Group Members

Walter Kolch
Director, Group Leader
Donagh Egan
Ph.D. Student, Kolch/Brennan Groups
Luis Iglesias Martinez
Postdoctoral Researcher, Kolch Group
Martina Kreileder
P.h.D. Student, Kolch Group
Aleksandar Krstic
Postdoctoral Researcher, Kolch Group

About the Group

What We Do

The Kolch group is internationally recognised for its cutting-edge research using systems approaches to understand signalling networks. The group uses computational modelling, translational medicine and omics approaches to analyse biological networks with the goal of elucidating the molecular and cellular mechanisms of diseases such as cancer and inflammation (hidradenitis suppurativa, psoriasis, rheumatoid arthritis). The group is also focused on designing new approaches to personalised diagnostics and treatment of diseases based on systems level and molecular mechanistic understanding. 

Key Research Highlights 

  • Pioneered the use of dominant negative mutants to map signalling pathways in mammalian cells 
  • Development of biochemical high throughput and cellular drug screening assays crucial for the development of two widely used and highly specific PKC inhibitors, Goe6976 and Goe6815
  • Discovered mechanisms of crosstalk between protein kinase C and Raf pathways 
  • Co-discovered the crosstalk between the cAMP and Raf-1 signalling pathways


Recent Publications

An Integrated Global Analysis of Compartmentalized HRAS Signaling. Santra T, Herrero A, Rodriguez J, von Kriegsheim A, Iglesias-Martinez LF, Schwarzl T, Higgins D, Aye TT, Heck AJR, Calvo F, Agudo-Ibáñez L, Crespo P5, Matallanas D, Kolch W. Cell Rep (2019); 12;26(11):3100-3115.

Identification of a MYCN and Wnt-related VANGL2-ITLN1 fusion gene in neuroblastoma. Duffy D, Konietzny A, Krstic A, Prakash Mehta J, Halasz M, Kolch K. Gene Reports (2018); 12: 187-200.

From oncogenic mutation to dynamic code. Kolch K, Kiel C. Science (2018); 361(6405): 844-845.

 

See Also: 

Precision Oncology Ireland

COLOSSUS

BREAST-PREDICT

TOPMed10

TOP