Fibrosis

Theme Overview

The UCD School of Medicine and Medical Sciences (SMMS) strategy for research support is to facilitate the coming together of individual investigators to create a coherent research group with a critical mass that can be efficiently supported and which can collaborate with industry and other academic institutions. The fibrosis group has obtained commitments from colleagues in UCD and affiliated hospitals to move this collaborative research agenda forward. The group represents a cross-section of UCD Fibrosis research interests.

The Fibrosis group includes active PIs concentrated on developing our understanding of molecular, cellular, tissue and whole organism aspects of fibrosis. Specific current research clusters exist in the areas of cancer biology, hypoxia in disease, molecular vascular biology and proteomics/bioinformatics.

More Information About Fibrosis Research at UCD

The vascular system including blood vessels, blood cells, coagulation pathways, bone marrow and stems cells plays a central role in the development and progression of many major diseases including atherosclerosis, stroke, inflammatory lung disease, arthritis, cancer and complications of diabetes. Our focus is to enhance our understanding of the pathophysiology fibrosis and particularly the role of vascular involvement in fibrosis in order to identify and develop novel treatments and prevention strategies.

Particular areas of strength include:

  • Hypoxia responses in adaptation and disease
  • Angiogenesis in inflammatory diseases
  • Microvascular complications of diabetes
  • Coagulation pathways in cardiovascular disease
  • Pulmonary hypertension
  • Biology of fibrocytes

Key Achievements in 2012:

  • The Fibrosis group have published over 50 peer reviewed publications, while securing Euro 7 million in funding.

Research Team

Prof Michael Keane
Professor of Medicine and Therapeutics

Prof Colm O’ Brien
Consultant and Professor of Ophthalmology

Dr John Baugh
Lecturer in Medicine

Dr Marcus Butler
Consultant and Lecturer in Respiratory Medicine

Dr Seamas Donnelly
Consultant and Lecturer in Respiratory Medicine

Dr Suzanne Donnelly
Consultant Rheumatologist and Director of Clinical Education

Dr Margaret Hannan
Senior Clinical Lecturer

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Dr Katherine Howell
Lecturer in Medicine

Prof Geraldine McCarthy
Clinical Professor

Prof Paul McLoughlin
Professor of Physiology

Dr Deborah Wallace
Postdoctoral Research Fellow

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