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Page last updated: August 2025

This section provides information on the research currently being conducted or facilitated by the UCD Cancer Trials Cluster. Radiotherapy Trials are conducted at St Luke’s Radiation Oncology Network (SLRON) and managed through our partners at the Irish Research Radiation Oncology Group. 

To learn more about clinical trial processes, see our 'What is Clinical Research' and our 'FAQs' pages. 

If you are interested in finding out more about the trials on offer, you can consult the associated link for each trial below. We strongly recommend that you discuss any potential study opportunity with your oncology or haematology medical team. For most of the studies below, we accept referrals nationally.

Enrollment on studies must be made through referrals by your oncology medical team.

Please contact (opens in a new window)cancertrials@ucd.ie with queries. 

Key terms used below:

Allied Health & Supportive Care Trial

A study in which a non-drug intervention is provided, usually to improve a person's quality of life

Medicinal Trial

Clinical trial for the investigation of a new medical product, including drugs, gene therapy, immunotherapy, or anaesthetics.

MMUH

The Mater Misericordiae University Hospital

MPH

The Mater Private Hospital
Observational Study Research that collects data through observation, including surveys, interviews, prospective, patient registries, etc. For observational studies, there is no intervention component.  

Placebo

A placebo is an inactive treatment that looks and feels like a real one. It has no active ingredients that can change your health. It’s used in some research studies to compare it with the real treatment and see which one works better. Placebos help researchers know if the real treatment is effective or not.

Radiotherapy Trial

A radiotherapy trial is a clinical study designed to investigate different aspects of radiotherapy treatment, such as the dose, its effectiveness in combination with other treatment types (such as surgery), new technologies, or exploring side effects. Radiotherapy trials are conducted in collaboration with the Irish Research Radiation Oncology Group (IRROG).

SVUH

St Vincent's University Hospital

Translational Study

A research study based in a lab that explores the mechanisms of a disease. This type of research is important in developing better treatments and understanding of the disease. 

Open Studies

Basket studies are research studies/trial that include multiple different cancer types. The current portfolio of UCD Cancer Trials Cluster basket studies are detailed below:

Name Purpose For People with Our location More Info Study Type Status
ASTER ANT 007 Compare abelacimab against apixaban for  venous thromboembolism recurrence and bleeding Cancer related venous thromboembolism receiving cancer treatment currently or in past six months. MMUH (opens in a new window)Click here Medicinal trial Open
RS18-032 (DENIS COLLINS BLOOD STUDY) Pre-clinical study on the combination of immune checkpoint inhibitors and monoclonal antibody therapies NA SVUH NA Translational Study Open
SWAN (Sleep Well at Night) A multi-faceted intervention to address sleep difficulties.  People with advanced cancer. SVUH Click here Observational Study Open
TPAC (Taste Changes/Dry Mouth) An investigation into taste problems associated with xerostomia (dry mouth) in patients with advanced cancer. Any locally advanced or metastatic cancer with taste problems. SVUH NA Observational Study Open
WAYFIND-R Understand the natural history of solid tumour cancers  People profiled with a next generation sequencing test. SVUH (opens in a new window)Click here Observational Study Open
CORreCT Cognition in Older adults Receiving systemic anti-Cancer Therapy Person age 65+ newly commencing immune checkpoint inhibitors. SVUH NA Observational Study Open
IDEATE – DS7300-203  A phase 2 pan-tumour, open label study to evaluate the efficacy and safety of Ifinatamab deruxtecan (I-DXd)  People with recurrent or metastatic solid tumours. SVUH (opens in a new window)Click here  Medicinal trial Open
19-21 SABR COMET 3 To compare the effect of Stereotactic Ablative Radiotherapy (SABR), relative to standard of care (SOC) alone, on overall survival, progression-free survival, toxicity, and quality of life. Patients with a histologically confirmed malignancy with metastatic disease detected on imaging. SVUH via via St Luke’s Radiation Oncology Network (opens in a new window)Click here Radiotherapy Trial Open

For details of all basket studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Breast cancer studies are research studies/trial targeted towards breast cancers, such as invasive lobular breast cancer, triple negative breast cancer, or HER2 positive breast cancer. The current portfolio of UCD Cancer Trials Cluster breast studies are detailed below:

Name Purpose For People with Our location(s) More Info Study Type Status
CAMBRIA-2 To compare the effectiveness and safety of camizestrant (AZD9833), a new oral medication that targets estrogen receptors, with standard hormone therapies. Early-stage breast cancer that is hormone receptor-positive and HER2-negative, and who have a higher risk of cancer returning.

MMUH & MPH & SVUH 

 (opens in a new window)Click here Medicinal Trial Open
Destiny 15 Evaluate the effectiveness of Trastuzumab Deruxtecan (T-DXd) in delaying disease progression.  People with HER2-low or HER2 Immunohistochemistry (IHC) 0 breast cancer, whose disease is untreatable by surgery or is metastatic. 

SVUH

 (opens in a new window)Click here Medicinal Trial

Open
EXPERT

Evaluate whether women who are at low risk (determined from genetic testing) can safely avoid post-surgery radiotherapy. 

 Female patients aged ≥50 years with HR-positive and HER2-negative early stage breast cancer. SVUH & MMUH via St Luke’s Radiation Oncology Network (opens in a new window)Click here Radiotherapy Trial Open 
FourLight-3 (C4391024)

To compare the effectiveness of: A) PF-07220060 plus Letrozole, against b) CDK4/6 inhibitor plus Letrozole 

 Hormone receptor (HR)-positive, HER2-negative advanced/metastatic breast cancer who have not received any  prior systemic anti-cancer treatment for advanced/metastatic disease SVUH & MMUH & MPH (opens in a new window)Click here Medicinal Trial Open
Treat ctDNA

Elacestrant for treating ER+/HER2- 

 Breast cancer patients with ctDNA relapse  MMUH & MPH (opens in a new window)Click here Medicinal trial Open
J2J-MC-JZLH  (Ember 4)  Study of adjuvant Imlunestrant vs standard adjuvant endocrine therapy  Previously received 2 to 5 years of adjuvant endocrine therapy for ER+, HER2- early breast cancer with an increased risk of recurrence SVUH (opens in a new window)Click here Medicinal Trial Open
MK-2870-010  To compare the effectiveness of the drug MK-2870 (alone or combined with Pembrolizumab) against standard treatment of physician’s choice. People with HR+/HER2-  advanced or metastatic breast cancer, which cannot be removed with surgery.  SVUH & MMUH (opens in a new window)Click here Medicinal Trial

Open
Merck MK-2870-012 To compare the efficacy and safety of a) adjuvant MK-2870 plus Pembrolizumab against b) treatment of physician’s choice. People with Triple-Negative Breast Cancer who received neoadjuvant therapy that was not fully effective.   SVUH (opens in a new window)Click here Medicinal Trial Open
Ovarian Escape To determine how common is 'ovarian escape' in women receiving ovarian function suppression Premenopausal women receiving ovarian function suppression and endocrine therapy for early-stage and metastatic hormone receptor- positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer SVUH & MMUH NA Translational study Open
Shamrock To examine the effectiveness of the drug trastuzumab deruxtecan (T-DXd)  People with HER2-positive breast cancer (stage 2 or 3) SVUH (opens in a new window)Click here Medicinal Trial On hold
SIGNATURE Study (RS21 036) To explore the potential use of exosomes, isolated from the blood of patients diagnosed with TNBC (triple negative breast cancer), as a personal biomarker for the individual. People with triple negative breast cancer SVUH NA Translational Study Open
ASCENT 05 A Randomized, Open-label, Phase 3 Study of Adjuvant Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician’s Choice.  Patients with Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy MMUH TBD Medicinal Trial Open
TAORMINA To investigate if the addition of stereotactic ablative radiotherapy (SABR) to the oligometastatic sites in addition to the standard first-line treatment can improve progression-free survival (PFS). Patients with oligometastatic breast cancer (OMBC) that will be allocated to combined stereotactic ablative radiotherapy (SABR) + systemic therapy  SVUH via via St Luke’s Radiation Oncology Network  (opens in a new window)Click here  Radiotherapy Trial Open
ATNEC To assess if omitting further axillary treatment (ALND and ART) is non-inferior to axillary treatment in terms of disease free survival (DFS) and results in reduced risk of lymphoedema at 5 years. Patients with early stage breast cancer and axillary nodal metastases on needle biopsy SVUH via via St Luke’s Radiation Oncology Network  (opens in a new window)Click here Radiotherapy Trial Opening Soon
FLAMINGO–01 To Evaluate the Efficacy and Safety of HER2/neu Peptide GLSI-100 (GP2 + GM-CSF). Patients with HER2/neu Positive with Residual Disease or High-Risk PCR after both Neoadjuvant and Postoperative Adjuvant Trastuzumab-based Therapy.  SVUH  TBD Medicinal Trial Opening Soon

For details of all breast cancer studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Central nervous system studies address cancers of the brain and spinal cord. The UCD Cancer Trials Cluster does not currently conduct studies of central nervous system cancers. However, please refer to our list of 'basket studies' which may be relevant. 

For details of all central nervous system studies available in Ireland, please refer to (opens in a new window)Cancer Trials Ireland. 

Gastrointestinal studies are research studies/trial of cancers located in the digestive system, such as the oesaphagus, liver, pancreas, stomach, intestine, bowel, rectum, and anus.

The current portfolio of UCD Cancer Trials Cluster gastrointestinal studies are detailed below:

Name Purpose For People with Our location(s) More Info Study Type Status
DP-IMRT (CTRIAL-IE 17-12) An early phase trial (Phase I/ II) to determine the appropriate dosage of radiotherapy. Resectable or borderline resectable pancreatic adenocarcinoma SVUH (opens in a new window)Click here Radiotherapy Trial  Open
FEED (CTI 20-26) Evaluate a 12-week nutritional care package consisting of diet, supplements, daily step target and dietitian and physiotherapist appointments.  People undergoing standard chemotherapy for pancreatic cancer SVUH (opens in a new window)Click here Allied Health & Supportive Care Trial Open
Mountaineer 03 (SGNTUC 029) Comparison of Tucatinib + Trastuzumab + mFOLFOX6 against mFOLFOX6 alone or with cetuximab or bevacizumab.  HER2+ metastatic colorectal cancer who have not received any previous systemic anti-cancer therapy. MMUH & MPH & SVUH (opens in a new window)Click here Medicinal Trial Open
PaTcH 20-27 This study is designed to investigate the means by which treatment-resistant pancreatic cancer can be overcome by a combination of an established anticancer drug, trametinib, with hydroxychloroquine. People with advanced metastatic pancreatic adenocarcinoma or poorly differentiated pancreatic adenocarcinoma.  MMUH & SVUH (opens in a new window)Click here Medicinal Trial Open
BOLD-100-001 (TRIO039) 

A phase 1b/2a study of BOLD-100 in combination with FOLFOX chemotherapy in patients with pre-treated advanced gastric and biliary tract cancer: Efficacy and safety analysis.

 People with a histologically and/or cytologically confirmed gastrointestinal tumours that are metastatic or unresectable, and are subject to receive FOLFOX as SOC per investigator's judgement. SVUH (opens in a new window)Click here Medicinal Trial Open

For details of all gastrointestinal studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Genitourinary Sstudies are research studies/trial of cancers located in the urinary tract or male genitals, such as the kidney, bladder, prostate, or testicles.

The current portfolio of UCD Cancer Trials Cluster genitourinary studies are detailed below:

Name Purpose For People with Our location More Info Study Type Status
IRONMAN Prostate Cancer Outcomes: An International Registry to Improve Outcomes in Men with Advanced Prostate Cancer/ IRONMAN Men with Metastatic Hormone Sensitive Prostate Cancer (mHSPC), Castration Resistant Prostate Cancer (CRPC), and men with prostate cancer who have mixed histological types. SVUH (opens in a new window)Click here Observational Study Open
MK-5684-003 To compare 'MK-5684' with hormone replacement therapy (HRT), to alternative abiraterone acetate or enzalutamide. Metastatic Castration-Resistant Prostate Cancer, Prostatic Neoplasms. SVUH (opens in a new window)Click here Medicinal Trial Open
MK-5684-004 Compare the drug 'MK-5684' to Alternative Abiraterone Acetate or Enzalutamide  People with metastatic castration-resistant prostate Cancer (mCRPC) who have progressed on/after previous treatment. SVUH (opens in a new window)Click here Medicinal Trial Open
MK-5684-01A  To evaluate the safety and effectiveness of MK-5684, either on its own or in combination with other treatments. Metastatic castration resistant prostate cancer. SVUH (opens in a new window)Click here Medicinal Trial Open
PEACE-6 Vulnerable Compare the effectiveness and safety of a combination treatment called androgen deprivation therapy (ADT) with or without darolutamide in frail men who have recently been diagnosed with advanced prostate cancer. Men with prostate cancer whose cancer has recently become metastatic. SVUH & MMUH & MPH (opens in a new window)Click here Medicinal Trial Open
22-17 SAMURAI  To test whether the addition of radiation to the primary tumour, typically given with stereotactic ablative radiation therapy (SABR), in combination with standard of care immunotherapy improves outcomes in patients with renal cell cancer. Patients with renal cell cancer that is not recommended for surgery and has spread from where it first started (primary site) to other places in the body (metastatic). SVUH via via St Luke’s Radiation Oncology Network  (opens in a new window)Click here  Radiotherapy Trial Open
SGVDV 001 An Open-label, Randomized, Controlled Phase 3 Study of Disitamab Vedotin in Combination with Pembrolizumab Versus Chemotherapy. Patients with Previously Untreated Locally Advanced or Metastatic Urothelial Carcinoma that Expresses HER2 (IHC 1+ and Greater). MMUH TBD Medicinal Trial Opening Soon 

For details of all genitourinary studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Gynaecological studies are research studies/trial of cancers located in the female reproductive organs, such as the ovaries, uterus, cervix, vagina, and vulva. 

The current portfolio of UCD Cancer Trials Cluster gynaecology studies are detailed below:

Name Purpose For People with Our location More Info Study Type Status
MK-2870-020  Study of the drug MK2870 compared with an investigator's choice of chemotherapy  Second line recurrent or metastatic cervical cancer. MMUH (opens in a new window)Click here Medicinal Trial Open
MK2870-033 

Ph3, Randomized, open-label, 1L sac-TMT maintenance inTROP2 all-comer pMMR 

 People with endometrial cancer. MMUH TBD Medicinal Trial Opening Soon 

For details of all gynaecological studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Head and neck cancer studies address cancers of the head and neck region, including the mouth and throat. The UCD Cancer Trials Cluster does not currently conduct studies of head and neck cancers. However, please refer to our list of 'basket studies' which may be relevant. 

For details of all head and neck studies available in Ireland, please refer to (opens in a new window)Cancer Trials Ireland. 

Lung studies are research studies/trial targeted towards lung cancers, such as small cell lung cancer, non-small cell lung cancer, etc. The current portfolio of UCD Cancer Trials Cluster lung studies are detailed below:

Name Purpose For People with Our location More Info Study Type Status
NeoCOAST-2 To study the effect of different combinations of drugs, like Durvalumab, Oleclumab, Monalizumab, AZD0171, and others are safe and effective around the time of surgery.  Non-Small Cell Lung Cancer  (NSCLC) where surgery is a treatment option.  MMUH (opens in a new window)Click here Medicinal Trial

Open
SOURCE-LUNG

Examining the use of a new radiotherapy technique over 8 treatments rather than the typical 30-33 treatments. 

 Inoperable (medically or by choice), early stage, high-risk centrally located lung cancer. MMUH & SVUH via St Luke’s Radiation Oncology Network  (opens in a new window)Click here Radiotherapy Trial  Open
GC1T1046-06 

A Prospective, Open-Label, Randomized, Phase 3 Trial of Acasunlimab (GEN1046) in Combination with Pembrolizumab versus Docetaxel.

 People with PD-L1 Positive Metastatic Non-Small Cell Lung Cancer After Treatment With a PD-1/PD-L1 Inhibitor and Platinum-Containing Chemotherapy (ABBIL1TY NSCLC-06) SVUH TBC Medicinal Trial Opening Soon (Pending Greenlight)
BMS CA2390004 (KRYSTAL 4)

To evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy 

Participants with Previously Untreated, Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) with KRAS G12C Mutation

 MPH (opens in a new window)Click Here Medicinal Trial Open

TACTI-004

To compare eftilagimod alfa (efti) in combination with pembrolizumab and chemotherapy versus placebo in combination with pembrolizumab and chemotherapy with respect to overall survival (OS) and progression-free survival (PFS) per Response Evaluation Criteria

 Participants with advanced/metastatic non-small cell lung cancer (NSCLC)  MMUH (opens in a new window)Click Here  Medicinal Trial Open
RMC-6236

Phase 3 Multicentre, Open Label, Randomized Study of RMC-6236 versus Docetaxel 

Participants with Previously Treated Unresectable or Metastatic NSCLC Harboring RAS Mutations

 MPH TBC Medicinal Trial Opening Soon

For details of all lung studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Lymphoma and blood cancers studies are research studies/trials of cancers of the blood stream and immune system, such as leukaemia, myeloma, and myelodysplastic syndromes.

The current portfolio of UCD Cancer Trials Cluster lymphoma and blood cancer studies are detailed below:

Name Purpose For People with Our location More Info Study Type Status
ASTER ANT 007  Compare the effect of a drug called abelacimab to another drug called apixaban.  Venous thromboembolism (VTE) recurrence and bleeding in people in cancer MMUH (opens in a new window)Click here Medicinal Trial Open
MajesTEC-4 Compare the effectiveness of Teclistamab combined with Lenalidomide versus the drugs administered on their own.  People with newly diagnosed multiple myeloma as maintenance therapy following stem cell transplant.  SVUH (opens in a new window)Click here Medicinal Trial Open
MOSAICC The MOSAICC study (MyelOproliferative neoplasmS: An In-depth Case-Control) aims to identify what causes myeloproliferative neoplasms (MPNs) and the best way to improve patients’ quality of life.  People with a diagnosis of myeloproliferative neoplasms (MPNs)  SVUH & MMUH (opens in a new window)Click here Observational study

Open
Myeloma MRD Explore how a person's genetic profile affects their response to treatment and overall survival. Myeloma SVUH NA Observational study

Open
The Frailty study Tracking Frailty in Older Adults with Haematological Malignancies during Treatment.  Older Adults with Haematological Malignancies SVUH NA Observational study

Open
ARGX-113-2402 (advance NEXT) To evaluate the efficacy and safety of Efgartigimod IV.  Adults with Primary Immune Thrombocytopenia MMUH (opens in a new window)Click here Medicinal Trial Open

GIV-IN PV TRIAL

 To assess the efficacy and safety of GIVinostat versus hydroxyurea IN JAK2V617F-positive high-risk Polycythemia Vera patients.  Adults (60 years old or more), diagnosed with Polycythemia Vera MMUH (opens in a new window)Click here  Medicinal Trial Open 

For details of all lymphoma and blood cancer studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Paediatric cancer studies are research studies/trials that affect children, adolescents, and young adults. 

Paediatric trials are managed via Cancer Trials Ireland and Children's Health Ireland. 

For details of all paediatric studies available in Ireland, please refer to (opens in a new window)Cancer Trials Ireland. 

Sarcoma studies are research studies/trial of cancers that start in the bones and soft tissues of the body. The current portfolio of UCD Cancer Trials Cluster sarcoma studies are detailed below:

Name Purpose For People with Our location More Info Study Type Status
CabOSTar (CLIN-60000-461)  To assess the a) efficacy, b) safety, and c) how the body processes the drug (pharmacokinetics) of maintenance cabozantinib (XL184) plus best supportive care (BSC). This is compared to just BSC. Children, adolescents and young adults (AYA) with unresectable residual osteosarcoma either at diagnosis or at first relapse after standard treatment. SVUH (opens in a new window)Click here Medicinal Trial Open
Median-Ph2 INBRX-109 This Phase 2 study is testing a treatment called INBRX-109 for conventional chondrosarcoma. The study will compare the effectiveness of INBRX-109 to a placebo in patients at any stage of treatment. People with conventional chondrosarcoma, unresectable (inoperable) or metastatic SVUH (opens in a new window)Click here Medicinal Trial Recruitment Closed

For details of all sarcoma studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Skin cancers are cancers that affect the skin, such as melanoma, squamous cell carcinoma, and basal cell carcinomas. 

The current portfolio of UCD Cancer Trials Cluster skin cancer studies are detailed below:

Name Purpose For People with Our location(s) More Info Study Type Status
MelMarT-II  A randomised trial to determine the safety and effectiveness of using a 1cm margin versus a 2cm when removing a melanoma.  An invasive cutaneous melanoma MMUH (opens in a new window)Click here Surgical trial Open
Regeneron R3767-ONC-2011 The primary objective of the study is to assess if Fianlimab + Cemiplimab is superior to Pembrolizumab in treating melanoma, as measured by progression-free survival (PFS) Advanced melanoma that cannot be surgically removed (Stage III or Stage IV) SVUH (opens in a new window)Click here Medicinal Trial Recruitment Closed
RS23-048 ctDNA in Uveal Melanoma Tracking cancer DNA in blood to helping doctors keep track the disease and predict what might happen next. Uveal melanoma SVUH NA Translational Study Open

For details of all skin cancer studies available nationally, please refer to (opens in a new window)Cancer Trials Ireland. 

Contact the UCD Cancer Trials Cluster

UCD Clinical Research Centre, St Vincent's University Hospital, Elm Park, Dublin 4
E: cancertrials@ucd.ie