Investigation of novel therapeutic strategies for Alzheimer’s disease-related

Supervisor: Dr Derek Costello

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder, characterised by aberrant neuronal dysfunction and progressive cognitive decline. The vast majority of AD cases are late-onset and sporadic, although conditions such as metabolic dysfunction, cardiovascular disease and environmental factors are known to promote risk. There is currently no cure, and treatment options are limited.

Chronic inflammation underlies the pathology associated with most neurodegenerative conditions, including age and AD. The primary objectives of this project are (i) to examine the cellular mechanisms associated with inflammatory conditions, and investigate how these might promote AD pathology, and (ii) evaluate novel therapeutic strategies to alleviate the inflammation and brain dysfunction associated with AD. This multidisciplinary and collaborative study will involve in vitro electrophysiology, behavioural analysis, cell culture and a range of biochemical techniques.

The successful candidate will be enrolled in a 4-year structured PhD programme based in the UCD Conway Institute, will receive a stipend of €16,000 p.a. and full EU tuition fees.

Requirements: Applicants should have, or expect to achieve, a minimum of upper 2nd class honours degree (or equivalent) in Neuroscience, Pharmacology, Physiology or related life science discipline. Research experience using animal models, electrophysiology and/or behavioural analysis is encouraged but not essential.

Apply: Applications should contain a 1-page cover letter outlining your interest and suitability for the position, a detailed CV and contact information for 2 referees. Applications should be received by email to, no later than June 16th 2019. Informal inquiries may be made to Derek Costello prior to the application deadline.