Small Animal Clinical Studies
Faculty of Veterinary Science
University College Dublin
Ballsbridge, Co. Dublin 4 IRELAND
Our lab in involved in understanding the genetic basis for diseases in dog and cats. To do this, we have started a multi-year project documenting variations in the genetic DNA code for various breeds of dog and cat. It is our hope that these variations will allow us to undersatnd the basis for certain diseases.
DNA Markers
Not all of the genetic DNA code is suitable for disease studies. We require areas that show variation between individuals and within breeds. These give the power necessary to detect disease causing variations.
A measure of the variation at a particular region of the DNA is called the Polymorphism Information Content (=PIC). A value of over 70% suggests that a particular region of DNA is useful for further study.
Parentage / Paternity Testing
The markers detected above can be used in cases of disputed parentage or paternity. This is due to the father and mother passing on particular variations in the DNA to their offspring, which can be detected by DNA testing.
Origins of the Dog
Examination of the numerous breeds of dog and cat will allow for an understanding of the origins of the dog. Much of this information is unknown due to poor record keeping prior to the late 1800's.
Disease Markers
The ability to detect animals at increased risk for disease is important
for preventative breeding schemes and to allow for early treatment. This
is an important aim of our research and will benefit breeders and veterinarians
alike.