My doctoral research focused on identifying novel mechanisms underpinning the regulation of glucose metabolism in oxygen-deprived or ‘hypoxic’ human intestinal epithelial cells. Using various laboratory-based techniques, we identified that hypoxia alters the spatial organisation of the glycolytic pathway within cells to promote the formation of a hypoxia-sensitive enzymatic complex. Our team are now investigating if this complex may facilitate metabolic adaption to hypoxic stress as this may have significant implications for highly glycolytic cells, such as epithelial, immune and tumour cells.
A particular highlight for me was the numerous opportunities I had to showcase my research both nationally and internationally, thanks to my supervisor Prof. Cormac Taylor. These opportunities have been invaluable for forming important connections within our field of research and in aiding my own professional development. The friendships I formed during time as a PhD student were also a significant highlight for me. These connections not only enhanced my academic journey but created memories that I will hold onto long after graduating!
If you’re contemplating pursuing a PhD my main advice is to make sure you understand why you want to do a PhD and to make sure the topic you select is one which genuinely interests you. The path to becoming an independent researcher can be demanding and challenging at times. Having a genuine interest in your chosen research area is so important as it will be a great source of motivation during these tougher times. Additionally, I think it is crucial to surround yourself with a supportive network of friends, family, peers and mentors. Pursuing a PhD is immensely rewarding, but it does come with its own challenges. Building a support system of those who can offer encouragement and guidance when needed is key!
I was fortunate to carry out my research in Conway Institute of Biomolecular and Biomedical Research on UCD’s Belfield campus. I benefited greatly from the close collaboration among fellow researchers within the open-plan, shared laboratory environment, which is not commonly found in other universities. UCD strongly encourages collaboration with researchers from both internally and externally. These collaborations really help bring important expertise and resources together to address research questions more effectively. Collaborations I formed throughout my PhD in UCD have been a huge help to me as I continue to navigate continuing my research career.
View Sarah Kiernan's profile here.