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UCD Conway SPHERE

UCD Conway SPHERE is a novel translational research group which combines expertise from across the UCD School of Medicine, the UCD School of Biomolecular & Biomedical Science (SBBS) and the UCD Conway Institute focused on inflammatory-based diseases including thromobotic disorders. The group was launched in September 2015 at an international thrombosis conference (www.vtedublin2015.com) co-organised by SPHERE co-Director, Associate Professor Fionnuala Ní Aínle. The launch of SPHERE was welcomed by Dr Leo Varadkar, then Irish Minister for Health, in his address to conference delegates. SPHERE brings together clinical and academic collaborators nationally and internationally, harnessing unique tools to diagnose and understand a host of inflammatory-based diseases, including thrombotic disorders. The acronym SPHERE describes the state-of the art translational interests of the group, which will focus upon “Systemic inflammatory disorders: role of blood Particles, Haemostatic factors and ExtRacEllular vesicles”.

SPHERE research group

L-R: Prof. Patricia Maguire, Dr Karl Egan, Dr Seamus Allen, Dr Barry Kevane, Dr Paulina Szklanna, Ms Brid Holohan, Prof. Fionnuala Ní Áinle, Dr Martin Parsons

Principal Investigators

Professor Patricia Maguire 

• Principal Investigator and Fellow, UCD Conway Institute
• Director, UCD Institute of Discovery
• Associate Professor, UCD School of Biomolecular & Biomedical Science

E: patricia.maguire@ucd.ie
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Professor Fionnuala Ní Áinle 

• Consultant Haematologist, Rotunda Hospital, Parnell Street, Dublin 1
• Consultant Haematologist, Mater Misericordiae University Hospital, Dublin 7
• Clinical Associate Fellow, University College Dublin (UCD) Conway Institute
• UCD Associate Clinical Professor
• Chairperson, Ireland East Health Group (IEHG) Venous Thromboembolism Committee

E: fniainle@mater.ie
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Collaborators

National

• Prof. Peter Kelly and Prof. Sean Murphy, Mater Misericordiae University Hospital Dept. of Stroke Medicine
• Dr Stephen Stewart, Consultant Hepatologist, Mater Misericordiae University Hospital
• Professor Fergal Malone, Master, Rotunda Hospital
• Professor Naomi McCallion, Consultant Neonatologist, Rotunda Hospital
• Dr Jennifer Donnelly, Consultant Obstetrician, Rotunda Hospital
• Dr Chris McGuigan, Consultant Neurologist, St Vincent’s University Hospital
• Prof. Brian Cleary, Chief Pharmacist, RCSI and Rotunda Hospital
• Dr Kevin Walsh, Consultant Cardiologist, Mater Misericordiae University Hospital
• Dr Tomás Breslin, Consultant in Emergency Medicine, Mater Misericordiae University Hospital and Chair, Mater Hospital Venous Thromboembolism Working Group
• Dr Jogin Thakore, Consultant Psychiatrist, St Vincent’s Hospital, Fairview
• Professor Sean Gaine, Consultant Respiratory Physician, Mater Misericordiae University Hospital

International Collaborators

• Prof Saskia Middeldorp, Academic Medical Centre, Amsterdam, the Netherlands
• Prof. Beverley Hunt, King’s College, London, UK
• Prof Willem Ouwehand & Dr Cedric Ghevaert, Cambridge University, UK
• Dr Alastair Poole, Bristol University, UK
• Prof Johan Heemskeerk, Maastricht University, the Netherlands
• Prof. Denisa Wagner, Harvard Medical School, Boston, Massachusets, USA

Publications

Publications by UCD Conway SPHERE directors and group include:

1. Parsons ME, O’Connell K, Allen S, Egan K, Szklanna P, McGuigan C, Ní Áinle F, Maguire PB. Thrombin generation correlates with disease duration in multiple sclerosis (MS): novel insights into the MS-associated prothrombotic state. Mult Scler J Exp Transl Clin. 2017 Dec 26;3(4):2055217317747624. doi: 10.1177/2055217317747624.
2. Monteith C, Egan K, O’Connor H, Maguire P, Kevane B, Szklanna PB, Cooley S, Malone F, Ní Áinle F. Early onset preeclampsia is associated with an elevated mean platelet volume (MPV) and a greater rise in MPV from time of booking compared with pregnant controls: results of the CAPE study. J Perinat Med. 2017 Dec 21. pii: /j/jpme.ahead-of-print/jpm-2017-0188/jpm-2017-0188.xml. doi: 10.1515/jpm-2017-0188. [Epub ahead of print]
3. Parsons ME, McParland D, Szklanna PB, Guang MHZ, O’Connell K, O’Connor H, McGuigan C, Ní Áinle F, McCann A, Maguire P. A protocol for improved precision and increased confidence in Nanoparticle Tracking Analysis concentration measurements between 50-120 nm in biological fluids. Front Cardiovasc Med. 2017 Nov 3;4:68. doi: 10.3389/fcvm.2017.00068. eCollection 2017. PMID: 29164135
4. Kelly B, Mendoza M, Carton E, Doughty H, Ní Áinle F. European Society of Intensive Care Medicine (ESICM) PACT (Patient-centred Acute Care Training) e-module (online learning course) on bleeding and thrombosis in the ICU. PACT, and ESICM product, is an up-to-date, on-line, modular curriculum for Intensive (Critical) Care Medicine. It is an educational resource aimed at advancing and harmonising the quality of Acute and Critical Care Medicine training. https://sso.esicm.org/auth/login?service=https%3A%2F%2Facademy.esicm.org%2Flogin%2Findex.php
5. O’Shaughnessy F, Donnelly J, Cooley S, Deering M, Raman R, Gannon G, Hickey J, Holland A, Hayes N, Bennett K, Ní Áinle F, Cleary B (joint final authors). Thrombocalc: Implementation and uptake of personalized postpartum venous thromboembolism risk assessment in a high through-put obstetric environment. Acta Obstet Gynecol Scand. 2017 Nov;96(11):1382-1390. doi: 10.1111/aogs.13206. Epub 2017 Sep 21.PMID: 28832906
6. Kevane B, Egan K, Allen S, Maguire P, Neary E, Lennon A, Ní Áinle F. Endothelial barrier protective properties of LMWH: a novel potential tool in the prevention of cancer metastasis? Research and Practice in Thrombosis and Haemostasis 2017 (in press; doi 10.1002/rth2.12011)
7. Egan K, O’Connor H, Kevane B, Malone F, Lennon A, Al Zadjali A, Cooley S, Monteith C, Maguire P, Szklanna P, Allen S, McCallion N, Ní Áinle F. Elevated plasma TFPI activity causes attenuated TF-dependent thrombin generation in early onset preeclampsia. Thromb Haemost. 2017 Jul 26;117(8):1549-1557. doi: 10.1160/TH16-12-0949. Epub 2017 Jun 1. PMID: 28569919
8. Kevane B, Ní Áinle F. Contraception and menstrual bleeding during venous thromboembolism treatment: Does current practice reflect expert option? (Editorial). Thromb Res. 2017 May;153:121-122. doi: 10.1016/j.thromres.2017.04.013. Epub 2017 Apr 12. No abstract available. PMID: 28413067
9. Egan K, van Geffen JP, Ma Hui, Kevane B, Lennon A, Allen S, Neary E, Parsons M, Maguire P, Wynne K, O’Kennedy R, Heemskerk JWM, Ní Áinle F. Effect of platelet-derived β-thromboglobulins on coagulation. Thromb Res. 2017 Jun;154:7-15. doi: 10.1016/j.thromres.2017.03.023. Epub 2017 Mar 30. PMID: 28384443
10. Szklanna P, Nolan M, Wynne K, Egan K, Ni AInle F, Maguire P. Comparative proteomic analysis of trophoblast cell models reveals their differential phenotypes, potential uses and limitations. Proteomics. 2017 Mar 20. doi: 10.1002/pmic.201700037. [Epub ahead of print] PMID: 28317260
11. Neary E, Ni Ainle F, El-Khuffash A, Cotter M, Kirkham C, McCallion N. Plasma transfusion to prevent
12. intraventricular haemorrhage in very preterm infants. Protocol publication; Cochrane Database of Systematic Reviews 2016 (in press)
13. McDonnell B, Glennon K, McTiernan A, Kirkham C, Kevane B, Donnelly J, Ní Áinle F. Adjustment of therapeutic LMWH to achieve specific target anti-FXa activity does not affect outcomes in pregnant patients with venous thromboembolism. J Thromb Thrombolysis. 2017 Jan;43(1):105-111. doi: 10.1007/s11239-016-1409-5.
14. Egan K, Dillon A, Dunne E, Kevane B, Galvin Z, Maguire P, Kenny D, Stewart S, Ní Áinle F. Increased soluble GPVI levels in cirrhosis: evidence for early in vivo platelet activation. J Thromb Thrombolysis. 2017 Jan;43(1):54-59. doi: 10.1007/s11239-016-1401-0.
15. Barrett A, Kevane B, Hall P, Ní Áinle F, Breslin T. Screening for malignancy in patients with unprovoked venous thromboembolism: a single-centre retrospective case-series. Clin Appl Thromb Hemost. 2016 Jan 1:1076029616659694. doi: 10.1177/1076029616659694. [Epub ahead of print] PMID: 27443696
16. Bleker, SM, Buchmüller A, Chauleur C, Ní Áinle F, Donnelly J, Verhamme V, Jacobsen AF, Ganzevoort W, Prins M, Beyer-Westendorf J, DeSancho M, Konstantinides S, Pabinger I, Rodger M, Decousus H, Middeldorp S, for the Highlow investigators. Low-molecular-weight heparin to prevent recurrent VTE in pregnancy: rationale and design of the Highlow study, a randomized trial of two doses. Thrombosis Research 2016 Aug;144:62-8. doi: 10.1016/j.thromres.2016.06.001.PMID: 27289488
17. Crowley M, Kevane B, O’Shea S, Quinn S, Egan K, Gilligan O, Ní Ainle F. Plasma thrombin generation and sensitivity to activated protein C among patients with myeloma and monoclonal gammopathy of undetermined significance. Clin Appl Thromb Hemost. 2016 Sep;22(6):554-62. doi: 10.1177/1076029615625825. PMID: 26759370
18. Husarova V, Donnelly G, Doolan A, Garstka M, Ní Áinle F, McCaul C. Preferences of Jehovah’s Witnesses regarding haematological supports in an obstetric setting: experience of a single university teaching hospital. Int J Obstet Anesth. 2015 Sep 25. pii: S0959-289X(15)00133-8. doi: 10.1016/j.ijoa.2015.09.005. [Epub ahead of print] PMID: 26597403
19. Neary E, McCallion N, Kevane B, Cotter M, Egan K, Regan I, Kirkham C, Mooney C, Coulter-Smith S, Ní Áinle F. Coagulation indices in very preterm infants from cord blood and postnatal samples. Journal of Thrombosis and Haemostasis 2015 Nov;13(11):2021-2030. doi: 10.1111/jth.13130. Epub 2015 Sep 25. PMID:26334448
20. Egan K, Kevane B, Ní Áinle F. Elevated venous thromboembolism risk in preeclampsia: molecular mechanisms and clinical impact. Biochem Soc Trans. 2015 Aug 1;43(4):696-701. Epub 2015 Aug 3. Review. PMID: 26551715
21. Werth S, Breslin T, NiAinle F, Beyer-Westendorf J. Bleeding Risk, Management and Outcome in Patients Receiving Non-VKA Oral Anticoagulants (NOACs). Am J Cardiovasc Drugs. Am J Cardiovasc Drugs. 2015 Aug;15(4):235-42. doi: 10.1007/s40256-015-0123-6. PMID: 25940651
22. Neary E, Ni Ainle F, Cotter M, McCallion N. Coagulation values in extreme premature infants. Transfusion. 2014 Aug;54(8):2134. doi: 10.1111/trf.12734 2014 Aug;54(8):2134. doi: 10.1111/trf.12734. PMID: 25130336
23. Langabeer SE, Haslam K, Linders J, Percy MJ, Conneally E, Hayat A, Hennessy B, Leahy M, Murphy K, Murray M, Ni Ainle F, Thornton P, Sargent J. Molecular heterogeneity of familial myeloproliferative neoplasms revealed by analysis of the commonly acquired JAK2, CALR and MPL mutations. Fam Cancer. 2014 Dec;13(4):659-63. doi: 10.1007/s10689-014-9743-2. PMID: 25103330
24. Donnellan E, Kevane B, Bird BR, Ainle FN. Cancer and venous thromboembolic disease: from molecular mechanisms to clinical management. Curr Oncol. 2014 Jun;21(3):134-43. doi: 10.3747/co.21.1864. PMID: 24940094
25. Kevane B, McKenna P, Walsh K, Donnelly JC, Flood K, Cullen M, Bowen M, Thornton P, Loughrey J, Coulter-Smith S, Ainle FN. Haemorrhagic and thrombotic complications in pregnant women with acquired and congenital cardiac disease. J Perinat Med. 2015 Mar;43(2):165-9. doi: 10.1515/jpm-2014-0088. PMID: 25014516
26. Scully M, Thomas M, Underwood M, Watson H, Langley K, Camilleri RS, Clark A, Creagh D, Rayment R, Mcdonald V, Roy A, Evans G, McGuckin S, Ni Ainle F, Maclean R, Lester W, Nash M, Scott R, O Brien P; collaborators of the UK TTP Registry. Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes. Blood. 2014 Jul 10;124(2):211-9. doi: 10.1182/blood-2014-02-553131. Epub 2014 May 23. PMID: 24859360
27. Macaulay IC, Thon JN, et al, He X, Fitzgerald DJ, Italiano Jr. JE, Maguire PB. (2013) Canonical Wnt signaling in Megakaryocytes regulates Proplatelet formation. Blood. 121,88-96.
28. Steele BM, Harper MT, Smolenski AP, Alkazemi A, Poole AW, Fitzgerald DJ, Maguire PB (2012) WNT-3a modulates platelet function by regulating small GTPase activity. FEBS Lett. 586:2267-2272.
29. Maguire PB, Steele BM, Fitzgerald DJ (2011) Novel Platelet Signalling Pathways Identified via Proteomics. Current Proteomics. 8: 208-215.
30. Johnston O, Cassidy H, O'Connell S, O'Riordan A, Gallagher W, Maguire PB, Wynne K, Cagney G, Ryan MP, Conlon PJ, McMorrow T (2011). Identification of β2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods. Proteomics Clin Appl. 5:422-431.
31. Ní Áinle F, O’Donnell JS, Johnson JA, Brown L, Gleeson EM, Smith OP, Preston RJ. Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells. J Biol Chem. 2011 Jan 14;286(2):1323-30. doi: 10.1074/jbc.M110.159475. Epub 2010 Nov 2. PMID: 21044954
32. Goodall AH, Burns P , Salles I, Macaulay IC, Jones C, Ardissino D, de Bono B, Bray SL, Deckmyn H, Dudbridge F, Fitzgerald DJ, Garner SF, Gusnanto A, Koch K, Langford C, O’Connor M, Rice CM, van der Schoot E, Stemple D, Stephens J, Trip MD, Samani NJ, Watkins NA, Maguire PB, Ouwehand WH, on behalf of the Bloodomics Consortium (2010) Transcription Profiling in Human Platelets Reveals LRRFIP1 as a Novel Protein Regulating Platelet Function. Blood. 116:4646-4656.
33. Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB. (2009) Canonical WNT signalling negatively regulates platelet function. Proc. Natl. Acad. Sci. USA. 106, 19836-19841.
34. Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD. (2009) Differential stimulation of monocytic cells results in distinct populations of microparticles. J. Thromb. Haem. 7, 1019-1028.
35. Ní Áinle F, Preston RJ, Jenkins PV, Nel HJ, Johnson JA, Smith OP, White B, Fallon PG, O'Donnell JS. Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation. Blood 2009 Aug 20;114(8):1658-65. doi: 10.1182/blood-2009-05-222109. Epub 2009 Jun 16. PMID: 19531655
36. Preston RJ, Tran S, Johnson JA, Ní Áinle F, Harmon S, White B, Smith OP, Jenkins PV, Dahlbäck B, O'Donnell JS. Platelet factor 4 impairs the anticoagulant activity of activated protein C. J Biol Chem. 2009 Feb 27;284(9):5869-75. doi: 10.1074/jbc.M804703200. Epub 2009 Jan 6. PMID: 19129181
37. Harmon S, Preston RJ, Ní Áinle F, Johnson JA, Cunningham MS, Smith OP, White B, O'Donnell JS. Dissociation of activated protein C functions by elimination of protein S cofactor enhancement. J Biol Chem. 2008 Nov 7;283(45):30531-9. doi: 10.1074/jbc.M802338200. Epub 2008 Sep 8. PMID: 18779332
38. Ní Áinle F, Wong A, Appleby N, Byrne B, Regan C, Hassan T, Milner M, Sullivan AO, White B, O'Donnell J. Efficacy and safety of once daily low molecular weight heparin (tinzaparin sodium) in high risk pregnancy. Blood Coagul Fibrinolysis. 2008 Oct;19(7):689-92. doi: 10.1097/MBC.0b013e32830b14ef.
a. PMID: 18832911
39. Behan AT, Foy M, Wynne K, Clarke M, Sullivan M, Cotter DR, Maguire PB. (2008) Analysis of membrane microdomains-associated proteins in the insular cortex of human brain. Proteomics Clinical Applications, 1, 1324-1331.
40. Feighery R, Maguire P, Ryan MR, McMorrow T. (2008) A proteomic approach to immune-mediated epithelial-mesenchymal transition. Proteomics Clinical Applications, 2, 1110-1117.
41. O'Riordan A, Johnston O, McMorrow T, Wynne K, Maguire P, Hegarty J, McCormick A, Watson AJ, Cagney G, Gallagher WM, Ryan MR. (2008) Identification of Apolipoprotein AI as a serum biomarker of chronic kidney disease in liver transplant recipients, using proteomic techniques. Proteomics Clinical Applications, 2, 1338-1348.
42. Kerrigan SW, Jakubovics NS, Keane C, Maguire P, Wynne K, Jenkinson HF, Cox D. (2007) Role of Streptococcus gordonii surface proteins SspA/SspB and Hsa in platelet function. Infect Immun. 75, 5740-5747.
43. Coppinger JA, O'Connor RI, Wynne K, Flanagan M, Sullivan M, Maguire PB, Fitzgerald DJ, Cagney G. (2007) Moderation of the platelet releasate response by aspirin. Blood. 109, 4786-92.
44. Foy M. & Maguire PB. (2007) Recent advances in the characterisation of the platelet membrane system in platelets. Curr. Pharm. Des. 13, 2647-2655.
45. Coppinger JC & Maguire PB. (2007). Insights into the platelet releasate. Curr Pharm Des. 13, 2640-2646.
46. Maguire PB, Belton O, O’Donoghue N & Coppinger JC. (2007) “Platelet-endothelial interactions” in, The Endothelium: A Comprehensive Reference. Edited by William C. Aird. Cambridge Univerity Press, Cambridge, UK.
47. Foy M., Harney D.F, Wynne K.J & Maguire PB (2007) Enrichment of phospho-tyrosine proteome of human platelets by immunoprecipitation. Methods Mol. Biol. 357, 313-318.
48. Coppinger JC, Fitzgerald DJ & Maguire PB (2007) Analysis of the platelet releasate. Methods Mol. Biol. 357, 307-312.
49. Kelly P, Maguire PB, Bennett M, Fitzgerald DJ, Edwards R, Thiede B, Treumann A, Collins J, O'Sullivan GC, Shanahan F, Dunne C. (2005) Correlation of probiotic Lactobacillus salivarius growth phase with its cell wall-associated proteome. FEMS Microbiol. Lett. 252, 153-159.
50. Maguire PB, Foy M & Fitzgerald DJ (2005) Using proteomics to identify potential therapeutic targets in platelets. Biochem. Soc. Trans. 33, 409-412.
51. Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond J, Cahill D, Emili A, Fitzgerald DJ & Maguire PB. (2004) Proteomic characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood. 103, 2096-2104.
52. Maguire PB. (2004) Platelet proteomics: identification of potential therapeutic targets. Pathophysiol. Haemost. Thromb. 33(5-6):481-6.
53. Maguire PB, Moran N, Cagney G & Fitzgerald DJ. (2004) Application of proteomics to the study of platelet regulatory mechanisms. Trends Cardiovasc. Med. 14(6):207-20.
54. McRedmond J, Park S, Reilly D, Coppinger JA, Maguire PB, Shields D, Fitzgerald DJ. (2004) Integration of transcriptomics and genomics in platelets: a profile of platelet proteins and platelet-specific genes. Mol. Cell. Proteomics. 3, 133-144.
55. Maguire PB & Fitzgerald DJ. (2003) Platelet proteomics. J. Thromb. Haemost. 1, 1593-1601.
56. Maguire PB, Wynne KJ, & Fitzgerald DJ. (2002). The phosphotyrosine proteome isolated from human platelets. Bioforum International, 6, 326-327.
57. Maguire PB, Wynne KJ, Harney DF, O’Donoghue NM, Stephens G, Fitzgerald DJ (2002) Identification of the phosphotyrosine proteome from thrombin activated platelets. Proteomics, 2, 642-648.
58. Ohlendieck K, Froemming GR, Murray BE, Maguire PB, Leisner E, Traub I & Pette D. (1999). Effects of chronic low-frequency stimulation on Ca2+-regulatory membrane proteins in rabbit fast muscle. Pflugers Arch, Eur. J. Physiol. 438, 700-708.
59. Culligan K, Mackey A, Finn D, Maguire PB & Ohlendieck K. (1998) Role of dystrophin isoforms and associated proteins in muscular dystrophy (review). Int. J. Mol. Med. 2, 639-648.
60. Murray B. E., Froemming G. R., Maguire P. B. & Ohlendieck K. (1998) Excitation-contraction-relaxation cycle: role of Ca2+-regulatory membrane proteins in normal, stimulated and pathological skeletal muscle (review). Int. J. Mol. Med. 1, 677-687.
61. Maguire P. B., Briggs F. N., Lennon N. & Ohlendieck K. (1997) Oligomerization is an intrinsic property of calsequestrin in normal and transformed skeletal muscle. Biochem. Biophys. Res. Comm. 240, 721-727.
62. Maguire P.B. & Ohlendieck K. (1996) Oligomerization of sarcoplasmic reticulum Ca2+-ATPase from rabbit skeletal muscle. FEBS Lett. 396, 115 -118.

Conference Proceedings

Recent International Oral Presentations

  1. O’Shaughnessy F, Kehoe B, Archer D, Carvell S, Garvan G, Donnelly J, Cooley S, Ní Áinle F, Cleary B Improving safe and appropriate anticoagulant use through electronic health record integration: A proof of concept. Oral Presentation, UK Health Services Research & Pharmacy Practice Conference Newcastle, April 12th and 13th 2018
  2. Bistervels I, Buchmuller A, Bleker S, Chauleur C, Ní Ainle F, Donnelly J, Verhamme P, Jacobsen AF, Decousus H, Middeldorp S. Induced Delivery and Neuraxial Anesthesia in Pregnant Women Using Thromboprophylaxis: Data from the Highlow Study. Oral presentation and Young Investigator Award, XXVI Congress of the International Society on Thrombosis and Haemostasis, Berlin, Germany, July 2017.
  3. O’Shaughnessy F, Bennett K, Ní Áinle F, Cleary B. VTE risk factors in an Irish Urban Obstetric Population. Oral presentation and Young Investigator Award, XXVI Congress of the International Society on Thrombosis and Haemostasis, Berlin, Germany, July 2017.
  4. Szklanna PB, Parsons MEM, Wynne K, O’Connor H, Egan K, Ní Áinle F, Maguire P. The Platelet releasate is a ‘barcode’ for the health status of an individual. Oral presentation, XXVI Congress of the International Society on Thrombosis and Haemostasis, Berlin, Germany, July 2017.
  5. Kevane B, Egan K, Allen S, Maguire P, Neary E, Lennon A, Ní Áinle F. Endothelial protective properties of low molecular weight heparin (LMWH) Tinzaparin in combination with statin: a novel potential therapeutic tool in preventing cancer metastasis? Oral Presentation, 58th Annual Meeting and Exposition of American Society of Haematology (December 3-6, 2016) San Diego, CA
  6. Cooley S, Donnelly JC, Deering M, Raman A, O’Reilly M, Gannon G, Holland A, O’Shaughnessy F, Brady M, Hayes N, Ní Áinle F, Cleary B. Thrombocalc: Personalized postpartum VTE risk assessment in a high-throughput environment. Oral presentation, Society for Maternal-Fetal Medicine Annual Meeting, Atlanta, GA, February 2016
  7. Neary E, McCallion N, Kevane B, Egan K, Cotter M, Ní Áinle F. The anticoagulant action of activated protein C in very preterm infants. Oral poster presentation, Joint European Neonatal Societies Congress, Budapest, Sept 2015
  8. Egan K, DillonA, Galvin Z, Kevane B, Neary E, Stewart S, Ní Áinle F (presented by Fionnuala Ní Áinle). Thrombin generation varies with fibrosis score in patients with well-compensated liver cirrhosis of mixed aetiology. Oral presentation, International Society on Thrombosis and Haemostasis Congress, Toronto, June 20-25, 2015
  9. Maguire PB, Dervin F, Dempsey E, Bennett C, Guerrero J, Ghevaert C. Platelet exosomes, plexosomes, are targeted to platelet alpha-granules and can modulate canonical WNT signalling in target cells. Oral Presentation & Young Investigator Award to Dr Maguire, International Society of Extracellular Vesicle (ISEV) meeting (23-26 Apr 2015) in Washington DC
  10. D.P. Mitchell, M. Rowan, M. Crockett, F. Ni Ainle, P. Mac Mahon CTPA bolus timing techniques in pregnancy: an underappreciated contributor to breast radiation dose. European Congress of Radiology, Vienna, March 2015

Recent International Poster Presentations

  1. O’Shaughnessy, Donnelly J, Cooley S, Bennett K, Ní Ainle F, Cleary B. Initiating postpartum pharmacological thromboprophylaxis: A comparison of international recommendations. Poster Presentation, 38th Annual Meeting of the Society for Maternal-Fetal Medicine, Dallas, Texas, January 2018
  2. Angelov D, Egan K, Ní Áinle F. Characterization of platelet activation markers in early onset preeclampsia. 22nd Congress of the European Haematology Association, June 2017, Madrid, Spain
  3. Allen S, Okigbo S, Egan K, Al Zadjali A, Kenny D, Maguire P, Kevane B, Ní Áinle F, Thakore J. Thrombin Generation in Schizophrenia Patients Treated with Antipsychotic Medications. Poster presentation, XXVI Congress of the International Society on Thrombosis and Haemostasis, Berlin, Germany, July 2017.
  4. McKinnon T, O’Connor H, Kevane B, Donnelly J, Monteith C, Maguire P, Szklanna P, Allen S, Ní Áinle F. VWF and ADAMTS13 Levels in Early Onset Preeclampsia: Prothrombotic Mechanisms in Mothers with Elevated Risk of Venous Thromboembolism. Poster presentation, XXVI Congress of the International Society on Thrombosis and Haemostasis, Berlin, Germany, July 2017.
  5. Egan K, O’Connor H, Monteith C, Palmar K, Tully E, Kevane B, Malone F, Dunne E, Kenny D, Maguire P, Allen S, McCallion N, Hunt B, Ní Áinle F. Attenuated thrombin generation and enhanced fibrinolytic activity in early onset preeclampsia. Poster presentation, XXVI Congress of the International Society on Thrombosis and Haemostasis, Berlin, Germany, July 2017.
  6. Bistervels I, Buchmuller A, Bleker S, Chauleur C, Ní Ainle F, Donnelly J, Verhamme P, Flem Jacobsen A, Décousus H, Middeldorp, S. for the Highlow investigators. Neuraxial anesthesia in pregnant women using thrombosis prophylaxis: data from the Highlow study. 7th International Symposium on Women's Health Issues in Thrombosis and Haemostasis; March 3-5, 2017, Barcelona, Spain.
  7. Bleker SM, Bistervels MI, Buchmuller A, Chauleur C, Ní Áinle F, Donnelly J, Verhamme P, Flem Jacobsen A, Decousus H, Middeldorp, S. Interim Report of the Highlow Study: A Randomized Controlled Trial Comparing Two Doses of Low Molecular Weight Heparin for the Prevention of Pregnancy-Associated Recurrent Venous Thromboembolism Poster Presentation, 58th Annual Meeting and Exposition of American Society of Haematology (December 3-6, 2016) San Diego, CA
  8. Kevane B, Allen S, Walsh K, Egan K, Maguire PB, Kenny D, Crawford S, Savage R, Doran E, Lennon A, Neary E, Ní Áinle F. A novel beneficial role for Macitentan in patients at high thrombosis risk: attenuation of platelet-mediated derangements of blood coagulation in Eisenmenger syndrome. Poster Presentation, 58th Annual Meeting and Exposition of American Society of Haematology (December 3-6, 2016) San Diego, CA
  9. Egan K, O’Connor H, Kevane B, Malone F, Al Zadjali A, Cooley S, Monteith S, Maguire P, Szklanna PB, Allen S, McCallion N, Ní Áinle F. Tissue Factor Pathway Inhibitor Mediates Attenuation of Tissue Factor-Stimulated Thrombin Generation in Early Onset Preeclampsia. Poster Presentation, 58th Annual Meeting and Exposition of American Society of Haematology (December 3-6, 2016) San Diego, CA
  10. Kevane B, Walsh K, Allen S, Egan K, Szklanna P, Maguire P, Crawford S, Savage R, Doran E, Lennon A, Ní Áinle F. Plasma Thrombin Generation in Platelet-Rich Plasma is Enhanced in Patients with Eisenmenger Syndrome. 15th International Pulmonary Hypertension Forum, Barcelona, 18th-20th March 2016 Barcelona
  11. Parsons, MEM, Szklanna PB, McParland D, O’Connell D, O’Connor H, McGuigan C, Ní Áinle F, Maguire P. Optimal EV measurement in complex biological samples using nanoparticle tracking analysis. 2016 Congress of the International Society for Extracellular Vesicles (ISEV2016), Rotterdam, the Netherlands, 4-7 May 2016.
  12. Egan K, Ma Hui, Kevane B, Lennon A, Allen S, Neary E, Wynne K, O’Shea S, O’Kennedy R, Ní Áinle F. Platelet-derived beta thromboglobulin: a potential novel activator of coagulation factor X. Poster presentation, 57th Annual Meeting of American Society of Hematology, Orlando, Florida 05-08 December, 2015  
  13. Egan K, Dunne E, Dillon A, Kevane B, Galvin Z, Kenny D, Stewart S, Ní Áinle F. Increased soluble GPVI levels in cirrhosis: evidence for collagen induced platelet activation in vivo. Poster presentation, 57th Annual Meeting of American Society of Hematology, Orlando, Florida 05-08 December, 2015
  14. O’Connor H, Egan K, Kevane B Malone F Cooley S, Geary M, Maguire P, Sklanna P, Tully E, Neary E, O’Loughlin J, Allen S, McCallion N, Ní Áinle F. Coagulation balance in early onset preeclampsia (EOP). Poster presentation, Society for Maternal-Fetal Medicine Annual Meeting, Atlanta, GA, February 2016

National Conference Presentations

  1. Szklanna PB, Parsons MEM, Wynne K, O’Connor H, Egan K, Ní Áinle F, Maguire P. The Platelet releasate is a ‘barcode’ for the health status of an individual. UCD Conway Institute Research Festival September 2017 (Oral moderated poster session; Finalist, Innovation award) 
  2. Pathways to thrombosis in early onset preeclampsia: Unravelling molecular mechanisms to understand risk. Karl Egan, Hugh O’Connor, Barry Kevane, Fergal Malone, Amani Al Zadjali, Sharon Cooley, Michael Geary, Patricia Maguire, Paulina Szklanna, Seamus Allen, Naomi McCallion, Fionnuala Ní Áinle. Oral Presentation, HRB KEDS-funded World Thrombosis Day Conference 13/10/2016, Rotunda Hospital Pillar Room (HRB Knowledge Exchange and Dissemination Scheme (KEDS) KEDS-2015-1633)
  3. Barrett A, Kevane B, Hall P, Ní Ainle F, Breslin T. Screening for malignancy in patients with unprovoked venous thromboembolism: a single-centre retrospective case-series. Poster Presentation, Haematology Association of Ireland meeting, October 2016
  4. Kevane B, Allen S, Walsh K, Egan K, Maguire PB, Kenny D, Crawford S, Savage R, Doran E, Lennon A, Neary E, Ní Áinle F. A novel beneficial role for Macitentan in patients at high thrombosis risk: attenuation of platelet-mediated derangements of blood coagulation in Eisenmenger syndrome. Poster Presentation, Haematology Association of Ireland meeting, October 2016
  5. Kevane B, Egan K, Allen S, Maguire P, Neary E, Lennon A, Ní Áinle F. Endothelial protective properties of low molecular weight heparin (LMWH) Tinzaparin in combination with statin: a novel potential therapeutic tool in preventing cancer metastasis? Oral Presentation, Haematology Association of Ireland meeting, October 2016
  6. Pathways to thrombosis in early onset preeclampsia: Unravelling molecular mechanisms to understand risk. Karl Egan, Hugh O’Connor, Barry Kevane, Fergal Malone, Amani Al Zadjali, Sharon Cooley, Michael Geary, Patricia Maguire, Paulina Szklanna, Seamus Allen, Naomi McCallion, Fionnuala Ní Áinle. Poster Presentation, UCD Conway Festival of Research & Innovation 14/09/2016
  7. Pathways to thrombosis in early onset preeclampsia: Unravelling molecular mechanisms to understand risk. Karl Egan, Hugh O’Connor, Barry Kevane, Fergal Malone, Amani Al Zadjali, Sharon Cooley, Michael Geary, Patricia Maguire, Paulina Szklanna, Seamus Allen, Naomi McCallion, Fionnuala Ní Áinle. Oral presentation, Rotunda Hospital Research Day 02/06/2016
  8. Treatment of pregnancy-associated venous thromboembolism with low molecular weight heparin: a retrospective analysis of clinical outcomes before and after discontinuation of routine monitoring of anticoagulant activity using the anti-factor Xa assay. McDonnell B, Glennon K, Kevane B, Donnelly J, Ní Áinle F. Oral Presentation and Finalist, Royal Academy of Medicine in Ireland Registrar’s Prize 11/03/2016
  9. Platelet-derived β-thromboglobulin: a potential novel activator of coagulation factor X. EganK, Hui Ma, Kevane B, Lennon A, Allen S, Neary E, Wynne K, O’Shea S, O’Kennedy R, Ní Áinle F. Oral Presentation, Haematology Association of Ireland Annual Meeting, Galway, October 2015. (Awarded joint first prize for best oral presentation)
  10. Low molecular weight heparin (LMWH) & fractions of LMWH with diminished anticoagulant activity support endothelial barrier function. Kevane B, Egan K, Maguire P, Neary E, Allen S, Lennon Á, Ní Áinle F. Poster Presentation, Haematology Association of Ireland Annual Meeting, Galway, October 2015.
  11. Plasma thrombin generation in platelet-rich plasma is enhanced in patients with Eisenmenger syndrome. Kevane B, Walsh K, Allen S, Egan K, Szklanna P, Maguire P, Savage R, Doran E, Neary E, Ní Ainle F. Poster Presentation, Haematology Association of Ireland Annual Meeting, Galway, October 2015
  12. Platelet-derived β-thromboglobulin: a potential novel activator of coagulation factor X. EganK, Hui Ma, Kevane B, Lennon A, Allen S, Neary E, Wynne K, O’Shea S, O’Kennedy R, Ní Áinle F. UCD Conway Institute Research Festival September 2015 (Oral moderated poster session) 
  13. DillonA, Egan K, Galvin Z, Kevane B, Neary E, Ní Áinle F, Stewart S. Thrombin generation varies with fibrosis score in patients with well-compensated liver cirrhosis of mixed aetiology. Irish Society of Gastroenterology Summer Meeting June 2015, Co Kildare. Awarded First Prize for Best Poster

Recent News

Launch of SPHERE; a New UCD-based Vascular Research Group

September 2015
A new UCD-based research group, SPHERE aims to harness unique haematological tools to diagnose and understand a host of inflammatory-based diseases. The officiall launch of SPHERE coincided with the recent VTE Dublin 2015 conference that took place at the Croke Park Conference Centre in Dublin on Friday 18 and Saturday 19 September 2015. Read more>>

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