Conway Fellows (A-Z)


Keywords: Inflammatory bowel disease, epithelial barrier function

My research focuses on epithelial barrier function in the context of inflammatory bowel disease. Our lab is investigating novel signaling molecules that promote epithelial cell proliferation and migration or restitution of epithelial cell junctions. Our research is designed to better understand epithelial barrier dysfunction in IBD with the goal of identifying possible novel therapeutic strategies.


Keywords: Host-pathogen interaction, innate immunity, pharmacology, mucosa, epithelium, inflammation.

Epithelial function is studied using a range of technologies. We are interested in the role of other cells (nerves, immune cells, endocrine cells) in the regulation of epithelial function. The same models are used in drug discovery and in the design of drug delivery strategies. We use intact tissues with complex structural organisation to examine the relationship between mammals and microorganisms.

Keywords: hypertension, heart disease, heart failure

My team focus on translational research in heart failure, specifically on the development of prognostic and diagnostic biomarkers and novel therapeutics for diastolic dysfunction. We also investigate therapeutics for pulmonary fibrosis

Keywords: arteriosclerosis, macrophage biology, lipid biology, cardiovascular disease

Our current programme of research investigates the fundamental mechanisms governing atherosclerosis regression. Our laboratory has established a novel model of atherosclerosis regression in vivo, achieved by administration of conjugated linoleic acid (CLA) apoE knockout mouse model of atherosclerosis.

Keywords: Ciliopathies; C elegans model system

We employ genetics, cell biology and advanced imaging approaches to investigate the molecular basis of cilium formation and function. These microtubule based organelles extending from the surfaces of most eukaryotic cell types serve critical functions in cell and fluid motility, chemo-/photo-/mechano- transduction and developmental signalling. Defects in cilium function lead to many human diseases including polycystic kidney disease, retinitis pigmentosa, as well as multisymptomatic disorders such as Bardet-Biedl syndrome.


My main laboratory research interest is in infectious diarrhoeal diseases of childhood and my group focuses particularly on Campylobacter jejuni, a major human intestinal pathogen and the most common cause of bacterial gastroenteritis. We explore the manner in which pathogenicity is modulated by the host but also investigate the role of mucous and mucins in Campylobacter infection.

Keywords: oral delivery, diabetic drugs, oral peptide and macromolecule delivery, intestinal epithelial biology, in vivo pharmacokinetics, intra-articular delivery of anti-arthritic nanoparticles

The science of oral peptide delivery addresses how to convert normally injected biotech peptides and proteins to convenient oral forms for patients, such as oral insulin. However, the problem is that such molecules are unstable in the gut and are poorly absorbed so they require nanoparticle-based technologies to address these issues. We have a range of technologies and bioassays to contribute. We leverage such technologies into other therapeutic areas with unmet needs, such as delivery of nanoparticle-peptides into joints for arthritis.

Keywords: Endometrial, ovarian, cancer, obesity, chemoresistence, immunotherapy

1. Obesity related carcinogenesis: We are using in vitro and in vivo models and also developing trials in patients with early stage endometrial cancer to ascertain if intentional weight loss can change cancer biology. 2. Precision medicine solutions for ovarian cancer: We are using ex vivo diagnostics to improve patient stratification and also develop predictive assays for immunotherapy.

Keywords: Diabetes, Inflammation, Cardiovascular

Diabetes is associated with complications due in part to chronic elevation of blood glucose levels and hypertension, leading to damage of arteries and small blood vessels of the kidney, eye and nervous system. My translationally-focused research objective is the identification of new treatment strategies for arresting the progression of vascular diseases, particularly in the context of diabetes. My investigations use preclinical in vivo models of diabetic (T1D, T2D) complications, novel pro-resolution medicines, micro-RNA therapeutics, clinical biobank specimens, cell model systems.

Keywords: obesity, diet, metabolic syndrome, metabolomics, nutrigenomics

My research interests revolve around metabolism and altered metabolic pathways in health and disease. We currently employ nutrigenomic techniques (metabolomics, proteomics and transcriptomics) to further our understanding of the relationship between nutrition and health. Of particular interest is the development of metabolomics for nutritional research.

Keywords: pathogen genomics, virulence, transcriptomics, microarrays, RNA-seq, evolution

Candida species are among the most common cause of fungal infection worldwide, and have high attributable mortality rates. We work predominantly with C. parapsilosis, which is of particular concern in premature babies and in the old. It grows as biofilms, or living mats, on indwelling medical devices. Biofilms are very resistant to antifungal drugs, making infections difficult to treat. We have identified regulators of biofilm growth that may lead to the development of new therapies.

Keywords: Ovarian cancer, diagnostics, neurodegeneration, Alzheimer's disease, MCI, adaptive immunity

We study proteins and the immune response in patients with auto-immune diseases and cancer. Our aim is to identify patterns of proteins that can be used to better diagnose diseases, which can lead to better treatments and a higher cure rate for patients.

Keywords: host-pathogen interaction, bacterial virulence

My area of interest is how bacteria interact with human and animal tissue and cause disease. The group work with Helicobacter pylori, Campylobacter jejuni and Pseudomonas aeruginosa. An area of particular interest is how bacteria colonise and live in mucus.

Keywords: Inflammatory bowel disease; endocannabinoid pathway; mucosal immunology

My research focuses on the development of novel therapies for the treatment of inflammatory bowel disease. My lab is currently assessing the impact of the endocannabinoid system on mucosal immunology. We have demonstrated a clear role for the endocannabinoid pathway in attenuating intestinal disease and are now working to understand a number of key components of that process.

Keywords: Chronic lung disease pathogenesis, hypoxia, pulmonary vasculature, CXCL11/CXCL12 biological axis

I am interested in understanding the lung specific mechanisms through which hypoxia promotes structural changes in blood vessels and increased blood pressure in chronic lung diseases. Understanding these mechanisms may allow us to identify potential therapeutic strategies so as to target the disease process within the lung without causing unwanted adverse effects in other organs. We seek to identify lung-selective genes and lung-selective microRNAs that contribute to the unique response of the pulmonary vasculature to low oxygen levels.

Keywords: Neurodegeneration, Alzheimer’s disease, dementia, inflammation

My research examines the inflammatory processes in the brain that underlie neurodegenerative diseases, including Alzheimer’s disease and age-related cognitive decline. We assess the impact of the immune system on the brain, in response to lifestyle factors, metabolic disorders and systemic conditions that promote susceptibility to age-related dysfunction. We examine how the endogenous immune system can be manipulated for therapeutic potential, to restore function and alleviate the negative consequences of inflammatory conditions on the brain.

Keywords: Inflammation, metabolism

My group are currently looking at the role of NR4A genes in regulating NF-kB signalling in immune cells; the role of NR4A genes in the resolution of inflammation and fibrosis; novel therapeutics, such as BMP-7 mutants and incretin hormones, for the treatment of fibrosis and inflammation.

Keywords: fibrosis, growth factors, signalling matrix

My focus is on the interplay between CCN proteins and the TGF? superfamily in diabetic nephropathy.

Keywords: growth, metabolism

My research interests are focused on a family of insulin growth hormone binding proteins (IGFBPs) which regulate IGF bioavailability and thus bioactivity. Reduced IGF-I bioavailability is a feature of type 1 and type 2 diabetes and there is growing evidence that this is an important factor in the pathophysiology of these disorders.

Keywords: neuro-endocrinology of reproduction

As part of the Reproductive Biology Research Cluster, we focus on specific aspects of female infertility in order to identify molecules in ovarian follicles, oocytes, embryos and the cervix and uterus that are responsible for, or are markers of, infertility. This is achieved by using established large animals of fertility/infertility, in vitro cell culture techniques and the latest technological advances in the biosciences to study the structure and function of complex molecules.

Keywords: Hypoxia, hyercapnia, cell signalling, inflammation

The focus of our research is how different levels of the physiological gases oxygen and carbon dioxide contribute to cell signalling, particularly in the context of inflammation. Current projects are directed towards understanding the mechanisms underpinning the cellular sensitivity to carbon dioxide and cross talk between oxygen and carbon dioxide signalling pathways.

Keywords: Diabetes, obesity, bariatric, renal

My research efforts are focused on understanding the mechanisms of action of bariatric/metabolic surgery with a special emphasis on attendant impact on renal microvascular complications of diabetes.

Keywords: Spinal cord injury, neuroinflammation, stem cells, immunology, regenerative medicine

Over two million people are affected by spinal cord injury (SCI) worldwide. Following SCI, proinflammatory resident microglia and infiltrating macrophages dominate the pathological environment and can exert beneficial or detrimental effects, depending on their activation state. We aim to understand what drives these activation states in order to modulate the inflammatory response and ultimately improve recovery after SCI.

Keywords: cancer, breast cancer, biomarkers, therapy

Development of new biomarkers and therapeutics for breast cancer


Keywords: pulmonary fibrosis, Ebv infection

Keywords: endothelial cell biology, mesenchymal stem cells, transplant, regenerative medicine

My major research focus is on endothelial pathology in transplant medicine and on mesenchymal stem cells in transplant and regenerative medicine.

Keywords: host-pathogen interaction

As part of the Reproductive Biology Research Cluster, we focus on specific aspects of female infertility in order to identify molecules in ovarian follicles, oocytes, embryos and the cervix and uterus that are responsible for, or are markers of, infertility. This is achieved by using established large animals of fertility/infertility, in vitro cell culture techniques and the latest technological advances in the biosciences to study the structure and function of complex molecules.

Keywords: PPAR-gamma, unsaturated lipid type, natural products, protease inhibitors, anti-angiogenic compounds, natural products, analogues

We are engaged in devising new methods for the chemical synthesis of natural products and their analogues with a view to both inventing and exemplifying new types of chemical reactions and also to investigating the biological activities of the synthesised targets. Targets include fatty acid metabolites and alkaloids with a range of biological effects including anti-inflammatory, anti-angiogenic, cytotoxic and CNS activity


Keywords: Heart & lung transplant pathology, interstitial lung diseases, lung cancer and cardiac/cardiovascular pathology

I provide national expertise in interstitial lung disease and in adult sudden cardiac death, working closely with respiratory consultants and cardiothroacic surgeons. At research levels, I provide expertise in tissue and cell morphology, image analysis, animal models and immunohistochemistry.

Keywords: psoriatic arthritis, synovium, genetics, proteomics

Key research disease area is inflammatory arthritis (IA) in particular psoriatic arthritis. At SVUH, we have built up a large clinical cohort of inflammatory arthritis patients with defined clinical and radiographic phenotype on a longitudinal database. Our bio-resource facilitates the study of disease mechanisms and mode of action of therapeutic interventions.

Keywords: Viruses, One Health approach, hepatitis E

My research focuses on viral infections that can be transmitted from animals to humans, and a One Health approach to understand these diseases. My current research focuses on hepatitis E virus, an emerging viral infection that is of increasing importance as a cause of acute hepatitis in people.


Keywords: functional genomics, molecular diagnostics, in vivo imaging, breast cancer, melanoma, biomarkers, tissue microarrays

The identification and validation of biomarkers of breast cancer and melanoma is a major research focus in our group. Biomarkers act as a signature for a specific disease and are used to develop diagnostic tests, enable more targeted treatment strategies and can provide rapid information on the effectiveness of cancer treatment.

Keywords: drug development, protide drugs, nucleoside drugs, novel sugars

Nucleosides are an important drug class that includes some well-known anti-viral and anti-cancer drugs such as Zovirax (cold sores), AZT (HIV) and Gemzar (anti-cancer). There is a limitation on the development of such drugs as their activation within the target cells in the body often is not very efficient. We discovered an easy way to make phosphorus compounds for use in the structure of ‘ProTide’ drugs to enable the self-activation of these nucleosides.

Keywords: Cingulate cortex, MRI, insulin, GABA, cerebellum, behaviour, operant conditioning, learning, conduct disorder, obsessive compulsive disorder, autism, psychopathy, type 1 myotonic dystrophy, diabetes.

Research is directed towards the neuroscience of rule making and breaking. This employs neuropsychology in combination with brain MRI, neurophysiology and transcriptomic metrics in coordinated mouse and human clinical and population cohorts. Unwillingness to change strategy and rule learning may involve insulin, immune and GABAergic related mechanisms as key elements.

Keywords: diabetic kidney disease, resolution of inflammation, diabetic complications, macrophages, signal transduction, gene expression

Our focus is on the molecular mechanisms underlying the initiation, progression and potential regression of diabetic kidney disease; genome wide association study of diabetic kidney disease and lipoxins and lipoxin stable analogues as modulators of inflammatory arthritis


My research interests are in the application of genomic technologies as a route to improved understanding of disease and the exploitation of this knowledge for improved control tools. Current research focuses on improved diagnostics for bovine tuberculosis and Johne's disease.


My research focuses on advanced hyperspectral chemical imaging techniques combined with chemometrics and molecular dynamics simulations to uncover new knowledge on biodegradation, biofouling and biocompatibility of biomaterials. We use Raman chemical imaging and chemometrics to objectively assess prostate tissue, investigate microbial growth in food matrices and surfaces using hyperspectral imaging across different spatial and spectral modalities.

Keywords: autism, genetic predisposition to breast cancer, inherited conditions in Irish Travellers, ethics in paediatric and genetic research

Research interests focus on the application of modern genetic technology in a range of clinical conditions, including inherited neurological disease and cancer as well as ethical aspects of research in paediatrics and in genetics.

Keywords: lipoxins and thromboxane inhibitors, synthetic organic chemistry, asymmetric synthesis, total synthesis, inflammation, neurochemistry

Our research group focuses on synthetic organic chemistry and the ability to synthesise molecules with a range of properties. In our work on inflammation, we prepare stable lipoxin analogues with an active region for biological activity but which resist, or more slowly undergo metabolism and have a longer pharmacological activity. We also have a long-standing interest in the chemistry and biology of amphetamines and substituted MDMA analogues.


Keywords: depression, sickness behaviour, neurotransmitter transporters

Understanding function and regulation of the serotonin transporter (SERT), a neurotransmitter transporter implicated in various mood and behavioural disorders and a key target of currently prescribed antidepressants. We are also interested in peripheral functions such as during platelet activation.

Keywords: Childhood cancer, neuroblastoma, MYCN, cancer biology, cell signalling, proteomics.

Malignancies arising in children are rare; and differ from cancers developing in adults. However, treatment regimens for children often consist of drugs used to treat adult cancers; and current therapies are associated with long-term side effects in children. My group aims to identify less toxic and better personalised therapies for children with cancer. In particular, we focus on highly aggressive childhood cancers which are driven by the ‘undruggable’ MYCN or MYC transcription factors, such as neuroblastoma (NB) and Burkitt’s lymphoma (BL), respectively.

Keywords: structural biology, diabetes, obesity, NMR spectroscopy

Our group is currently working on several research projects to look at the various ways to develop new drugs and alternative therapy in treatment of diabetes and other human diseases.

Keywords: Hypoxia, Inflammation, Fibrosis, Biomarker, Chronic Kidney Disease, Diabetes, Hypertension

my research has focussed intensively on the molecular processes which are altered in diseased kidneys. My studies have identified hypoxia, or insufficient oxygen, as a critical micro-environment which controls both pro-inflammatory and pro-fibrotic processes which are fundamental to kidney disease progression. I am currently examining how hypoxia-regulated pathways may be exploited in an effort to develop novel diagnostic and treatment strategies for DN. This research employs a variety of pre-clinical models of kidney disease along with analysis of CKD patient samples.

Keywords: Cancer epidemiology, molecular epidemiology, nutrition, genetics, microbiome, gastrointestinal cancer

My current research in molecular epidemiology examines how nutritional, genetic, metabolic, microbial and lifestyle factors (together with their interactive impact on molecular mechanisms) may affect the initiation and progression of cancer, including colorectal cancer (CRC; area of most focus), and also current projects in liver, pancreatic, breast, and gastric cancer. Investigative approaches include nutritional, genetic, molecular and microbial epidemiology observational and experimental studies in large European cancer cohorts.

Keywords: Long noncoding RNAs; LncRNAs; Cancer; Lung Cancer; CRISPR-Cas9; genome editing; bioinformatics; genomics.

The human genome produces tens of thousands of enigmatic RNA transcripts that do not encode protein: “long noncoding RNAs” (lncRNAs). Our lab employs an interdisciplinary mixture of bioinformatics and CRISPR-Cas9 genome editing to identify lncRNAs underpinning cancer and eventually target them therapeutically.


Keywords: remodelling, fibrosis, lung, angiogenesis

Cytokines in lung injury and remodelling

Keywords: neurodegeneration, neurotherapeutics, neurogenetics, visual function, anti-angiogenetic drugs, developmental and pathological angiogenesis

We focus on genetic pathways and the pharmacological agents that modulate visual function and disease. We use genetic approaches to identify genes and pathways that mediate eye development, development of visual function and cone photoreceptor function. In parallel, we apply random and targeted small molecule drug screens to identify novel compounds that inhibit intraocular angiogenesis in the eye or drugs that modulate vision function in vivo.

Keywords: systems medicine, network fragilities, therapeutical targets, drug combinations

My group employs systems biology driven discovery and validation approaches to develop quantitative, dynamic models of signalling and gene networks that control cellular responses to external cues and thereby cell fate decisions

Keywords: PTO, vascular haematosis, cardiovascular mechanisms

We aim to elucidate the molecular mechanisms of prostanoid-mediated intracellular signalling and of the factors regulating the transcriptional expression of the TP and IP genes with the objective of obtaining a detailed understanding of TXA2- and prostacyclin-regulated haemostasis and vascular tone as well as their contribution to cardiovascular disease.

Keywords: host-pathogen interaction, innate immunity

Reactive oxygen species (ROS) play a crucial role in the host immune defence towards pathogens. We use using 3D cellular systems and/or in vivo models in order to gain a better understanding of the interaction between the immune system and pathogens. A current focus is on the complex relationship between mucosal host defence and bacteria that links signalling networks and functional changes in both in an intricate manner.

Keywords: signal transduction, systems biology, proteomics, cancer biology

My research is focused across three areas: MAPK signalling, proteomics, and cancer research, especially in regard to using systems biology approaches.

Keywords: Cardiovascular, diabetes, regenerative medicine, medical devices, preclinical pharmacology

I have successfully directed several projects in preclinical / clinical pharmacology, specifically in cardiovascular pathophysiology, diabetic complications, medical devices, arthritis, and regenerative medicine, which has resulted in either patentable products and/or high impact publications.


Keywords: Commensal microbiota, chronic inflammatory disorders, respiratory symbionts, pathogenic immune cells

Our research focuses on T cell orchestration of chronic inflammatory disease and the impact of the airway microbiome on pathogenic mechanisms of disease, both within the respiratory tract and systemically.


I have shown that early diabetic kidney disease (DKD) in obese patients can be reversed by Roux-en-Y gastric bypass (RYGB) surgery. Understanding the underlying mechanisms of such reversal will provide vital clues for innovative therapies and biomarkers of DKD regression/progression.

Keywords: growth cone guidance, bionanoscience, single molecule measurements, microfabrication, biosensing, phage display, nanoparticles

My group works in the emerging field of bionanotechnology, primarily focused on the study of intra- and intermolecular forces in biological molecules responsible for the rich structural and functional behaviour of biological systems; and the synthesis of functional materials that are composed of biomolecules conjugated to nanoparticles.


As part of the Reproductive Biology Research Cluster, we focus on specific aspects of female infertility in order to identify molecules in ovarian follicles, oocytes, embryos and the cervix and uterus that are responsible for, or are markers of, infertility. This is achieved by using established large animals of fertility/infertility, in vitro cell culture techniques and the latest technological advances in the biosciences to study the structure and function of complex molecules.


Keywords: host-pathogen interaction, innate immunity

My research activities include functional genomics and systems biology of host/pathogen interactions in domestic animals, with a specific focus on mycobacterial diseases; genomic imprinting and economically important traits in livestock; evolutionary origins and population genetics of domestic cattle; genome mapping in domestic animal species; equine genomics; and application of genomics to commercial animal breeding and food production.

Keywords: platelets, megakaryocytes, cardiovascular disease, atherosclerosis, proteomics

We discovered new signalling machinery in platelets, termed WNT signalling, and can demonstrate that activation of a distinct subset of this machinery can negatively control platelet function. We now aim to investigate how the full complement of WNT machinery regulates platelet activity.


Clinical genetics of mood and psychiatric disorders

Keywords: cell death, cell division, mitosis, anti-mitotic agents

Our research is focused on further understanding the molecular mechanisms of cell division and cell death and how crosstalk between these distinct processes regulates cell fate. We are examining the precise role of mitotic kinases and phosphatases as key upstream regulators of cell death.

Keywords: pregnancy, fetal medicine, diabetes, ultrasound, fetal cardiology, nutrition

Key research areas are 1) Diabetes in pregnancy; research into the effect on mother and baby of pre pregnancy diabetes and of gestational diabetes 2) Nutrition in pregnancy; examination of the impact of maternal nutrition on maternal health and infant health 3)Ultrasound imaging in pregnancy; expanding the diagnostic role of ultrasound in its assessment of fetal health and fetal growth

Keywords: chemoresistance, epigenetic reprogramming in hypoxia, miRNA targeting and regulation, senescence, autophagy

My research interests focus on the mechanisms underlying Paclitaxel chemoresistance for patients presenting with epithelial ovarian cancer and breast cancer, specifically triple negative breast cancer. I also focus on how DNA methylation and histone modifications are altered in hypoxia and how this relates to ultimate chemoresistance and retention of cellular viability in the face of chemotherapeutic engagement.

Keywords: Epithelial cells, chronic infection, cystic fibrosis, vaccine development

My research focuses on 1. Chronic respiratory infection, specifically pathogens that cause opportunistic infections in cystic fibrosis patients, including Burkholderia cepacia complex and P. aeruginosa 2. Vaccine development: we identified a number of bacterial adhesins using a proteomic approach, which showed potential vaccine candidates. 3. Host responses of epithelial cells; mechanisms of pathogenesis; mechanisms of bacterial adaptation during chronic colonisation.

Keywords: obesity, high-density lipoprotein (HDL) function, reverse cholesterol transport, inflammation, hepatosteatosis and diet

I am interested in the impact of obesity and inflammation on HDL function and cardiovascular health. A key goal of this research is to establish the effects of the obesigenic environment on the capacity of macrophages to mediate cholesterol efflux to HDL particles.

Keywords: cystic fibrosis, genetic epidemiology, clinical epidemiology

Keywords: lung disease, hypoxia, pulmonary hypertension, angiogenesis, acute lung injury

My research group is focused on the exploration and understanding of key mechanisms in the development and progression of lung diseases. We aim to identify potential therapeutic strategies that can be used to target the disease process within the lung without causing unwanted adverse effects in other organs.


My group works in the area of prion related disorders that affect both animals and humans and share similarities with Alzheimer’s disease (AD). Abnormal processing of a disease associated endogenous protein is found in both systems. We are investigating the link between the prion protein and AD and also processes to eliminate prion associated disorders through the development of new decontaminants.

Keywords: kidney disease, toxicology, cell signalling, biomarker identification and analysis

Our research focus is to investigate some of the causes of kidney disease. We have identified a number of proteins that malfunction during the development of kidney disease and are investigating the importance of these proteins in causing disease so as to identify novel early biomarkers and potential therapeutic strategies.

Keywords: metabolic disease, obesity, hypoxia

Sleep apnoea

Keywords: host-pathogen interaction, innate immunity, vaccine and drug development, diagnostics

Research in my group focuses on three areas: water quality, animal reproduction and foal pneumonia. The facultative intracellular pathogen Rhodococcus equi has many physiological and pathological similarities to the related pathogen Mycobacterium tuberculosis.

Keywords: host-pathogen interaction, innate immunity, vaccine and drug development, immunomodulation, co-infection

My research group focuses on host-pathogen interactions, and is actively involved in understanding how helminths interfere with protective immunity to bacterial infections.

Keywords: neurotherapeutics, learning and memory, synaptic plasticity, transcription control, schizophrenia, multiple sclerosis, neuroinflammation

Our research group is dedicated to the identification of novel drug targets for the treatment of age-related neurological and neurodegenerative diseases such as schizophrenia, depression, Alzheimer’s disease and multiple sclerosis.

Keywords: Diabetes, renal pathophysiology, chemoresistance, cancer biology, fibrogenesis, stenosis, biomarkers

The focus of my research is the identification and functional characterisation of novel therapeutic targets with the aim of developing improved therapeutics and diagnostics for fibrotic disease (including diabetic kidney disease) and more recently for cancer.

Keywords: Haemostasis, thrombosis, vascular biology, maternal health, cancer metastasis

My principal research focus is to investigate the role of coagulation and inflammation in human disease, particularly in disorders affecting maternal health. Current funded projects include investigating coagulation activation in early onset preeclampsia, a disorder associated with maternal and fetal morbidity and mortality; and optimising low molecular weight heparin (LMWH) endothelial protective properties in an effort to identify novel prevention strategies in cancer metastasis.


Keywords: high content imaging, predictive toxicology, cardiac biomarkers

We have invented and validated a predictive cell-based assay for screening drug candidates for their risk of producing idiosyncratic hepatotoxicity and various other toxicities. We are further developing this method to enhance its user-friendliness and predictive effectiveness as well as adapting it for use in detection of on-going toxicity in vivo.

Keywords: medical devices, microfluidic devices, cell biomechanics

I am interested in working with clinicians and scientists to identify clinical needs and develop appropriate solutions with a strategic focus on targeted, minimally invasive delivery of next-generation therapeutics

Keywords: neuroimmune biology, neurotransmission, neurodegeneration, stroke, hypoxia, neurophysiology

My group are interested in neuron to neuron signalling in the brain and how the immune system interacts with this. We are particularly interested in how pro inflammatory molecules modulate synaptic plasticity (a model for memory formation) before and during hypoxic insults to neurons. We are currently investigating how neurons adapt to acute hypoxic exposure.


My research work uses bacteria and their enzymes to develop green technologies for polymer and chemical production.

Keywords: host-pathogen interaction, virulence gene regulation, Campylobacter, gene regulation, infection biology, pathogenesis, transcription

My group focus on discovering how microorganisms respond to changes in their environment and in particular how they alter their gene expression to cause disease under certain conditions. Much of our work is concentrated on studying the food borne pathogen Campylobacter jejuni.

Keywords: obesity

The gut hormone regulation of innate immunity and innate immune cell regulation of weight in adult and paediatric obesity

Keywords: Cell cycle regulation, oocyte quality, biomarkers, cryopreservation

My research focuses on understanding the factors affecting oocyte quality at a molecular level and identifying biomarkers of same. We use model systems including Xenopus laevis, bovine and human. We assess at a molecular level the effect ovarian tissue cryopreservation has on ovarian tissue, follicles and oocytes; in addition to developing a method of culturing primordial follicles and oocytes in vitro. We are also interested in cell cycle regulation and cell checkpoints, particularly the DNA damage checkpoint.

Keywords: Models of neurodegeneration; cell biology

Research in my lab aims to uncover the role of the smooth ER in neurons and how disruption of this organelle, brought about by disease-causing variants in ER-shaping proteins, gives rise to neurodegeneration. By generating novel in-vivo and in-vitro model systems, we aim to better understand the functions of genes underpinning inherited neurodegenerative diseases.

Keywords: host-pathogen interaction, innate immunity, vaccine and drug development

Syntheses of biologically active oligosaccharides and glycoconjugates and development of methods to facilitate these syntheses. Both human, plant and microbial carbohydrate are of interest and synthesised. Biological applications are as antibiotics or vaccines.


Keywords: Proteomics, prostate cancer, psoriatic arthritis, biomarker discovery, biomarker evaluation, radiation therapy, patient engagement

Current interests and funded projects focus on the discovery, measurement and evaluation of protein biomarkers. We aim to progress protein biomarkers from discovery to clinical utility in the areas of oncology and inflammatory disease. We also investigate mechanisms of disease progression focusing on prostate cancer and psoriatic arthritis. We have recently used LC-MS/MS methods to characterise protein expression in discrete regions of prostate tumour following isolation of tumour tissue material by laser capture micro dissection.

Keywords: Cancer, epigenetics, prostate cancer, DNA methylation, biomarkers, urine, liquid biopsies

My research interests are focused on translational prostate cancer epigenetics; understanding the role of epigenomic aberrations in the pathogenesis of prostate cancer and harnessing these aberrations to develop prognostic and predictive biomarkers. My group has a particular interest in studying DNA methylation changes in the prostate gland and in 'liquid biopsies' that can act as surrogates for non-invasive tumour detection and monitoring.

Keywords: synthesis, spectroscopy, organometallics, bioorganometallics, anticancer, antibacterial, computational.

My research interests are in the development of sustainable catalytic processes utilising natural products; energy related catalysis, especially in the area of hydrogen storage from ammonia boranes; pioneering new multifunctional anticancer compounds with enhanced selectivity and inhibitor delivery; development of silver antibiotic drugs with biofilm inhibitor behaviour and activity against MRSA bacteria.

Keywords: Cancer biology, precision medicine, targeted therapies, mechanisms of disease, therapeutic intervention, transcription factors, biomarkers, breast, prostate.

My studies combine in vitro techniques necessary to understand the molecular mechanisms behind chemoresistance with robust patient validation. This integrated translational approach will contribute to the better understanding of the mechanisms of anti-AR therapy resistance in the clinical setting, leading to better and more efficient therapies in both breast and prostate cancer. Importantly, the availability of small-molecule inhibitors for our targets of interest can potentially lead to rapid translation into the clinic.


Keywords: High-throughput biology, Hypoxia- inducible factors, Hypoxic cancer pathobiology, Hypoxic transcriptomics, Hypoxia (physiology & pathophysiology), Oxygen sensing in cancer, Targeted oncology

We are interested in delineating novel, non-canonical as well as canonical hypoxia- inducible factor (HIF)-α dependent mechanisms of oxygen sensing in cancer. To accomplish this goal, we utilize classical molecular and transcriptomic approaches in combination with top-down statistical modeling and high throughput transcriptomic analyses, both in vitro and in vivo.

Keywords: Blindness, therapy, pathophysiology, toxicology, drug discovery, drug development

I work in eye-related research, using zebrafish as a model. I investigate the causes of inherited forms of blindness, I uncover new drugs and develop them as potential therapies for vascular and inflammatory forms of blindness (e.g. age-related macular degeneration or diabetic retinopathy) and dry eye disease. I also have an interest in retinal toxicology, examining drugs to see whether they are toxic in the developing retina.

Keywords: Obesity, Metabolic inflammation, Early life risk factors, Developmental programming, Epigenetics

My current research focus centers on to identification of molecular targets which influence early life risk factors for obesity in offspring born to parents (both mother and father) who are obese or consume a Westernized diet. This work programme will also investigate dietary and exercise based intervention strategies during critical early life time-points (pregnancy, lactation and infancy) to examine the potential for reversal of negative health implications in the offspring.

Keywords: insulin resistance, obesity, nutrition, aging and health, innate inflammation

Our Nutrigenomics Group focuses on the molecular basis of diet induced obesity, insulin resistance and diabetes. There is a strong inflammatory aspect to our work, as we are particularly focused on how dietary/metabolic stressors trigger a pro-inflammatory insulin resistant state.

Keywords: Intermittent hypoxia, obstructive sleep apnoea, cardiovascular disease, inflammation

Our research is focused on the identification of the mechanisms of cardiovascular diseases in obstructive sleep apnoea (OSA). We are specifically interested in inflammatory responses to intermittent hypoxia as the hallmark feature in OSA. Using a translational approach involving cell culture, animal and human studies, we are currently investigating the signalling mechanisms of intermittent hypoxia-induced adipose tissue inflammation and its interaction with obesity.


Keywords: Hypoxia-inducible factors, Hypoxia cancer pathobiology, Metastasis, Hypoxia-dependent lymphangiogenesis & angiogenesis (cancer), Hypoxia-dependent metabolic reprogramming (cancer), Precision medicine

The long-term objective of my research program is to enhance our understanding of the role of hypoxia as an organising molecular principle in cancer pathophysiology, holding the promise of generating knowledge leading to effective treatments, designed to forestall or eradicate the disease.

Keywords: host-pathogen interaction, viruses

My research area is molecular virology and specifically relates to the investigation of the pathogenesis of the human retroviruses human T cell leukemia viruses types 1 and 2. Key focus areas are: 1) Regulation of cellular signalling pathways by HTLV Tax oncogenic proteins 2) Investigation of the pathogenesis of leukemia/lymphoma development in ATLL mouse animal model 3)Characterisation of novel HTLV /cellular protein/protein interactions

Keywords: host-pathogen interaction, microbial toxins, drug delivery, membrane traffic, small GTP binding proteins, membrane traffic, cytoskeleton

My main area of work is focused on gaining a greater understanding of membrane trafficking pathways within mammalian cells, and how they are co-ordinated spatially and temporally. In particular, we are dissecting the molecular machinery responsible for trafficking from the cell surface to organelles of the early secretory pathway, and exploring the use of these pathways for their potential as drug delivery routes.

Keywords: platelets, thrombosis, cell signalling

We are studying the mechanisms of platelet inhibition with the aim of identifying new diagnostic markers of platelet reactivity as well as targets for improved antiplatelet therapy.


Keywords: hypoxia, inflammation

Current research is directed towards expanding our understanding of the mechanisms by which hypoxia regulates transcriptional events in the context of inflammatory disease and cancer. We focus on the regulation of inflammatory gene expression in response to hypoxia and the transcriptional regulators underlying such events particularly in the hypoxia inducible factor and the NF-kappaB pathways.

Keywords: comparative genomics

My research interests lie in the cross-cutting fields of mammalian phylogenetics and comparative genomics, with particular expertise in bat biology.

Keywords: Mechanobiology, Mechanotransduction, Cell mechanics, Biomaterials, Cancer biomechanics, Pancreatic cancer, Stem cell biology, Tissue engineering.

The aim of my research is to leverage fundamental mechanobiology knowledge to direct cell behaviour through specific cell-matrix interactions and biophysical stimulation for regenerative medicine and to disrupt aberrant mechano-signalling in disease.

Keywords: Skin; hair; alopecia; pigmentation, melanogenesis; wound-healing

My research is in the area of basic and applied skin/hair sciences, with a particular focus on the regulation of hair growth in health and disease especially those conditions with an immune-medicated basis, and on the biology of human melanocytes/pigmentation in health and disease.

Keywords: Optogenetics, electrophysiology, memory impairment, movement disorders, gene therapy.

The major target of my work is the treatment of memory and motor impairment in neurodegenerative disorders. My lab uses optogenetic tools in parallel with electrophysiological recordings in the context of rodent spatial behaviour. I aim to apply optogenetics and gene therapy for the treatment of neurodegenerative disorders.


Keywords: angiogenesis, hypoxia, innate and adaptive immunity, drug development

The clinical research focus of our group is early inflammatory arthritis; RA, psoriatic arthritis and related psoriasis.The group has combined high-quality clinical cohort studies with novel arthroscopic and high-end imaging technologies to study synovial tissue in vivo macroscopically, ex vivo and at the cellular and molecular level.


Keywords: Diabetes, obesity, metabolism, metabolic flux analysis, lipidomics, adipose tissue, branched chain amino acids, mass spectrometry

My research is centered around the role of metabolic pathway dysfunction in disease with a focus on obesity. I use stable isotope tracing, mass spectrometry and molecular biology approaches in vitro and in vivo to study this and have a particular interest in de novo lipogenesis and amino acid metabolism.

Keywords: Controlled polymerization; Multivinyl monomers; Knot/cyclized & hyperbranched structures; Injectable hydrogel; Recessive dystrophic epidermolysis bullosa; Non-viral gene delivery; Wound healing

Macromolecular design and engineering via controlled/living polymerisation techniques and click chemistry; Functional nanomaterials - knot and/or dendritic polymers as multifunctional carriers for targeted therapeutic drugs and DNA/RNA delivery; Skin gene therapy and the development of new DNA plasmid vectors; Bio-inspired responsive polymers as dressing/adhesive for wound healing; Injectable ECM biopolymer hybrid hydrogels for stem cells encapsulation and delivery; Biodegradable Medical Device - stent and conduit; Clinical targets: Skin wounds, bone & cartilage, cardiovascular disease

Keywords: Cardiovascular disease; heart failure; diabetes; hypertension; epigenetics; fibrosis; biomarkers

My research is primarily focused on biomarkers, novel therapeutics and unravelling mechanisms of disease (epigenetics) in the areas of diabetes, cardiovascular disease, & global health. Currently based in Queen's University Belfast, I have an adjunct visiting lecturer position with UCD School of Medicine and continue research activities in UCD while holding Associate Conway Fellowship.

Keywords: biomarkers, prostate cancer, targeted agents, hormone therapies, validation, proteomics

My focus of research is in prostate cancer with specific interests in 1) Biomarker discovery and validation for grade and stage of prostate cancer to inform appropriate treatment strategies; 2) Understanding the mechanisms of resistances to therapy of advanced disease.

Keywords: genetic and epigenetic influences in rheumatoid arthritis; ageing and epigenetics; pharmacogenetics of biological therapies

Research focuses on athogenesis of inflammatory musculoskeletal diseases


Keywords: Biochemistry, immunology, immunotherapy, innate immunity, nanoparticles, signal transduction

My group works to understand how immune cells integrate signals at nanoscale with a particular focus on nanoparticle-innate immune interactions. Specifically, we are examining how nanoparticles are recognized and processed by innate immune cells, leading to the induction of cellular immunity. Also we are investigating how and to what extent such interactions can be used to create nanoscale intervention for immunotherapies.


Keywords: carbohydrate chemistry

We develop new methodologies for the synthesis of carbohydrate and glycoconjugates, including development of new glycosylation methods. Also, we are interested in the synthesis of thioglycoside analogues of natural carbohydrates and glycoconjugates .