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Conway Fellows (by Theme)

At UCD Conway Institute, we use interdisciplinary research approaches for the exploration of fundamental mechanisms of chronic disease in order to develop novel diagnostic & therapeutic solutions. We have developed a matrix structure in our research programme that stimulates collaborations across themes.

Browse the thematic research areas below to find Conway Fellows, bearing in mind that some may have research projects in more than one thematic area.



Diabetes & Vascular Biology:

Keywords: hypertension, heart disease, heart failure

My team focus on translational research in heart failure, specifically on the development of prognostic and diagnostic biomarkers and novel therapeutics for diastolic dysfunction. We also investigate therapeutics for pulmonary fibrosis .

Keywords: arteriosclerosis, macrophage biology, lipid biology, cardiovascular disease

Our current programme of research investigates the fundamental mechanisms governing atherosclerosis regression. Our laboratory has established a novel model of atherosclerosis regression in vivo, achieved by administration of conjugated linoleic acid (CLA) apoE knockout mouse model of atherosclerosis.

Keywords: oral delivery, diabetic drugs, oral peptide and macromolecule delivery, intestinal epithelial biology, in vivo pharmacokinetics, intra-articular delivery of anti-arthritic nanoparticles

The science of oral peptide delivery addresses how to convert normally injected biotech peptides and proteins to convenient oral forms for patients, such as oral insulin. However, the problem is that such molecules are unstable in the gut and are poorly absorbed so they require nanoparticle-based technologies to address these issues. We have a range of technologies and bioassays to contribute. We leverage such technologies into other therapeutic areas with unmet needs, such as delivery of nanoparticle-peptides into joints for arthritis.

Keywords: obesity, diet, metabolic syndrome, metabolomics, nutrigenomics

My research interests revolve around metabolism and altered metabolic pathways in health and disease. We currently employ nutrigenomic techniques (metabolomics, proteomics and transcriptomics) to further our understanding of the relationship between nutrition and health. Of particular interest is the development of metabolomics for nutritional research.

Keywords: Chronic lung disease pathogenesis, hypoxia, pulmonary vasculature, CXCL11/CXCL12 biological axis

I am interested in understanding the lung specific mechanisms through which hypoxia promotes structural changes in blood vessels and increased blood pressure in chronic lung diseases. Understanding these mechanisms may allow us to identify potential therapeutic strategies so as to target the disease process within the lung without causing unwanted adverse effects in other organs. We seek to identify lung-selective genes and lung-selective microRNAs that contribute to the unique response of the pulmonary vasculature to low oxygen levels.

Keywords: fibrosis, growth factors, signalling matrix

My focus is on the interplay between CCN proteins and the TGF? superfamily in diabetic nephropathy.

Keywords: growth, metabolism

My research interests are focused on a family of insulin growth hormone binding proteins (IGFBPs) which regulate IGF bioavailability and thus bioactivity. Reduced IGF-I bioavailability is a feature of type 1 and type 2 diabetes and there is growing evidence that this is an important factor in the pathophysiology of these disorders.

Keywords: Lipid metabolism, insulin signalling, gene expression, cell cycle regulation.

The group works on the SREBP family of transcription factors that control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation and insulin-dependent gene expression. Disturbances in lipid metabolism are at the very core of several major health issues facing modern society, including cardiovascular disease, obesity and diabetes. So, the factors and signals that regulate the function of the SREBP family of proteins are very relevant to metabolic disease.

Keywords: PPAR-gamma, unsaturated lipid type, natural products, protease inhibitors, anti-angiogenic compounds, natural products, analogues

We are engaged in devising new methods for the chemical synthesis of natural products and their analogues with a view to both inventing and exemplifying new types of chemical reactions and also to investigating the biological activities of the synthesised targets. Targets include fatty acid metabolites and alkaloids with a range of biological effects including anti-inflammatory, anti-angiogenic, cytotoxic and CNS activity

F

Keywords: Heart & lung transplant pathology, interstitial lung diseases, lung cancer and cardiac/cardiovascular pathology

I provide national expertise in interstitial lung disease and in adult sudden cardiac death, working closely with respiratory consultants and cardiothroacic surgeons. At research levels, I provide expertise in tissue and cell morphology, image analysis, animal models and immunohistochemistry.

Keywords: diabetic kidney disease, resolution of inflammation, diabetic complications, macrophages, signal transduction, gene expression

Our focus is on the molecular mechanisms underlying the initiation, progression and potential regression of diabetic kidney disease; genome wide association study of diabetic kidney disease and lipoxins and lipoxin stable analogues as modulators of inflammatory arthritis

Keywords: structural biology, diabetes, obesity, NMR spectroscopy

Our group is currently working on several research projects to look at the various ways to develop new drugs and alternative therapy in treatment of diabetes and other human diseases.

Keywords: Hypoxia, Inflammation, Fibrosis, Biomarker, Chronic Kidney Disease, Diabetes, Hypertension

my research has focussed intensively on the molecular processes which are altered in diseased kidneys. My studies have identified hypoxia, or insufficient oxygen, as a critical micro-environment which controls both pro-inflammatory and pro-fibrotic processes which are fundamental to kidney disease progression. I am currently examining how hypoxia-regulated pathways may be exploited in an effort to develop novel diagnostic and treatment strategies for DN. This research employs a variety of pre-clinical models of kidney disease along with analysis of CKD patient samples.

Keywords: PTO, vascular haematosis, cardiovascular mechanisms

We aim to elucidate the molecular mechanisms of prostanoid-mediated intracellular signalling and of the factors regulating the transcriptional expression of the TP and IP genes with the objective of obtaining a detailed understanding of TXA2- and prostacyclin-regulated haemostasis and vascular tone as well as their contribution to cardiovascular disease.

Keywords: Cardiovascular, diabetes, regenerative medicine, medical devices, preclinical pharmacology

I have successfully directed several projects in preclinical / clinical pharmacology, specifically in cardiovascular pathophysiology, diabetic complications, medical devices, arthritis, and regenerative medicine, which has resulted in either patentable products and/or high impact publications.

Keywords:

I have shown that early diabetic kidney disease (DKD) in obese patients can be reversed by Roux-en-Y gastric bypass (RYGB) surgery. Understanding the underlying mechanisms of such reversal will provide vital clues for innovative therapies and biomarkers of DKD regression/progression.

Keywords: platelets, megakaryocytes, cardiovascular disease, atherosclerosis, proteomics

We discovered new signalling machinery in platelets, termed WNT signalling, and can demonstrate that activation of a distinct subset of this machinery can negatively control platelet function. We now aim to investigate how the full complement of WNT machinery regulates platelet activity.

Keywords: falcipains inhibitors, malaria, enzyme inhibitors, uPA

We focus on synthesising protease inhibitors and studying how they interact with the proteases in order to help develop drugs for treating breast cancer and malaria

Keywords: pregnancy, fetal medicine, diabetes, ultrasound, fetal cardiology, nutrition

Key research areas are 1) Diabetes in pregnancy; research into the effect on mother and baby of pre pregnancy diabetes and of gestational diabetes 2) Nutrition in pregnancy; examination of the impact of maternal nutrition on maternal health and infant health 3)Ultrasound imaging in pregnancy; expanding the diagnostic role of ultrasound in its assessment of fetal health and fetal growth

Keywords: obesity, high-density lipoprotein (HDL) function, reverse cholesterol transport, inflammation, hepatosteatosis and diet

I am interested in the impact of obesity and inflammation on HDL function and cardiovascular health. A key goal of this research is to establish the effects of the obesigenic environment on the capacity of macrophages to mediate cholesterol efflux to HDL particles.

Keywords: lung disease, hypoxia, pulmonary hypertension, angiogenesis, acute lung injury

My research group is focused on the exploration and understanding of key mechanisms in the development and progression of lung diseases. We aim to identify potential therapeutic strategies that can be used to target the disease process within the lung without causing unwanted adverse effects in other organs.

Keywords: kidney disease, toxicology, cell signalling, biomarker identification and analysis

Our research focus is to investigate some of the causes of kidney disease. We have identified a number of proteins that malfunction during the development of kidney disease and are investigating the importance of these proteins in causing disease so as to identify novel early biomarkers and potential therapeutic strategies.

Keywords: metabolic disease, obesity, hypoxia

Sleep apnoea

Keywords: Diabetes, renal pathophysiology, chemoresistance, cancer biology, fibrogenesis, stenosis, biomarkers

The focus of my research is the identification and functional characterisation of novel therapeutic targets with the aim of developing improved therapeutics and diagnostics for fibrotic disease (including diabetic kidney disease) and more recently for cancer.

O

Keywords: high content imaging, predictive toxicology, cardiac biomarkers

We have invented and validated a predictive cell-based assay for screening drug candidates for their risk of producing idiosyncratic hepatotoxicity and various other toxicities. We are further developing this method to enhance its user-friendliness and predictive effectiveness as well as adapting it for use in detection of on-going toxicity in vivo.

Keywords: medical devices, microfluidic devices, cell biomechanics

I am interested in working with clinicians and scientists to identify clinical needs and develop appropriate solutions with a strategic focus on targeted, minimally invasive delivery of next-generation therapeutics

Keywords: obesity

The gut hormone regulation of innate immunity and innate immune cell regulation of weight in adult and paediatric obesity

Keywords: insulin resistance, obesity, nutrition, aging and health, innate inflammation

Our Nutrigenomics Group focuses on the molecular basis of diet induced obesity, insulin resistance and diabetes. There is a strong inflammatory aspect to our work, as we are particularly focused on how dietary/metabolic stressors trigger a pro-inflammatory insulin resistant state.

Keywords: platelets, thrombosis, cell signalling

We are studying the mechanisms of platelet inhibition with the aim of identifying new diagnostic markers of platelet reactivity as well as targets for improved antiplatelet therapy.

Cancer

Keywords: Ovarian cancer, diagnostics, neurodegeneration, Alzheimer's disease, MCI, adaptive immunity

We study proteins and the immune response in patients with auto-immune diseases and cancer. Our aim is to identify patterns of proteins that can be used to better diagnose diseases, which can lead to better treatments and a higher cure rate for patients.

D

Keywords: cancer, breast cancer, biomarkers, therapy

Development of new biomarkers and therapeutics for breast cancer

Keywords: Lipid metabolism, insulin signalling, gene expression, cell cycle regulation.

The group works on the SREBP family of transcription factors that control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation and insulin-dependent gene expression. Disturbances in lipid metabolism are at the very core of several major health issues facing modern society, including cardiovascular disease, obesity and diabetes. So, the factors and signals that regulate the function of the SREBP family of proteins are very relevant to metabolic disease.

G

Keywords: functional genomics, molecular diagnostics, in vivo imaging, breast cancer, melanoma, biomarkers, tissue microarrays

The identification and validation of biomarkers of breast cancer and melanoma is a major research focus in our group. Biomarkers act as a signature for a specific disease and are used to develop diagnostic tests, enable more targeted treatment strategies and can provide rapid information on the effectiveness of cancer treatment.

Keywords: drug development, protide drugs, nucleoside drugs, novel sugars

Nucleosides are an important drug class that includes some well-known anti-viral and anti-cancer drugs such as Zovirax (cold sores), AZT (HIV) and Gemzar (anti-cancer). There is a limitation on the development of such drugs as their activation within the target cells in the body often is not very efficient. We discovered an easy way to make phosphorus compounds for use in the structure of ‘ProTide’ drugs to enable the self-activation of these nucleosides.

Keywords: neurodegeneration, neurotherapeutics, neurogenetics, visual function, anti-angiogenetic drugs, developmental and pathological angiogenesis

We focus on genetic pathways and the pharmacological agents that modulate visual function and disease. We use genetic approaches to identify genes and pathways that mediate eye development, development of visual function and cone photoreceptor function. In parallel, we apply random and targeted small molecule drug screens to identify novel compounds that inhibit intraocular angiogenesis in the eye or drugs that modulate vision function in vivo.

Keywords: systems medicine, network fragilities, therapeutical targets, drug combinations

My group employs systems biology driven discovery and validation approaches to develop quantitative, dynamic models of signalling and gene networks that control cellular responses to external cues and thereby cell fate decisions

Keywords: signal transduction, systems biology, proteomics, cancer biology

My research is focused across three areas: MAPK signalling, proteomics, and cancer research, especially in regard to using systems biology approaches.

Keywords: cell death, cell division, mitosis, anti-mitotic agents

Our research is focused on further understanding the molecular mechanisms of cell division and cell death and how crosstalk between these distinct processes regulates cell fate. We are examining the precise role of mitotic kinases and phosphatases as key upstream regulators of cell death.

Keywords: chemoresistance, epigenetic reprogramming in hypoxia, miRNA targeting and regulation, senescence, autophagy

My research interests focus on the mechanisms underlying Paclitaxel chemoresistance for patients presenting with epithelial ovarian cancer and breast cancer, specifically triple negative breast cancer. I also focus on how DNA methylation and histone modifications are altered in hypoxia and how this relates to ultimate chemoresistance and retention of cellular viability in the face of chemotherapeutic engagement.

Keywords: Diabetes, renal pathophysiology, chemoresistance, cancer biology, fibrogenesis, stenosis, biomarkers

The focus of my research is the identification and functional characterisation of novel therapeutic targets with the aim of developing improved therapeutics and diagnostics for fibrotic disease (including diabetic kidney disease) and more recently for cancer.

Keywords: Haemostasis, thrombosis, vascular biology, maternal health, cancer metastasis

My principal research focus is to investigate the role of coagulation and inflammation in human disease, particularly in disorders affecting maternal health. Current funded projects include investigating coagulation activation in early onset preeclampsia, a disorder associated with maternal and fetal morbidity and mortality; and optimising low molecular weight heparin (LMWH) endothelial protective properties in an effort to identify novel prevention strategies in cancer metastasis.

O

Keywords: high content imaging, predictive toxicology, cardiac biomarkers

We have invented and validated a predictive cell-based assay for screening drug candidates for their risk of producing idiosyncratic hepatotoxicity and various other toxicities. We are further developing this method to enhance its user-friendliness and predictive effectiveness as well as adapting it for use in detection of on-going toxicity in vivo.

Keywords: medical devices, microfluidic devices, cell biomechanics

I am interested in working with clinicians and scientists to identify clinical needs and develop appropriate solutions with a strategic focus on targeted, minimally invasive delivery of next-generation therapeutics

Keywords: Proteomics, prostate cancer, psoriatic arthritis, biomarker discovery, biomarker evaluation, radiation therapy, patient engagement

Current interests and funded projects focus on the discovery, measurement and evaluation of protein biomarkers. We aim to progress protein biomarkers from discovery to clinical utility in the areas of oncology and inflammatory disease. We also investigate mechanisms of disease progression focusing on prostate cancer and psoriatic arthritis. We have recently used LC-MS/MS methods to characterise protein expression in discrete regions of prostate tumour following isolation of tumour tissue material by laser capture micro dissection.

Keywords: Cancer, epigenetics, prostate cancer, DNA methylation, biomarkers, urine, liquid biopsies

My research interests are focused on translational prostate cancer epigenetics; understanding the role of epigenomic aberrations in the pathogenesis of prostate cancer and harnessing these aberrations to develop prognostic and predictive biomarkers. My group has a particular interest in studying DNA methylation changes in the prostate gland and in 'liquid biopsies' that can act as surrogates for non-invasive tumour detection and monitoring.

W

Keywords: biomarkers, prostate cancer, targeted agents, hormone therapies, validation, proteomics

My focus of research is in prostate cancer with specific interests in 1) Biomarker discovery and validation for grade and stage of prostate cancer to inform appropriate treatment strategies; 2) Understanding the mechanisms of resistances to therapy of advanced disease.

Z

Keywords: carbohydrate chemistry

We develop new methodologies for the synthesis of carbohydrate and glycoconjugates, including development of new glycosylation methods. Also, we are interested in the synthesis of thioglycoside analogues of natural carbohydrates and glycoconjugates .

Neuroscience

Keywords: Ciliopathies; C elegans model system

We employ genetics, cell biology and advanced imaging approaches to investigate the molecular basis of cilium formation and function. These microtubule based organelles extending from the surfaces of most eukaryotic cell types serve critical functions in cell and fluid motility, chemo-/photo-/mechano- transduction and developmental signalling. Defects in cilium function lead to many human diseases including polycystic kidney disease, retinitis pigmentosa, as well as multisymptomatic disorders such as Bardet-Biedl syndrome.

Keywords: Ovarian cancer, diagnostics, neurodegeneration, Alzheimer's disease, MCI, adaptive immunity

We study proteins and the immune response in patients with auto-immune diseases and cancer. Our aim is to identify patterns of proteins that can be used to better diagnose diseases, which can lead to better treatments and a higher cure rate for patients.

Keywords: neuro-endocrinology of reproduction

As part of the Reproductive Biology Research Cluster, we focus on specific aspects of female infertility in order to identify molecules in ovarian follicles, oocytes, embryos and the cervix and uterus that are responsible for, or are markers of, infertility. This is achieved by using established large animals of fertility/infertility, in vitro cell culture techniques and the latest technological advances in the biosciences to study the structure and function of complex molecules.

Keywords: autism, genetic predisposition to breast cancer, inherited conditions in Irish Travellers, ethics in paediatric and genetic research

Research interests focus on the application of modern genetic technology in a range of clinical conditions, including inherited neurological disease and cancer as well as ethical aspects of research in paediatrics and in genetics.

H

Keywords: depression, sickness behaviour, neurotransmitter transporters

Understanding function and regulation of the serotonin transporter (SERT), a neurotransmitter transporter implicated in various mood and behavioural disorders and a key target of currently prescribed antidepressants. We are also interested in peripheral functions such as during platelet activation.

Keywords: neurodegeneration, neurotherapeutics, neurogenetics, visual function, anti-angiogenetic drugs, developmental and pathological angiogenesis

We focus on genetic pathways and the pharmacological agents that modulate visual function and disease. We use genetic approaches to identify genes and pathways that mediate eye development, development of visual function and cone photoreceptor function. In parallel, we apply random and targeted small molecule drug screens to identify novel compounds that inhibit intraocular angiogenesis in the eye or drugs that modulate vision function in vivo.

L

Keywords: growth cone guidance, bionanoscience, single molecule measurements, microfabrication, biosensing, phage display, nanoparticles

My group works in the emerging field of bionanotechnology, primarily focused on the study of intra- and intermolecular forces in biological molecules responsible for the rich structural and functional behaviour of biological systems; and the synthesis of functional materials that are composed of biomolecules conjugated to nanoparticles.

Keywords:

Clinical genetics of mood and psychiatric disorders

Keywords: neurodegeneration, neurotherapeutics, neurotransmission, neuroprotection

My research is centred on understanding how glial cells in the brain and central nervous system function in supporting and protecting neurones from damage leading to cell death and degeneration. I also investigate the mechanism of neurotoxicity associated with MDMA (‘Ecstasy’) and its analogues in the brain.

Keywords:

My group works in the area of prion related disorders that affect both animals and humans and share similarities with Alzheimer’s disease (AD). Abnormal processing of a disease associated endogenous protein is found in both systems. We are investigating the link between the prion protein and AD and also processes to eliminate prion associated disorders through the development of new decontaminants.

Keywords: neurotherapeutics, learning and memory, synaptic plasticity, transcription control, schizophrenia, multiple sclerosis, neuroinflammation

Our research group is dedicated to the identification of novel drug targets for the treatment of age-related neurological and neurodegenerative diseases such as schizophrenia, depression, Alzheimer’s disease and multiple sclerosis.

Keywords: neuroimmune biology, neurotransmission, neurodegeneration, stroke, hypoxia, neurophysiology

My group are interested in neuron to neuron signalling in the brain and how the immune system interacts with this. We are particularly interested in how pro inflammatory molecules modulate synaptic plasticity (a model for memory formation) before and during hypoxic insults to neurons. We are currently investigating how neurons adapt to acute hypoxic exposure.

Keywords: Models of neurodegeneration; cell biology

Research in my lab aims to uncover the role of the smooth ER in neurons and how disruption of this organelle, brought about by disease-causing variants in ER-shaping proteins, gives rise to neurodegeneration. By generating novel in-vivo and in-vitro model systems, we aim to better understand the functions of genes underpinning inherited neurodegenerative diseases.

Infection, Inflammation & Repair

B

Keywords: Host-pathogen interaction, innate immunity, pharmacology, mucosa, epithelium, inflammation.

Epithelial function is studied using a range of technologies. We are interested in the role of other cells (nerves, immune cells, endocrine cells) in the regulation of epithelial function. The same models are used in drug discovery and in the design of drug delivery strategies. We use intact tissues with complex structural organisation to examine the relationship between mammals and microorganisms.

Keywords:

My main laboratory research interest is in infectious diarrhoeal diseases of childhood and my group focuses particularly on Campylobacter jejuni, a major human intestinal pathogen and the most common cause of bacterial gastroenteritis. We explore the manner in which pathogenicity is modulated by the host but also investigate the role of mucous and mucins in Campylobacter infection.

Keywords: pathogen genomics, virulence, transcriptomics, microarrays, RNA-seq, evolution

Candida species are among the most common cause of fungal infection worldwide, and have high attributable mortality rates. We work predominantly with C. parapsilosis, which is of particular concern in premature babies and in the old. It grows as biofilms, or living mats, on indwelling medical devices. Biofilms are very resistant to antifungal drugs, making infections difficult to treat. We have identified regulators of biofilm growth that may lead to the development of new therapies.

Keywords: host-pathogen interaction, bacterial virulence

My area of interest is how bacteria interact with human and animal tissue and cause disease. The group work with Helicobacter pylori, Campylobacter jejuni and Pseudomonas aeruginosa. An area of particular interest is how bacteria colonise and live in mucus.

Keywords: neuro-endocrinology of reproduction

As part of the Reproductive Biology Research Cluster, we focus on specific aspects of female infertility in order to identify molecules in ovarian follicles, oocytes, embryos and the cervix and uterus that are responsible for, or are markers of, infertility. This is achieved by using established large animals of fertility/infertility, in vitro cell culture techniques and the latest technological advances in the biosciences to study the structure and function of complex molecules.

Keywords: Hypoxia, hyercapnia, cell signalling, inflammation

The focus of our research is how different levels of the physiological gases oxygen and carbon dioxide contribute to cell signalling, particularly in the context of inflammation. Current projects are directed towards understanding the mechanisms underpinning the cellular sensitivity to carbon dioxide and cross talk between oxygen and carbon dioxide signalling pathways.

Keywords: host-pathogen interaction

As part of the Reproductive Biology Research Cluster, we focus on specific aspects of female infertility in order to identify molecules in ovarian follicles, oocytes, embryos and the cervix and uterus that are responsible for, or are markers of, infertility. This is achieved by using established large animals of fertility/infertility, in vitro cell culture techniques and the latest technological advances in the biosciences to study the structure and function of complex molecules.

Keywords: psoriatic arthritis, synovium, genetics, proteomics

Key research disease area is inflammatory arthritis (IA) in particular psoriatic arthritis. At SVUH, we have built up a large clinical cohort of inflammatory arthritis patients with defined clinical and radiographic phenotype on a longitudinal database. Our bio-resource facilitates the study of disease mechanisms and mode of action of therapeutic interventions.

Keywords:

My research interests are in the application of genomic technologies as a route to improved understanding of disease and the exploitation of this knowledge for improved control tools. Current research focuses on improved diagnostics for bovine tuberculosis and Johne's disease.

Keywords: lipoxins and thromboxane inhibitors, synthetic organic chemistry, asymmetric synthesis, total synthesis, inflammation, neurochemistry

Our research group focuses on synthetic organic chemistry and the ability to synthesise molecules with a range of properties. In our work on inflammation, we prepare stable lipoxin analogues with an active region for biological activity but which resist, or more slowly undergo metabolism and have a longer pharmacological activity. We also have a long-standing interest in the chemistry and biology of amphetamines and substituted MDMA analogues.

K

Keywords: remodelling, fibrosis, lung, angiogenesis

Cytokines in lung injury and remodelling

Keywords: host-pathogen interaction, innate immunity

Reactive oxygen species (ROS) play a crucial role in the host immune defence towards pathogens. We use using 3D cellular systems and/or in vivo models in order to gain a better understanding of the interaction between the immune system and pathogens. A current focus is on the complex relationship between mucosal host defence and bacteria that links signalling networks and functional changes in both in an intricate manner.

Keywords:

As part of the Reproductive Biology Research Cluster, we focus on specific aspects of female infertility in order to identify molecules in ovarian follicles, oocytes, embryos and the cervix and uterus that are responsible for, or are markers of, infertility. This is achieved by using established large animals of fertility/infertility, in vitro cell culture techniques and the latest technological advances in the biosciences to study the structure and function of complex molecules.

M

Keywords: host-pathogen interaction, innate immunity

My research activities include functional genomics and systems biology of host/pathogen interactions in domestic animals, with a specific focus on mycobacterial diseases; genomic imprinting and economically important traits in livestock; evolutionary origins and population genetics of domestic cattle; genome mapping in domestic animal species; equine genomics; and application of genomics to commercial animal breeding and food production.

Keywords: falcipains inhibitors, malaria, enzyme inhibitors, uPA

We focus on synthesising protease inhibitors and studying how they interact with the proteases in order to help develop drugs for treating breast cancer and malaria

Keywords: host-pathogen interaction, innate immunity, vaccine and drug development, diagnostics

Research in my group focuses on three areas: water quality, animal reproduction and foal pneumonia. The facultative intracellular pathogen Rhodococcus equi has many physiological and pathological similarities to the related pathogen Mycobacterium tuberculosis.

Keywords: host-pathogen interaction, innate immunity, vaccine and drug development, immunomodulation, co-infection

My research group focuses on host-pathogen interactions, and is actively involved in understanding how helminths interfere with protective immunity to bacterial infections.

Keywords: host-pathogen interaction, virulence gene regulation, Campylobacter, gene regulation, infection biology, pathogenesis, transcription

My group focus on discovering how microorganisms respond to changes in their environment and in particular how they alter their gene expression to cause disease under certain conditions. Much of our work is concentrated on studying the food borne pathogen Campylobacter jejuni.

Keywords: host-pathogen interaction, innate immunity, vaccine and drug development

Syntheses of biologically active oligosaccharides and glycoconjugates and development of methods to facilitate these syntheses. Both human, plant and microbial carbohydrate are of interest and synthesised. Biological applications are as antibiotics or vaccines.

Keywords: Proteomics, prostate cancer, psoriatic arthritis, biomarker discovery, biomarker evaluation, radiation therapy, patient engagement

Current interests and funded projects focus on the discovery, measurement and evaluation of protein biomarkers. We aim to progress protein biomarkers from discovery to clinical utility in the areas of oncology and inflammatory disease. We also investigate mechanisms of disease progression focusing on prostate cancer and psoriatic arthritis. We have recently used LC-MS/MS methods to characterise protein expression in discrete regions of prostate tumour following isolation of tumour tissue material by laser capture micro dissection.

Keywords: insulin resistance, obesity, nutrition, aging and health, innate inflammation

Our Nutrigenomics Group focuses on the molecular basis of diet induced obesity, insulin resistance and diabetes. There is a strong inflammatory aspect to our work, as we are particularly focused on how dietary/metabolic stressors trigger a pro-inflammatory insulin resistant state.

Keywords: host-pathogen interaction, viruses

My research area is molecular virology and specifically relates to the investigation of the pathogenesis of the human retroviruses human T cell leukemia viruses types 1 and 2. Key focus areas are: 1) Regulation of cellular signalling pathways by HTLV Tax oncogenic proteins 2) Investigation of the pathogenesis of leukemia/lymphoma development in ATLL mouse animal model 3)Characterisation of novel HTLV /cellular protein/protein interactions

Keywords: host-pathogen interaction, microbial toxins, drug delivery, membrane traffic, small GTP binding proteins, membrane traffic, cytoskeleton

My main area of work is focused on gaining a greater understanding of membrane trafficking pathways within mammalian cells, and how they are co-ordinated spatially and temporally. In particular, we are dissecting the molecular machinery responsible for trafficking from the cell surface to organelles of the early secretory pathway, and exploring the use of these pathways for their potential as drug delivery routes.

T

Keywords: hypoxia, inflammation

Current research is directed towards expanding our understanding of the mechanisms by which hypoxia regulates transcriptional events in the context of inflammatory disease and cancer. We focus on the regulation of inflammatory gene expression in response to hypoxia and the transcriptional regulators underlying such events particularly in the hypoxia inducible factor and the NF-kappaB pathways.

Keywords: comparative genomics

My research interests lie in the cross-cutting fields of mammalian phylogenetics and comparative genomics, with particular expertise in bat biology.

V

Keywords: angiogenesis, hypoxia, innate and adaptive immunity, drug development

The clinical research focus of our group is early inflammatory arthritis; RA, psoriatic arthritis and related psoriasis.The group has combined high-quality clinical cohort studies with novel arthroscopic and high-end imaging technologies to study synovial tissue in vivo macroscopically, ex vivo and at the cellular and molecular level.

Keywords: genetic and epigenetic influences in rheumatoid arthritis; ageing and epigenetics; pharmacogenetics of biological therapies

Research focuses on athogenesis of inflammatory musculoskeletal diseases

Systems Biology

C

Keywords: Network biology, proteomics, bioinformatics, protein interactions, mass spectrometry

We use systems approaches to study problems of scientific and clinical interest. This means trying to study all the components of a biological system at the same time.

Keywords: endothelial cell biology, mesenchymal stem cells, transplant, regenerative medicine

My major research focus is on endothelial pathology in transplant medicine and on mesenchymal stem cells in transplant and regenerative medicine.

Keywords: bioinformatics, multiple sequence alignment, Clustal, microarray, microRNA

Our group uses computers to analyse large data sets that come from modern genetic analysis experiments, especially gene and genome sequences. We have written computer programmes to allow the comparison of gene sequences from different species so as to help understand how they work or what their role is in disease.

Keywords: systems medicine, network fragilities, therapeutical targets, drug combinations

My group employs systems biology driven discovery and validation approaches to develop quantitative, dynamic models of signalling and gene networks that control cellular responses to external cues and thereby cell fate decisions

Keywords: signal transduction, systems biology, proteomics, cancer biology

My research is focused across three areas: MAPK signalling, proteomics, and cancer research, especially in regard to using systems biology approaches.

Keywords: genomics, sequencing, genome analysis, evolution of virulence, transcriptional response, comparative genomics

My primary research interest is infection biology and the interaction between host and pathogen using transcriptomics and bioinformatics. Other interests involve providing sequencing and bioinformatics in pathogen genomics; human genomics and analyses of personal genomes; using sequencing and bioinformatics to interrogate transcriptional response in infertility; evolution of the transcriptome across pathogen genomes.

M

Keywords: host-pathogen interaction, innate immunity

My research activities include functional genomics and systems biology of host/pathogen interactions in domestic animals, with a specific focus on mycobacterial diseases; genomic imprinting and economically important traits in livestock; evolutionary origins and population genetics of domestic cattle; genome mapping in domestic animal species; equine genomics; and application of genomics to commercial animal breeding and food production.

Keywords:

My research work uses bacteria and their enzymes to develop green technologies for polymer and chemical production.

Keywords:

A key area of my research concerns the health of past populations and the evolution of pathogens and disease using ancient DNA studies of pathogens.

Keywords:

My research group combine computation and experiments to discover novel bioactive oligopeptides, or peptide combinations and chimeras, derived from within human and pathogen proteins.

Keywords: host-pathogen interaction, microbial toxins, drug delivery, membrane traffic, small GTP binding proteins, membrane traffic, cytoskeleton

My main area of work is focused on gaining a greater understanding of membrane trafficking pathways within mammalian cells, and how they are co-ordinated spatially and temporally. In particular, we are dissecting the molecular machinery responsible for trafficking from the cell surface to organelles of the early secretory pathway, and exploring the use of these pathways for their potential as drug delivery routes.

T

Keywords: hypoxia, inflammation

Current research is directed towards expanding our understanding of the mechanisms by which hypoxia regulates transcriptional events in the context of inflammatory disease and cancer. We focus on the regulation of inflammatory gene expression in response to hypoxia and the transcriptional regulators underlying such events particularly in the hypoxia inducible factor and the NF-kappaB pathways.

Keywords: comparative genomics

My research interests lie in the cross-cutting fields of mammalian phylogenetics and comparative genomics, with particular expertise in bat biology.

Keywords: proteomics, functional proteomics, mass spectrometry, informatics, protein complexes, affinity purifications

Director, UCD Conway Proteomics Core. My research focuses on the field of mass spectrometry based proteomics. A mass spectrometric analysis allows the rapid identification of proteins within a sample of biological origin. The aim is to generate a deeper understanding how cellular processes work on the molecular level.

Keywords: comparative genomics, Saccharomycotina genomes

My research area is genome evolution in eukaryotes with a focus on yeasts as a primary system to work on. Current research projects underway are investigating gene gain and loss; orphan genes; gene order evolution; evolution of the yeast MAT locus system.

Translational Medicine

E

Keywords: pulmonary fibrosis, Ebv infection

Keywords: endothelial cell biology, mesenchymal stem cells, transplant, regenerative medicine

My major research focus is on endothelial pathology in transplant medicine and on mesenchymal stem cells in transplant and regenerative medicine.

F

Keywords: Heart & lung transplant pathology, interstitial lung diseases, lung cancer and cardiac/cardiovascular pathology

I provide national expertise in interstitial lung disease and in adult sudden cardiac death, working closely with respiratory consultants and cardiothroacic surgeons. At research levels, I provide expertise in tissue and cell morphology, image analysis, animal models and immunohistochemistry.

K

Keywords: remodelling, fibrosis, lung, angiogenesis

Cytokines in lung injury and remodelling

Keywords: reproductive medicine, oocyte, spermatozoa, fertilisation, embryo, implantation, placentation, embryo-maternal communication

My research is focused on reproductive medicine, especially on improving the results of assisted reproduction. Prof Koelle hopes to combine modern imaging techniques with molecular analyses in proteomics and genomics to create new diagnostic and therapeutic tools in subfertility and infertility.

Keywords: Cardiovascular, diabetes, regenerative medicine, medical devices, preclinical pharmacology

I have successfully directed several projects in preclinical / clinical pharmacology, specifically in cardiovascular pathophysiology, diabetic complications, medical devices, arthritis, and regenerative medicine, which has resulted in either patentable products and/or high impact publications.

Keywords: cystic fibrosis, genetic epidemiology, clinical epidemiology

Keywords: metabolic disease, obesity, hypoxia

Sleep apnoea

Keywords: Haemostasis, thrombosis, vascular biology, maternal health, cancer metastasis

My principal research focus is to investigate the role of coagulation and inflammation in human disease, particularly in disorders affecting maternal health. Current funded projects include investigating coagulation activation in early onset preeclampsia, a disorder associated with maternal and fetal morbidity and mortality; and optimising low molecular weight heparin (LMWH) endothelial protective properties in an effort to identify novel prevention strategies in cancer metastasis.

Keywords: calcium binding proteins, biotechnology

My basic research is focused on the mechanism of action of calcium binding proteins. In applied research, we develop novel EF hand based affinity tags. This patented technology is now the subject of research collaboration with industrial and academic partners.

Keywords: inflammatory bowel disease, pelvic floor physiology and continence

Keywords: Proteomics, prostate cancer, psoriatic arthritis, biomarker discovery, biomarker evaluation, radiation therapy, patient engagement

Current interests and funded projects focus on the discovery, measurement and evaluation of protein biomarkers. We aim to progress protein biomarkers from discovery to clinical utility in the areas of oncology and inflammatory disease. We also investigate mechanisms of disease progression focusing on prostate cancer and psoriatic arthritis. We have recently used LC-MS/MS methods to characterise protein expression in discrete regions of prostate tumour following isolation of tumour tissue material by laser capture micro dissection.

Keywords: Cancer, epigenetics, prostate cancer, DNA methylation, biomarkers, urine, liquid biopsies

My research interests are focused on translational prostate cancer epigenetics; understanding the role of epigenomic aberrations in the pathogenesis of prostate cancer and harnessing these aberrations to develop prognostic and predictive biomarkers. My group has a particular interest in studying DNA methylation changes in the prostate gland and in 'liquid biopsies' that can act as surrogates for non-invasive tumour detection and monitoring.

Keywords: vesicoureteral reflux, Hirschsprung’s disease, congenital diaphragmatic hernia, esophageal atresia, omphalocele, birth defects, animal models of birth defects.

My research focuses on understanding the underlying mechanisms causing some of the common congenital birth defects e.g. Vesicoureteral reflux, Hirschsprung's disease, congenital diaphragmatic hernia and oesophageal atresia.

R

Keywords: Evolution, epithelial biology, 3D bioprinting, 3D biological imaging, light sheet microscopy

The "R"lab (Renaissance) is a multidisciplinary laboratory that used sustainable and inclusive approaches to understand epithelial biology from choanoflagellates to human cancers. We are involved in new technology development from microcontact printing and laser nanosurgery to light sheet microscopy working with companies (e.g. Carl Zeiss; Lighsheet Z.1) as well as NGOs. The use of 3D bioprinted tissues and 3D cell culture techniques is our next goal to push forward 3D cell biology.

V

Keywords: angiogenesis, hypoxia, innate and adaptive immunity, drug development

The clinical research focus of our group is early inflammatory arthritis; RA, psoriatic arthritis and related psoriasis.The group has combined high-quality clinical cohort studies with novel arthroscopic and high-end imaging technologies to study synovial tissue in vivo macroscopically, ex vivo and at the cellular and molecular level.

Keywords: genetic and epigenetic influences in rheumatoid arthritis; ageing and epigenetics; pharmacogenetics of biological therapies

Research focuses on athogenesis of inflammatory musculoskeletal diseases

Cross-Thematic Research

Keywords: enzyme kinetics, protein engineering, site-directed mutagenesis, inborn errors, high-throughput screening, biocatalysis

We work on various aspects of enzymes, the agents that speed up and make possible every chemical process in our cells. We study ways in which they go wrong in various human genetic diseases. We also alter them deliberately by mutations in order to use them as vital tools for the chemical industry. We study them also in depth to understand just how these tiny molecular machines work and are regulated.

J

Keywords:

We are concerned with the design of novel technologies for biomedical applications and the understanding of the structure and function of molecular interactions on the nanometre scale. Our research is mainly focused on the application of novel atomic force microscopy (AFM) instrumentation and techniques, to find solutions for biomedical problems, at both the cellular and molecular scale.

P

Keywords: biocatalysis, enzymology, biotechnology, alcohol dehydrogenases

I am interested in the use of enzymes as biocatalysts for chemical reactions. I focus particularly on halophilic alcohol dehydrogenases and their immobilisation on solid support. I am also interested in the synthesis of small molecules and their potential antimicrobial activity.

Keywords: synthesis, spectroscopy, organometallics, bioorganometallics, anticancer, antibacterial, computational.

My research interests are in the development of sustainable catalytic processes utilising natural products; energy related catalysis, especially in the area of hydrogen storage from ammonia boranes; pioneering new multifunctional anticancer compounds with enhanced selectivity and inhibitor delivery; development of silver antibiotic drugs with biofilm inhibitor behaviour and activity against MRSA bacteria.

Keywords: functional biomaterials, scanning probe microscopy, electrotransduction, nanoscale characterisation, piezoelectricity

My research group focuses on functional biological materials and advanced scanning probe microscopy-based characterisation techniques of biological materials. In particular, we develop and employ techniques to measure electrostatic interactions and electromechanical coupling in biosystems at the molecular level. Our current emphasis is to explore physical interactions between biosystems and materials properties and structure through the use of charged probes and charge-patterned templates.

Keywords:

glycan analysis, mucins, systems biology

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