Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity

(27th April 2021) Through a collaborative study between the Godson/Brennan's lab (UCD DCRC), the Perretti's lab (QMUL) and other international colleagues, the work from Silvia Oggero et al., was published, as an Open-Access primary research article, on the prestigious Journal of Extracellular Vesicle (IF, 15) on 27th April 2021 HERE

This work showed the ability of Extracellular Vesicle (EV) to modulate the response of human atherosclerotic plaque, identifying molecular targets of the disease and offering therapeutic avenues for treatment. We also demonstrated the ability of proteomics to identify potential biomarkers of diseases by studying EV. Through the ITN Marie Curie 'Evolution' network, Dr Silvia Oggero has been hosted for six months, between 2018 and 2019, in the Godson/Brennan lab at UCD DRCR, under the direct supervision of Dr Monica de Gaetano, a Senior Postdoc Fellow in the Group.

Dr Oggero specifically carried out, as part of her PhD programme, an ex vivo study on human atherosclerosis, availing of a translational research model recently setup by Dr de Gaetano, accessing post-endarterectomy plaque tissues, in collaboration with a team of vascular surgeons, coordinated by Mrs Mary Barry, Consultant Vascular Surgeon, St Vincent’s University Hospital Dublin.