motor Deficits after Controlled Cortical Impact in Rats Can Be Detected by Fine Motor Skill Tests but Not by Automated Gait Analysis'. Journal of Neurotrauma, . [Details]|
|Dooley D, Lemmens E, Vangansewinkel T, Le Blon D, Hoornaert C, Ponsaerts P, Hendrix S. (2016) 'Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury'. Stem Cell Reports, . [Details]|
|Le Blon D, Guglielmetti C, Hoornaert C, Quarta A, Daans J, Dooley D, Lemmens E, Praet J, De Vocht N, Reekmans K, Santermans E, Hens N, Goossens H, Verhoye M, Van der Linden A, Berneman Z, Hendrix S, Ponsaerts P. (2016) 'Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model'. Journal of Neuroinflammation, . [Details]|
|Dooley D, Lemmens E, Ponsaerts P, Hendrix S. (2016) 'Interleukin-25 is detrimental for recovery after spinal cord injury in mice'. Journal of Neuroinflammation, . [Details]|
|Hoornaert CJ, Luyckx E, Reekmans K, Dhainaut M, Guglielmetti C, Le Blon D, Dooley D, Fransen E, Daans J, Verbeeck L, Quarta A, De Vocht N, Lemmens E, Goossens H, Van der Linden A, Roobrouck VD, Verfaillie C, Hendrix S, Moser M, Berneman ZN, Ponsaerts P. (2016) 'In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants'. Stem Cells, . [Details]|
|Vangansewinkel T, Geurts N, Quanten K, Nelissen S, Lemmens S, Geboes L, Dooley D, Vidal PM, Pejler G, Hendrix S. (2016) 'Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6'. FASEB Journal, . [Details]|
|Lemmens S, Brône B, Dooley D, Hendrix S, Geurts N. (2015) 'Alpha-adrenoceptor modulation in central nervous system trauma: pain, spasms, and paralysis--an unlucky triad'. Medicinal Research Reviews, . [Details]|
|Nelissen S, Vangansewinkel T, Geurts N, Geboes L, Lemmens E, Vidal PM, Lemmens S, Willems L, Boato F, Dooley D, Pehl D, Pejler G, Maurer M, Metz M, Hendrix S. (2014) 'Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4'. Neurobiology of Disease, . [Details]|
|Dooley D, Vidal P, Hendrix S. (2014) 'Immunopharmacological intervention for successful neural stem cell therapy: New perspectives in CNS neurogenesis and repair'. Pharmacology and Therapeutics, . [Details]|
|Vidal PM, Lemmens E, Dooley D, Hendrix S. (2013) 'The role of anti-inflammatory cytokines in axon regeneration'. Cytokine & growth factor reviews, . [Details]|
|Association: Royal Academy of Medicines Ireland, Function/Role: Member|
| Prof. James Jones
School of Medicine: Anatomy
Dr Mark Pickering
School of Medicine: Anatomy & Physiology
Prof. David Brayden
Conway Institute of Biomolecular & Biomedical Research
| Prof. Sven Hendrix
Hasselt University, Belgium
Prof. Peter Ponsaerts
University of Antwerp, Belgium
Dr Siobhan McMahon
National University of Ireland, Galway