Bond Group

Childhood and Adolescent Leukaemia

Group Members

Jonathan Bond
Group Leader
Maud Gilligan
M.Sc. Student, Bond Group
Luke Jones
Postdoctoral Researcher, Bond Group
Thomas Lefeivre
Ph.D. Student, Bond/Ryan Groups
Peter McCarthy
Clinical Research Fellow, Bond Group
Cosmin Tudose
Ph.D. Student, Bond/Ryan Groups

About the Group

What we do 

Decades of scientific and clinical research have enabled enormous advances in the treatment of children and adolescents with leukaemia, but there is still much room for improvement.

To progress further, we need a better understanding of the molecular processes that underpin leukaemia biology.  The genomic age has seen an explosion in our knowledge of the genetic and epigenetic landscape of paediatric leukaemia, but analysis of these complex data is challenging, and requires interdisciplinary collaboration between clinicians, biologists and computational experts. To achieve this, our research programme is co-located at SBI and at the Irish National Paediatric Haematology Oncology clinical service at Children’s Health Ireland.

Working together, we use systems biology approaches to tackle the key questions in childhood and adolescent leukaemia. In particular, we are interested in working out how disruptions of epigenetic and transcriptional programmes alter leukaemia biology.

Work with us 

PhD and post-doctoral positions are advertised on the SBI website and elsewhere, including social media channels. We are also interested in supporting independent funding applications by Irish and international candidates. For all enquiries, please contact Jonathan Bond by e-mail. 

 

For a full list of publications see https://people.ucd.ie/jonathan.bond/publications.

Recent Key Publications

Bond, J., Krzywon, A., Lhermitte, L., Roumier, C., Roggy, A., Belhocine, M., Kheirallah, A.K., Villarese, P., Hypolite, G., Garnache-Ottou, F., et al. (2019). A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis. bioRxiv, 2019.2012.2010.870121.

Cordonnier G, Mandoli A, Cagnard N, Hypolite G, Lhermitte L, Verhoeyen E, Asnafi V, Dillon N, Macintyre E, Martens J, Bond J. CBFβ-SMMHC affects genome-wide Polycomb Repressive Complex 1 activity in Acute Myeloid Leukemia. Cell Reports 2020; 30, 299–307.

Jones L, McCarthy P, Bond J. Epigenetics of paediatric acute myeloid leukaemia. British Journal of Haematology. 2020;188(1):63-76. 

Bond J, Touzart A, Lepretre S, Graux C, Bargetzi M, Lhermitte L, Hypolite G, Leguay T, Hicheri Y, Guillerm G, Bilger K, Lheritier V, Hunault M, Huguet F, Chalandon Y, Ifrah N, Macintyre E, Dombret H, Asnafi V, Boissel N. DNMT3A mutation is associated with increased age and adverse outcome in adult T-acute lymphoblastic leukemia. Haematologica 2019 Aug;104(8):1617-1625

Yi G, Mandoli A, Jussen L, Tijchon E, van Bergen MGJM, Cordonnier G, Hansen M, Kim B, Nguyen LN, Jansen PWTC, Vermeulen M, van der Reijden B, van den Akker E, Bond J, Martens JHA. CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1. Blood Cancer Journal 2019 Mar 8;9(3):33.

Bond J, Labis E, Marceau-Renaut A, Duployez N, Labopin M, Hypolite G, Michel G, Ducassou S, Boutroux H, Nelken B, Bertrand Y, Baruchel A, Petit A, Asnafi V, Leverger G, Preudhomme C, Macintyre E, Lapillonne H. Polycomb Repressive Complex 2 haploinsufficiency identifies a high-risk subgroup of pediatric acute myeloid leukemia. Leukemia 2018 Aug;32(8):1878-1882.

Bond J, Graux C, Lhermitte L, Lara D, Cluzeau T, Leguay T, Cieslak A, Trinquand A, Pastoret C, Belhocine M, Spicuglia S, Lheritier V, Leprêtre S, Thomas X, Huguet F, Ifrah N, Dombret H, Macintyre E, Boissel N, Asnafi V. Early response-based therapy stratification improves survival in adult ETP-ALL: a GRAALL study. Journal of Clinical Oncology 2017 Aug 10;35(23):2683-2691.

Cordonnier G, Mandoli A, Radhouane A, Hypolite G, LhermitteL, Belhocine M, Asnafi V, Macintyre E, Martens J, Fumagalli S, Bond J. CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis. Leukemia 2017 Jun;31(6):1443-1446.

 

Links

https://twitter.com/jbond2019

https://www.irishexaminer.com/breakingnews/lifestyle/features/blood-sweat-and-tears-to-survive-cancer-839253.html

https://www.irishexaminer.com/breakingnews/ireland/we-dont-have-enough-funds-to-support-them--irish-cancer-society-cant-afford-life-saving-research-904750.html

https://www.irishexaminer.com/breakingnews/lifestyle/healthandlife/finding-the-cure-immunotherapy-offers-hope-to-children-battling-cancer-920302.html

 

SBI blog posts

Notes on a Pandemic from a Clinician Scientist - 17 July 2020

A Drug by Any Other Name - 19 December 2019 

The French Connection at SBI: A Bastille Day Special - 12 July 2019 

New Prognostic Marker in Childhood and Adolescent Leukaemia - 17 July 2018 

Leukaemia Researcher Jonathan Bond Joins SBI as UCD 'Brendan McGonnell' Professor of Paediatric Molecular Haemato-Oncology - 5 April 2018 

 

 

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