UCD Biomolecular & Biomedical Science
UCD School of Biomolecular & Biomedical Science - Research Publications 2019/20
Below is the list of research publications for the UCD School of Biomolecular & Biomedical Science in the academic year 2019/20.
Below is the list of research publications for the UCD School of Biomolecular & Biomedical Science in the academic year 2019/20.
| Dr David Hughes | |
| Hughes D; Fedirko V; Schomburg L; Hybsier S; Méplan C; Jenab M (2019) 'Association of selenium status and selenoprotein genetic variations with cancer risk.' In: Selenium Research for Environment and Human Health: Perspectives, Technologies and Advancements.Oxford, UK: CRC Press, Taylor & Francis. , pp.165-166 | |
| Professor Cormac Murphy | |
| Murphy C; Phelan A (2020) 'Microbial Biotransformations in the Production and Degradation of Fluorinated Pharmaceuticals' In: Pharmaceutical Biocatalysis Drugs, Genetic Diseases, and Epigenetics.Singapore: Jenny Stanford Publishing. | |
| Dr Emmanuel Reynaud | |
| Reynaud E; Gabriel O-C; Yolanda G-C (Ed.). (2020) Special Issue "Imaging Sensor Systems for Analyzing Subsea Environment and Life". China: MDPI | |
| Professor Orina Belton | |
Bruen R; Curley S; Kajani S; Lynch G; O'Reilly ME; Dillon ET; Fitzsimons S; Mthunzi L; Mcgillicuddy FC; Belton O (2019) 'Different monocyte phenotypes result in proresolving macrophages in conjugated linoleic acid-induced attenuated progression and regression of atherosclerosis'. FASEB Journal 33 (10) :11006-11020. |
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| Assoc Professor Oliver Blacque | |
| Akella JS; Carter SP; Nguyen K; Tsiropoulou S; Moran AL; Silva M; Rizvi F; Kennedy BN; Hall DH; Barr MM (2020) 'Ciliary rab28 and the BBSome negatively regulate extracellular vesicle shedding'. eLife 9 |
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| Alsolami M; Kuhns S; Alsulami M; Blacque OE (2019) 'ERICH3 in Primary Cilia Regulates Cilium Formation and the Localisations of Ciliary Transport and Sonic Hedgehog Signaling Proteins'. Scientific Reports 9 (1) |
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| Carter SP; Moran AL; Matallanas D; McManus GJ; Blacque OE; Kennedy BN (2020) 'Genetic Deletion of Zebrafish Rab28 Causes Defective Outer Segment Shedding, but Not Retinal Degeneration'. Frontiers in Cell and Developmental Biology 8 |
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| Kuhns S; Seixas C; Pestana S; Tavares B; Nogueira R; Jacinto R; Ramalho JS; Simpson JC; Andersen JS; Echard A (2019) 'Rab35 controls cilium length, function and membrane composition'. EMBO Reports 20 (10) |
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| Dr Gary Brennan | |
| Almeida Silva LF; Reschke CR; Nguyen NT; Langa E; Sanz-Rodriguez A; Gerbatin RR; Temp FR; De Freitas ML; Conroy RM; Brennan GP (2020) 'Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice'. Molecular Brain 13 (1) |
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| Batool A; Hill TDM; Nguyen NT; Langa E; Diviney M; Mooney C; Brennan GP; Connolly NMC; Sanz-Rodriguez A; Cavanagh BL (2020) 'Altered Biogenesis and MicroRNA Content of Hippocampal Exosomes Following Experimental Status Epilepticus'. Frontiers in Neuroscience 13 |
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| Reschke CR; Silva LFA; Vangoor VR; Rosso M; David B; Cavanagh BL; Connolly NMC; Brennan GP; Sanz-Rodriguez A; Mooney C (2019) 'Potent and lasting seizure suppression by systemic delivery of antagomirs targeting miR-134 timed with blood-brain barrier disruption'. |
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| Silva LFA; Reschke C; Nguyen N; Langa E; Rodriguez AS; Temp F; Freitas M; Gerbatin R; Conroy R; Brennan G (2020) 'Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice'. |
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| Venø MT; Reschke CR; Morris G; Connolly NMC; Su J; Yan Y; Engel T; Jimenez-Mateos EM; Harder LM; Pultz D (2020) 'A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy'. Proceedings of the National Academy of Sciences of the United States of America 117 (27) :15977-15988. |
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| Professor Geraldine Butler | |
| de San Vicente KM; Schröder MS; Lombardi L; Iracane E; Butler G (2019) 'Correlating Genotype and phenotype in the asexual yeast Candida orthopsilosis implicates ZCF29 in sensitivity to caffeine'. G3: Genes, Genomes, Genetics 9 (9) |
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| Gonçalves B; Bernardo R; Wang C; Schröder MS; Pedro NA; Butler G; Azeredo J; Henriques M; Pereira Mira N; Silva S (2020) 'Effect of progesterone on Candida albicans biofilm formation under acidic conditions: A transcriptomic analysis'. International Journal of Medical Microbiology 310 (3) |
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| Guin K; Chen Y; Mishra R; Muzaki SRBM; Thimmappa BC; O'brien CE; Butler G; Sanyal A; Sanyal K (2020) 'Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres'. eLife 9 |
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| Heneghan P; Ryan AP; Nimmo D; Duggan C; Kumar P; O’Gaora P; Cinnéide E; Byrne KP; Wolfe KH; O’Brien CE (2019) 'Draft Genome Sequence of the Birch Tree Fungal Pathogen Taphrina betulina UCD315'. Microbiology Resource Announcements 8 (48) |
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| Morio F; Lombardi L; Butler G (2020) 'The CRISPR toolbox in medical mycology: State of the art and perspectives'. PLoS pathogens 16 (1) :e1008201. |
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| Morio F; O’Brien CE; Butler G (2020) 'Draft Genome Sequence of the Yeast Kazachstania telluris CBS 16338 Isolated from Forest Soil in Ireland'. Mycopathologia 185 (3) :587-590. |
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| Ola M; O'Brien CE; Coughlan AY; Ma Q; Donovan PD; Wolfe KH; Butler G (2020) 'Polymorphic centromere locations in the pathogenic yeast Candida parapsilosis'. Genome Research 30 (5) :684-696. |
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| Zhai B; Ola M; Rolling T; Tosini NL; Joshowitz S; Littmann ER; Amoretti LA; Fontana E; Wright RJ; Miranda E (2020) 'High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis'. Nature Medicine 26 (1) :59-64. |
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| Dr Annette Therese Byrne | |
| Dienstmann R; Connor K; Byrne AT (2020) 'Precision Therapy in RAS Mutant Colorectal Cancer'. Gastroenterology 158 (4) :806-811. |
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| Fridman WH; Miller I; Sautès-Fridman C; Byrne AT (2020) 'Therapeutic Targeting of the Colorectal Tumor Stroma'. Gastroenterology 158 (2) :303-321. |
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| Miller IS; Shiels LP; Conroy E; Connor K; Dicker P; Gallagher WM; Donovan NO; Kerbel RS; Crown J; Byrne AT (2019) 'Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents'. Scientific Reports 9 (1) |
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| Noonan JJ; Jarzabek M; Lincoln FA; Cavanagh BL; Pariag AR; Juric V; Young LS; Ligon KL; Jahns H; Zheleva D (2019) 'Implementing patient-derived xenografts to assess the effectiveness of cyclin-dependent kinase inhibitors in glioblastoma'. Cancers 11 (12) |
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| White K; Connor K; Clerkin J; Murphy BM; Salvucci M; O'Farrell AC; Rehm M; O'Brien D; Prehn JHM; Niclou SP (2020) 'New hints towards a precision medicine strategy for IDH wild-type glioblastoma'. Annals of Oncology |
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| Dr Gerard Cagney | |
| Gordon DE; Watson A; Roguev A; Zheng S; Jang GM; Kane J; Xu J; Guo JZ; Stevenson E; Swaney DL (2020) 'A Quantitative Genetic Interaction Map of HIV Infection'. Molecular Cell 78 (2) :197-2090000000. |
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| Molloy K; Cagney G; Dillon ET; Wynne K; Greene CM; McElvaney NG (2020) 'Impaired Airway Epithelial Barrier Integrity in Response to Stenotrophomonas maltophilia Proteases, Novel Insights Using Cystic Fibrosis Bronchial Epithelial Cell Secretomics'. Frontiers in Immunology 11 |
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| Molloy K; Smith SG; Cagney G; Dillon ET; Greene CM; McElvaney NG (2019) 'Characterisation of the major extracellular proteases of Stenotrophomoas maltophilia and their effects on pulmonary antiproteases'. Pathogens 8 (3) |
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| Mongan D; Föcking M; Healy C; Susai SR; Heurich M; Wynne K; Nelson B; McGorry PD; Amminger GP; Nordentoft M (2020) 'Development of Proteomic Prediction Models for Transition to Psychotic Disorder in the Clinical High-Risk State and Psychotic Experiences in Adolescence'. JAMA Psychiatry |
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| Dr Hilary Cassidy | |
| Cassidy H; Slyne J; Higgins M; Radford R; Conlon PJ; Watson AJ; Ryan MP; McMorrow T; Slattery C (2019) 'Neutrophil gelatinase-associated lipocalin (NGAL) is localised to the primary cilium in renal tubular epithelial cells - A novel source of urinary biomarkers of renal injury'. Biochimica et Biophysica Acta - Molecular Basis of Disease 1865 (12) |
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| Doumandji Z; Safar R; Lovera-Leroux M; Nahle S; Cassidy H; Matallanas D; Rihn B; Ferrari L; Joubert O (2020) 'Correction to: Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles (Cell Biology and Toxicology, (2020), 36, 1, (65-82), 10.1007/s10565-019-09484-6)'. Cell Biology and Toxicology 36 (4) :387. |
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| Doumandji Z; Safar R; Lovera-Leroux M; Nahle S; Cassidy H; Matallanas D; Rihn B; Ferrari L; Joubert O (2020) 'Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles'. Cell Biology and Toxicology 36 (1) :65-82. |
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| Nahle S; Cassidy H; Leroux MM; Mercier R; Ghanbaja J; Doumandji Z; Matallanas D; Rihn BH; Joubert O; Ferrari L (2020) 'Genes expression profiling of alveolar macrophages exposed to non-functionalized, anionic and cationic multi-walled carbon nanotubes shows three different mechanisms of toxicity'. Journal of Nanobiotechnology 18 (1) |
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| Obaidi I; Cassidy H; Gaspar Ibanez V; McCaul J; Higgins M; McMorrow T (2020) 'Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4'. Biology Open |
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| Royds J; Conroy MJ; Dunne MR; Cassidy H; Matallanas D; Lysaght J; McCrory C (2020) 'Examination and characterisation of burst spinal cord stimulation on cerebrospinal fluid cellular and protein constituents in patient responders with chronic neuropathic pain - A Pilot Study'. Journal of Neuroimmunology 344 |
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| Useckaite Z; Ward MP; Trappe A; Reilly R; Lennon J; Davage H; Matallanas D; Cassidy H; Dillon ET; Brennan K (2020) 'Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis'. Thorax 75 (6) :449-458. |
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| Zhernovkov V; Santra T; Cassidy H; Rukhlenko O; Matallanas D; Krstic A; Kolch W; Lobaskin V; Kholodenko BN (2019) 'An Integrative Computational Approach for a Prioritization of Key Transcription Regulators Associated with Nanomaterial-Induced Toxicity'. Toxicological Sciences 171 (2) :303-314. |
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| Dr Federico Cerrone | |
| Cerrone F; Radivojevic J; Nikodinovic-Runic J; Walsh M; Kenny ST; Babu R; O'Connor KE (2019) 'Novel sodium alkyl-1,3-disulfates, anionic biosurfactants produced from microbial polyesters'. Colloids and Surfaces B: Biointerfaces 182 |
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| Dr Colm Collins | |
| Collins CB; Roche HM (2020) 'Personalized Nutrition for Inflammatory Bowel Disease'. Crohn's & Colitis 360 2 (3) |
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| Dr Derek Costello | |
| Howe AM; Cosgrave A; Ó'Murchú M; Britchfield C; Mulvagh A; Fernandez-Perez I; Dykstra M; Jones AC; Costello DA (2020) 'Characterising lipoteichoic acid as an in vitro model of acute neuroinflammation'. International Immunopharmacology 85 |
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| Holger Alexander Ebhardt | |
| Janacova L; Faktor J; Capkova L; Paralova V; Pospisilova A; Podhorec J; Ebhardt HA; Hrstka R; Nenutil R; Aebersold R (2020) 'SWATH-MS Analysis of FFPE Tissues Identifies Stathmin as a Potential Marker of Endometrial Cancer in Patients Exposed to Tamoxifen'. Journal of Proteome Research 19 (7) :2617-2630. |
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| Professor William Gallagher | |
| Aviello G; Singh AK; O’Neill S; Conroy E; Gallagher W; D’Agostino G; Walker AW; Bourke B; Scholz D; Knaus UG (2019) 'Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects'. Mucosal Immunology 12 (6) :1316-1326. |
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| Baird RD; van Rossum AGJ; Oliveira M; Beelen K; Gao M; Schrier M; Mandjes IAM; Garcia-Corbacho J; Vallier AL; Dougall G (2019) 'POSEIDON trial phase 1B results: Safety, efficacy and circulating tumor DNA response of the beta isoform-sparing PI3K inhibitor taselisib (GDC-0032) combined with tamoxifen in hormone receptor positive metastatic breast cancer patients'. Clinical Cancer Research 25 (22) :6598-6605. |
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| Bajor M; Graczyk-Jarzynka A; Marhelava K; Kurkowiak M; Rahman A; Aura C; Russell N; Zych AO; Firczuk M; Winiarska M (2020) 'Triple combination of ascorbate, menadione and the inhibition of peroxiredoxin-1 produces synergistic cytotoxic effects in triple-negative breast cancer cells'. Antioxidants 9 (4) |
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| Buus R; Sestak I; Barron S; Loughman T; Fender B; Ruiz CL; Dynoodt P; Wang CJA; O’Leary D; Gallagher WM (2020) 'Validation of the OncoMASTR risk score in estrogen receptor–positive/HER2-negative patients: A TransATAC study'. Clinical Cancer Research 26 (3) :623-631. |
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| Daly HC; Conroy E; Todor M; Wu D; Gallagher WM; O'Shea DF (2020) 'An EPR strategy for bio-responsive fluorescence guided surgery with simulation of the benefit for imaging'. Theranostics 10 (7) :3064-3082. |
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| Glezeva N; Moran B; Collier P; Moravec C; Phelan D; Donnellan E; Russell-Hallinan A; O'connor D; Gallagher W; Gallagher J (2019) '3069Epigenetic changes in heart failure cohorts: novel insights into methylation changes of protein and RNA coding genes in human cardiac tissue'. European Heart Journal 40 (Supplement_1) |
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| Guttà C; Rahman A; Aura C; Dynoodt P; Charles EM; Hirschenhahn E; Joseph J; Wouters J; de Chaumont C; Rafferty M (2020) 'Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma'. Cell Death and Disease 11 (2) |
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| Kearns C; Feighery R; Caffrey JM; Higgins M; Smith M; Murphy V; O’reilly S; Horgan AM; Walshe J; McDermott R (2020) 'Understanding and attitudes toward cancer clinical trials among patients with a cancer diagnosis: National study through cancer trials Ireland'. Cancers 12 (7) :1-26. |
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| Mazo C; Barron S; Mooney C; Gallagher WM (2019) 'Multi-gene prognostic signatures and prediction of pathological complete response of ER-Positive HER2-negative breast cancer patients to neo-adjuvant chemotherapy'. Annals of Oncology 30 :v86-v86. |
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| Mazo C; Barron S; Mooney C; Gallagher WM (2020) 'Multi-gene prognostic signatures and prediction of pathological complete response to neoadjuvant chemotherapy in er-positive, her2-negative breast cancer patients'. Cancers 12 (5) |
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| Mazo C; Kearns C; Mooney C; Gallagher WM (2020) 'Clinical decision support systems in breast cancer: A systematic review'. Cancers 12 (2) |
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| Miller IS; Shiels LP; Conroy E; Connor K; Dicker P; Gallagher WM; Donovan NO; Kerbel RS; Crown J; Byrne AT (2019) 'Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents'. Scientific Reports 9 (1) |
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| Rahman A; Jahangir C; Lynch SM; Alattar N; Aura C; Russell N; Lanigan F; Gallagher WM (2020) 'Advances in tissue-based imaging: impact on oncology research and clinical practice'. Expert Review of Molecular Diagnostics |
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| Silva R; Moran B; Russell NM; Fahey C; Vlajnic T; Manecksha RP; Finn SP; Brennan DJ; Gallagher WM; Perry AS (2020) 'Evaluating liquid biopsies for methylomic profiling of prostate cancer'. Epigenetics 15 (44018) :715-727. |
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| Vandamme N; Denecker G; Bruneel K; Blancke G; Akay Ö; Taminau J; De Coninck J; De Smedt E; Skrypek N; Van Loocke W (2020) 'The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype'. Cancer research 80 (14) :2983-2995. |
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| Walsh L; Haley KE; Moran B; Mooney B; Tarrant F; Madden SF; Di Grande A; Fan Y; Das S; Rueda OM (2019) 'BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer'. Clinical cancer research : an official journal of the American Association for Cancer Research 25 (23) :7139-7150. |
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| Dr Antonio Garzon Vico | |
| Garzón-Vico A; Rosier J; Gibbons P; McNamara P (2020) 'The Impact of Failure and Success Experience on Drug Development'. Journal of Product Innovation Management 37 (1) :74-96. |
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| Assoc Professor Carmel Hensey | |
| Stancheva I; Hensey C; Meehan RR (2019) 'Erratum to: Loss of the maintenance methyltransferase, xDnmt1, induces apoptosis in Xenopus embryos (The EMBO Journal, (2001), 20, 8, (1963-1973), 10.1093/emboj/20.8.1963)'. EMBO Journal 38 (20) |
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| Dr Chandralal Hewage | |
| Timmons PB; O'Flynn D; Conlon JM; Hewage CM (2019) 'Structural and positional studies of the antimicrobial peptide brevinin-1BYa in membrane-mimetic environments'. Journal of Peptide Science 25 (11) |
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| Timmons PB; O’Flynn D; Conlon JM; Hewage CM (2019) 'Insights into conformation and membrane interactions of the acyclic and dicarba-bridged brevinin-1BYa antimicrobial peptides'. European Biophysics Journal 48 (8) :701-710. |
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| Dr David Hughes | |
| Butt J; Jenab M; Pawlita M; Overvad K; Tjonneland A; Olsen A; Boutron-Ruault MC; Carbonnel F; Mancini FR; Kaaks R (2019) 'Antibody responses to Fusobacterium nucleatum Proteins in prediagnostic blood samples are not associated with risk of developing colorectal cancer'. Cancer Epidemiology Biomarkers and Prevention 28 (9) :1552-1555. |
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| Butt J; Jenab M; Pawlita M; Tjønneland A; Kyrø C; Boutron-Ruault MC; Carbonnel F; Dong C; Kaaks R; Kühn T (2020) 'Antibody Responses to Helicobacter pylori and Risk of Developing Colorectal Cancer in a European Cohort'. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 29 (7) :1475-1481. |
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| Kunzmann AT; Proença MA; Jordao HW; Jiraskova K; Schneiderova M; Levy M; Liska V; Buchler T; Vodickova L; Vymetalkova V (2019) 'Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients'. European Journal of Clinical Microbiology and Infectious Diseases 38 (10) :1891-1899. |
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| Méplan C; Hughes DJ (2020) 'The role of selenium in health and disease: Emerging and recurring trends'. Nutrients 12 (4) |
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| Murphy N; Moreno V; Hughes DJ; Vodicka L; Vodicka P; Aglago EK; Gunter MJ; Jenab M (2019) 'Lifestyle and dietary environmental factors in colorectal cancer susceptibility'. Molecular Aspects of Medicine 69 :2-9. |
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| Outzen M; Tjønneland A; Hughes DJ; Jenab M; Frederiksen K; Schomburg L; Morris S; Overvad K; Olsen A (2020) 'Toenail selenium, plasma selenoprotein P and risk of advanced prostate cancer: A nested case-control study'. International Journal of Cancer |
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| Scott AJ; Alexander JL; Merrifield CA; Cunningham D; Jobin C; Brown R; Alverdy J; O'Keefe SJ; Gaskins HR; Teare J (2019) 'International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis'. Gut 68 (9) :1624-1632. |
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| Vymetalkova V; Rosa F; Susova S; Bendova P; Levy M; Buchler T; Kral J; Bartu L; Vodickova L; Hughes DJ (2020) 'Expression quantitative trait loci in ABC transporters are associated with survival in 5-FU treated colorectal cancer patients'. Mutagenesis 35 (3) :273-281. |
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| Dr Andrew Irving | |
| Foster JR; Ueno S; Chen MX; Harvey J; Dowell SJ; Irving AJ; Brown AJ (2019) 'N-Palmitoylglycine and other N-acylamides activate the lipid receptor G2A/GPR132'. Pharmacology Research and Perspectives 7 (6) |
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| Dr Cathriona Kearns | |
| Kearns C; Feighery R; Caffrey JM; Higgins M; Smith M; Murphy V; O’reilly S; Horgan AM; Walshe J; McDermott R (2020) 'Understanding and attitudes toward cancer clinical trials among patients with a cancer diagnosis: National study through cancer trials Ireland'. Cancers 12 (7) :1-26. |
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| Mazo C; Kearns C; Mooney C; Gallagher WM (2020) 'Clinical decision support systems in breast cancer: A systematic review'. Cancers 12 (2) |
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| Professor Breandán Kennedy | |
| Akella JS; Carter SP; Nguyen K; Tsiropoulou S; Moran AL; Silva M; Rizvi F; Kennedy BN; Hall DH; Barr MM (2020) 'Ciliary rab28 and the BBSome negatively regulate extracellular vesicle shedding'. eLife 9 |
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| Carter SP; Moran AL; Matallanas D; McManus GJ; Blacque OE; Kennedy BN (2020) 'Genetic Deletion of Zebrafish Rab28 Causes Defective Outer Segment Shedding, but Not Retinal Degeneration'. Frontiers in Cell and Developmental Biology 8 |
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| Merrigan SL; Park B; Ali Z; Jensen LD; Corson TW; Kennedy BN (2020) 'Calcitriol and non-calcemic Vitamin D analogue, 22-oxacalcitriol, attenuate developmental and pathological choroidal vasculature angiogenesis ex vivo and in vivo'. Oncotarget 11 (5) :493-509. | |
| Merrigan SL; Park B; Ali Z; Jensen LD; Corson TW; Kennedy BN (2020) 'Calcitriol and non-calcemic vitamin D analogue, 22-oxacalcitriol, attenuate developmental and pathological choroidal vasculature angiogenesis ex vivo and in vivo.'. Oncotarget 11 (5) :493-509. |
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| Obaidi I; Cassidy H; Gaspar VI; McCaul J; Higgins M; Halász M; Reynolds AL; Kennedy BN; McMorrow T (2020) 'Curcumin sensitizes kidney cancer cells to TRAIL-induced apoptosis via ROS mediated activation of JNK-CHOP pathway and upregulation of DR4'. Biology 9 (5) |
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| Slater K; Heeran A; Sanz-Pamplona R; Kalirai H; Rahman A; Helmi M; Garcia-Mulero S; O’Connell F; Bosch R; Portela A (2020) 'High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells'. |
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| Sundaramurthi H; Roche SL; Grice GL; Moran A; Dillion ET; Campiani G; Nathan JA; Kennedy BN (2020) 'Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness'. Frontiers in Cell and Developmental Biology 8 |
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| Wade SM; Ohnesorge N; McLoughlin H; Biniecka M; Carter SP; Trenkman M; Cunningham CC; McGarry T; Canavan M; Kennedy BN (2019) 'Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis'. EBioMedicine 47 :402-413. |
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| Ward R; Ali Z; Slater K; Reynolds AL; Jensen LD; Kennedy BN (2020) 'Pharmacological restoration of visual function in a zebrafish model of von-Hippel Lindau disease'. Developmental Biology 457 (2) :226-234. |
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| Ward R; Kaylor J; Cobice D; Pepe D; McGarrigle E; Brockerhoff S; Hurley J; Travis G; Kennedy B (2020) 'Non-photopic and photopic visual cycles differentially regulate immediate, early and late-phases of cone photoreceptor-mediated vision'. |
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| Ward R; Kaylor JJ; Cobice DF; Pepe DA; McGarrigle EM; Brockerhoff SE; Hurley JB; Travis XGH; Kennedy XBN (2020) 'Non-photopic and photopic visual cycles differentially regulate immediate, early, and late phases of cone photoreceptor-mediated vision'. Journal of Biological Chemistry 295 (19) :6482-6497. |
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| Professor Therese Kinsella | |
| Mulvaney EP; O'Sullivan ÁG; Eivers SB; Reid HM; Kinsella BT (2019) 'Differential expression of the TPα and TPβ isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TPβ during monocyte-macrophage differentiation'. Experimental and Molecular Pathology 110 |
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| Dr Stefanie Kuhns | |
| Kuhns S; Seixas C; Pestana S; Tavares B; Nogueira R; Jacinto R; Ramalho JS; Simpson JC; Andersen JS; Echard A (2019) 'Rab35 controls cilium length, function and membrane composition'. EMBO Reports 20 (10) |
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| Dr Seodhna Lynch | |
| Lynch SM; Ward M; McNulty H; Angel CZ; Horigan G; Strain JJ; Purvis J; Tackett M; McKenna DJ (2020) 'Serum levels of miR-199a-5p correlates with blood pressure in premature cardiovascular disease patients homozygous for the MTHFR 677C > T polymorphism'. Genomics 112 (1) :669-676. |
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| Professor Patricia Maguire | |
| Haire G; Egan K; Parmar K; McKinnon T; Monteith C; O'Connor H; Kevane B; Maguire P; Szklanna PB; Galligan M (2019) 'Alterations in fibrin formation and fibrinolysis in early onset-preeclampsia: Association with disease severity'. European Journal of Obstetrics and Gynecology and Reproductive Biology 241 :19-23. |
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| Kacprzyk J; Parsons M; Maguire PB; Stewart GS (2019) 'Examining gender effects in different types of undergraduate science assessment'. Irish Educational Studies 38 (4) :467-480. |
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| Assoc Professor Siobhán McClean | |
| Pither MD; McClean S; Silipo A; Molinaro A; Di Lorenzo F (2020) 'A chronic strain of the cystic fibrosis pathogen Pandoraea pulmonicola expresses a heterogenous hypo-acylated lipid A'. Glycoconjugate Journal |
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| Reece E; McClean S; Greally P; Renwick J (2019) 'The prevalence of Aspergillus fumigatus in early cystic fibrosis disease is underestimated by culture-based diagnostic methods'. Journal of Microbiological Methods 164 |
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| Assoc Professor Tara McMorrow | |
| Cassidy H; Slyne J; Higgins M; Radford R; Conlon PJ; Watson AJ; Ryan MP; McMorrow T; Slattery C (2019) 'Neutrophil gelatinase-associated lipocalin (NGAL) is localised to the primary cilium in renal tubular epithelial cells - A novel source of urinary biomarkers of renal injury'. Biochimica et Biophysica Acta - Molecular Basis of Disease 1865 (12) |
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| Islam MN; Griffin TP; Sander E; Rocks S; Qazi J; Cabral J; McCaul J; McMorrow T; Griffin MD (2019) 'Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers'. Stem Cell Research and Therapy 10 (1) |
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| Obaidi I; Cassidy H; Gaspar Ibanez V; McCaul J; Higgins M; McMorrow T (2020) 'Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4'. Biology Open |
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| Obaidi I; Cassidy H; Gaspar VI; McCaul J; Higgins M; Halász M; Reynolds AL; Kennedy BN; McMorrow T (2020) 'Curcumin sensitizes kidney cancer cells to TRAIL-induced apoptosis via ROS mediated activation of JNK-CHOP pathway and upregulation of DR4'. Biology 9 (5) |
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| Professor Wim Meijer | |
| Vázquez-Boland JA; Scortti M; Meijer WG (2020) 'Conservation of rhodococcus equi (Magnusson 1923) goodfellow and alderson 1977 and rejection of rhodococcus hoagii (morse 1912) kämpfer et al. 2014'. International Journal of Systematic and Evolutionary Microbiology 70 (5) :3572-3576. |
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| Dr Raul Miranda Caso Luengo | |
| Palmer-Brown W; Miranda-CasoLuengo R; Wolfe KH; Byrne KP; Murphy CD (2019) 'The CYPome of the model xenobiotic-biotransforming fungus Cunninghamella elegans'. Scientific Reports 9 (1) |
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| Professor Cormac Murphy | |
| Murphy C (2020) 'The role of microorganisms in the degradation of fluorinated xenobiotics in the environment'. Chimica Oggi 38 (3) :4-6. | |
| Palmer-Brown W; Miranda-CasoLuengo R; Wolfe KH; Byrne KP; Murphy CD (2019) 'The CYPome of the model xenobiotic-biotransforming fungus Cunninghamella elegans'. Scientific Reports 9 (1) |
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| Dr Tanja Narancic | |
| Blank LM; Narancic T; Mampel J; Tiso T; O'Connor K (2020) 'Biotechnological upcycling of plastic waste and other non-conventional feedstocks in a circular economy'. Current Opinion in Biotechnology 62 :212-219. |
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| Li WJ; Narancic T; Kenny ST; Niehoff PJ; O’Connor K; Blank LM; Wierckx N (2020) 'Unraveling 1,4-Butanediol Metabolism in Pseudomonas putida KT2440'. Frontiers in Microbiology 11 |
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| Narancic T; Cerrone F; Beagan N; O'Connor KE (2020) 'Recent advances in bioplastics: Application and biodegradation'. Polymers 12 (4) |
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| Ruiz C; Kenny ST; Narancic T; Babu R; Connor KO (2019) 'Conversion of waste cooking oil into medium chain polyhydroxyalkanoates in a high cell density fermentation'. Journal of Biotechnology 306 :9-15. |
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| Assoc Professor David O'Connell | |
| McGauran G; Linse S; O’Connell DJ (2020) 'Single step purification of glycogen synthase kinase isoforms from small scale transient expression in HEK293 cells with a calcium-dependent fragment complementation system'. 2095 :385-396. |
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| Synnott NC; O’Connell D; Crown J; Duffy MJ (2020) 'COTI-2 reactivates mutant p53 and inhibits growth of triple-negative breast cancer cells'. Breast Cancer Research and Treatment 179 (1) :47-56. |
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| Professor Kevin O'Connor | |
| Beagan N; O'Connor KE; Del Val IJ (2020) 'Model-based operational optimisation of a microbial bioprocess converting terephthalic acid to biomass'. Biochemical Engineering Journal 158 |
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| Blank LM; Narancic T; Mampel J; Tiso T; O'Connor K (2020) 'Biotechnological upcycling of plastic waste and other non-conventional feedstocks in a circular economy'. Current Opinion in Biotechnology 62 :212-219. |
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| Cerrone F; Pozner T; Siddiqui A; Ceppi P; Winner B; Rajendiran M; Babu R; Ibrahim HS; Rodriguez BJ; Winkler J (2020) 'Polyhydroxyphenylvalerate/polycaprolactone nanofibers improve the life-span and mechanoresponse of human IPSC-derived cortical neuronal cells'. Materials Science and Engineering C 111 |
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| Cerrone F; Radivojevic J; Nikodinovic-Runic J; Walsh M; Kenny ST; Babu R; O'Connor KE (2019) 'Novel sodium alkyl-1,3-disulfates, anionic biosurfactants produced from microbial polyesters'. Colloids and Surfaces B: Biointerfaces 182 |
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| Jaksic J; Ostojic S; Micic D; Tokic Vujosevic Z; Milovanovic J; Karkalic R; O'Connor KE; Kenny ST; Casey W; Nikodinovic-Runic J (2020) 'Thermal properties of 3-hydroxy fatty acids and their binary mixtures as phase change energy storage materials'. International Journal of Energy Research 44 (2) :1294-1302. |
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| Narancic T; Cerrone F; Beagan N; O'Connor KE (2020) 'Recent advances in bioplastics: Application and biodegradation'. Polymers 12 (4) |
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| RameshKumar S; Shaiju P; O'Connor KE; P RB (2020) 'Bio-based and biodegradable polymers - State-of-the-art, challenges and emerging trends'. Current Opinion in Green and Sustainable Chemistry 21 :75-81. |
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| Ruiz C; Kenny ST; Narancic T; Babu R; Connor KO (2019) 'Conversion of waste cooking oil into medium chain polyhydroxyalkanoates in a high cell density fermentation'. Journal of Biotechnology 306 :9-15. |
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| Dr Tadhg Ó'Cróinín | |
| Whelan MVX; Ardill L; Koide K; Nakajima C; Suzuki Y; Simpson JC; Ó Cróinín T (2019) 'Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni'. Scientific Reports 9 (1) |
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| Dr Niamh O'Sullivan | |
| Fowler PC; Garcia-Pardo ME; Simpson JC; O’Sullivan NC (2019) 'NeurodegenERation: The Central Role for ER Contacts in Neuronal Function and Axonopathy, Lessons From Hereditary Spastic Paraplegias and Related Diseases'. Frontiers in Neuroscience 13 |
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| Dr Jens Rauch | |
| Lee S; Rauch J; Kolch W (2020) 'Targeting MAPK signaling in cancer: Mechanisms of drug resistance and sensitivity'. International Journal of Molecular Sciences 21 (3) |
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| Dr Helen Reid | |
| Mulvaney EP; O'Sullivan ÁG; Eivers SB; Reid HM; Kinsella BT (2019) 'Differential expression of the TPα and TPβ isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TPβ during monocyte-macrophage differentiation'. Experimental and Molecular Pathology 110 |
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| Mulvaney EP; Reid HM; Bialesova L; Bouchard A; Salvail D; Kinsella BT (2020) 'NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension'. BMC Pulmonary Medicine 20 (1) |
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| Mulvaney EP; Reid HM; Bialesova L; Mendes-Ferreira P; Adão R; Brás-Silva C; Kinsella BT (2020) 'Efficacy of the thromboxane receptor antagonist NTP42 alone, or in combination with sildenafil, in the sugen/hypoxia-induced model of pulmonary arterial hypertension'. European Journal of Pharmacology |
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| Dr Emmanuel Reynaud | |
| Alruwaili M; Lopez JA; McCarthy K; Reynaud EG; Rodriguez BJ (2019) 'Liquid-phase 3D bioprinting of gelatin alginate hydrogels: influence of printing parameters on hydrogel line width and layer height'. Bio-Design and Manufacturing 2 (3) :172-180. |
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| Merces G; Kennedy C; Lenoci B; Reynaud E; Burke N; Pickering M (2020) 'The Incubot: A 3D Printer-Based Microscope for Long-Term Live Cell Imaging within a Tissue Culture Incubator'. |
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| Torres-Leguizamon M; Reynaud EG; Néfau T; Duplessy C (2020) 'HaRePo (harm reduction by post): An innovative and effective harm reduction programme for people who use drugs using email, telephone, and post service'. Harm Reduction Journal 17 (1) |
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| Dr Michelle Rich | |
| Rich MH; Sharrock AV; Ashoorzadeh A; Patterson AV; Smaill JB; Ackerley DF (2020) 'Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug.'. Biotechnology letters |
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| Williams EM; Rich MH; Mowday AM; Ashoorzadeh A; Copp JN; Guise CP; Anderson RF; Flanagan JU; Smaill JB; Patterson AV (2019) 'Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy.'. Biochemistry 58 (35) :3700-3710. |
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| Professor Jan Rosier | |
| Garzón-Vico A; Rosier J; Gibbons P; McNamara P (2020) 'The Impact of Failure and Success Experience on Drug Development'. Journal of Product Innovation Management 37 (1) :74-96. |
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| Dr Craig Slattery | |
| Cassidy H; Slyne J; Higgins M; Radford R; Conlon PJ; Watson AJ; Ryan MP; McMorrow T; Slattery C (2019) 'Neutrophil gelatinase-associated lipocalin (NGAL) is localised to the primary cilium in renal tubular epithelial cells - A novel source of urinary biomarkers of renal injury'. Biochimica et Biophysica Acta - Molecular Basis of Disease 1865 (12) |
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| Dr Dieter Waschbusch | |
| McGrath E; Waschbüsch D; Baker BM; Khan AR (2019) 'LRRK2 binds to the Rab32 subfamily in a GTP-dependent manner via its armadillo domain.'. Small GTPases :1-14. |
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| Dr Yan Yan | |
| Boselli L; Lopez H; Zhang W; Cai Q; Giannone VA; Li J; Moura A; de Araujo JM; Cookman J; Castagnola V (2020) 'Classification and biological identity of complex nano shapes'. Communications Materials 1 (1) |
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| Hudecz D; Khire T; Chung HL; Adumeau L; Glavin D; Luke E; Nielsen MS; Dawson KA; McGrath JL; Yan Y (2020) 'Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood-Brain Barrier Model'. ACS Nano 14 (1) :1111-1122. |
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| Murschhauser A; Röttgermann PJF; Woschée D; Ober MF; Yan Y; Dawson KA; Rädler JO (2019) 'A high-throughput microscopy method for single-cell analysis of event-time correlations in nanoparticle-induced cell death'. Communications Biology 2 (1) |
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Conference Publications
| Assoc Professor John Crean | |
| Crean J; Clerkin S; Treacy N; Davis J; Dodd T; Singh K; Wychowaniec J; Brougham D (2019) Growth and Differentiation of iPSC-Derived Kidney Organoids Using Fully Synthetic Peptide Hydrogels In: American Society for Cell Biology, Washington DC, USA | |
| Crean J; Davis J; Andrews D; Kennedy C; Dodd T; Hoban A; Moss C (2019) TGFβ signals to chromatin via a complexing interaction of Smad3 with the Polycomb Repressive Complex during the determination of renal epithelial fate In: American Society for Cell Biology, Washington DC, USA | |
| Crean J; Kennedy C; Andrews D; Davis J; Oliviero G; Cagney G (2019) Molecular Characterisation of an Epigenetic Regulatory Circuit Comprising Smad 3 and Ezh2 in an iPSC-Derived Model of Retinal Degeneration In: American Society for Cell Biology, Washington DC, USA | |
| Professor William Gallagher | |
| Collins DM; Browne A; Madden SF; Gaynor N; Kay EW; Fay J; Sheehan K; Toomey S; Eustace AJ; Gallagher WM (2020) Abstract P1-10-13: Examination of CCL26, CCL17 and CCL19 chemokines as biomarkers in HER2+ breast cancer (BC) in the neo-adjuvant setting In: Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas, |
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| Mazo C; Barron S; Mooney C; Gallagher WM (2019) Multi-gene prognostic signatures and prediction of pathological complete response of ER-Positive HER2-negative breast cancer patients to neo-adjuvant chemotherapy In: ANNALS OF ONCOLOGY, |
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| O'Connor DP; Walsh L; Haley K; Moran B; Mooney B; Madden S; Das S; Rueda O; Dowling C; Vareslija D (2020) Abstract P3-10-06: Combination of BET and FGFR inhibition as a rational therapeutic strategy for invasive lobular breast cancer In: Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas, |
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| Dr David Hughes | |
| Genua F; Raghunatan V; Mathews K; Hegoburu A; Gallagher W; Hughes D (2020) Association of circulating soluble CD14, iFABP and Zonulin levels with stages of colorectal neoplasia In: Irish Association of Cancer Research annual meeting, Galway, Ireland | |
| Hughes DJ (2019) Selenium status, selenoprotein gene variation and cancer risk (keynote invited seminar) In: 6th International Conference on Selenium in the Environment and Human Health (ICSEHH), Xi’an, China | |
| Hughes DJ; Fedirko V; Schomburg L; Hybsier S; Méplan C (2020) Association of selenium status and selenoprotein genetic variations with cancer risk In: Selenium Research for Environment and Human Health: Perspectives, Technologies and Advancements - Proceedings of the 6th International Conference on Selenium in the Environment and Human Health, 2019, |
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| Mandle H; Fedirko V; Jenab M; Hughes D; Gunter M; Riboli E (2020) Inflammation and gut barrier function-related genes and survival from colorectal cancer in western European populations In: American Association of Cancer Research (AACR) annual meeting (virtual),, virtual | |
| Manguy J; Vodicka P; Vymetalkova V; Levy M; Liska V; Swan N; Hughes D (2019) Association of selenoprotein gene variations with colorectal cancer risk. In: UCD Molecular and Computational Biology Symposium 2019, Dublin, Ireland | |
| Assoc Professor Siobhán McClean | |
| (2019) Program & Papers In: Pediatric Pulmonology, |
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| Dr Tadhg Ó'Cróinín | |
| Alshehri H; Clyne M; O Croinin T (2019) Genomic and Phenotypic analysis of freshly isolated strains of Campylobacter jejuni In: CHRO (Campylobacter and Helicobacter Related Organisms, | |
| Carney G; Clyne M; Ó'Cróinín T (2019) Investigating the link between Fluoroquinolone Resistance, Survival and Virulence in freshly isolated Campylobacter jejuni strains In: CHRO (Campylobacter Helicobacter and Related Organisms), Belfast | |
| Whelan M; Ardill L; Koide K; Nakajima C; Suzuki Y; Simpson J; Ó'Cróinín T (2019) Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni In: CHRO (Campylobacter and Helicobacter related Organisms), | |
| Assoc Professor Tara McMorrow | |
| Food Safety Authority of Ireland (2020) FSAI Risk management options related to the use of botanicals in food supplements. Food Safety Authority of Ireland: Food Safety Authority of Ireland | |
| Dr David Hughes | |
| Hughes D (2020) Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort. | |