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The DOMINO-HD study (Multi-Domain Lifestyle Targets for Improving ProgNOsis) is exploring how digital technologies, such as wearable fitness trackers, can be used to support people with Huntington’s disease (HD).


Huntington's disease (HD) is an inherited neurological condition that causes difficulties with movement and coordination. It also causes cognitive impairment that gets worse over time. Symptoms usually develop when people are between 30 and 50 years old and dementia can occur at any stage of the condition. There are currently no treatments for the condition. Current research suggests strong potential for improving quality of life for those living with neurodegenerative diseases, such as HD, with novel health and social care concepts, and innovations focusing on the prevention of dignity, independence and social inclusion. However, the availability and quality of such services vary considerably across Europe and beyond.

The programme is seeking to improve quality of life for people with Huntington's disease. 

DOMINO-HD will focus on aspects of life for people with Huntington's that haven't been studies in depth until now. The researchers will look at how sleep, nutrition and physical activity impact the disease so as to develop new ways to support them to manage these fundamental aspects of their lives. A team in Cardiff University will lead the consortium, with partners in Ireland (UCD), Spain, Poland and Switzerland.

Joint Programme - Neurogenerative Disease (JPND)

DOMINO-HD is part of The Joint Programme – Neurodegenerative Disease (JPND) research awards. The Irish funders are the Health Research Board.

For more information on the project please visit: (opens in a new window)https://www.cardiff.ac.uk/centre-for-trials-research/research/studies-and-trials/view/domino-hd

What is it and why are we doing it?

(opens in a new window)https://eurohuntington.org/2020/10/30/the-domino-hd-study-what-is-it-and-why-are-we-doing-it/