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AI PREMie

AI_PREMie

The AI PREMie team, led by Professor Patricia Maguire from UCD School of Biomolecular and Biomedical Science, has been awarded €500,000 in recognition of the potential impact of their AI-powered risk stratification platform for preeclampsia. Also from the UCD ConwaySPHERE research group, the team includes Consultant Obstetrician and Gynaecologist Professor Mary Higgins and Consultant Haematologist and Full Clinical Professor Fionnuala Ní Áinle, UCD School of Medicine, and Dr Paulina Szklanna, UCD School of Biomolecular and Biomedical Science

Preeclampsia (PET) is a condition of pregnancy that is difficult to diagnose and kills 50,000 mothers and 500,000 babies globally every year. At present delivery of the pre-term baby is the only treatment and the safest option for the mother. But pre-term delivery can lead to long-term neurodevelopmental problems and even death. ConwaySPHERE is working to develop a new diagnostic test called AI PREMie to better predict PET severity and help save the lives of both mothers and their babies. It is a risk stratification tool that identifies women with PET - and also how the condition will progress. Our AI PREMie tool assesses the pre-eclampsia risk based on circulating biomarkers in the plasma of pregnant mothers. This will give clinicians and other caregivers the opportunity to proactively plan pregnancies for at-risk mothers, giving a clearer understanding if planning for delivery is necessary or if the baby can stay in utero allowing for further development as every day in utero counts.

AI_PREMie Timeline

2017

Elevated plasma TFPI activity causes attenuated TF-dependent thrombin generation in early-onset preeclampsia.

Early onset preeclampsia (EOP) is a pregnancy-specific proinflammatory disorder that is characterised by competing thrombotic and bleeding risks. It was the aim of this study to characterise thrombin generation, a major determinant of thrombotic and bleeding risk, in order to better understand the haemostatic balance in patients with EOP.

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2018

CAPE Study Results

Retrospective secondary analysis of an observational study in an Irish tertiary referral centre with 9000 deliveries annually. The MPV of 27 women with EOPE was compared to 19 unaffected controls. The inclusion criteria for the disease state was the development of EOPE defined by the National Institute for Health and Care Excellence (NICE) guideline, as new onset hypertension presenting after 20 weeks and prior to 34 weeks with significant proteinuria.

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Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults.

Upon activation, platelets release a powerful cocktail of soluble and vesicular signals, collectively termed the "platelet releasate" (PR). Although several studies have used qualitative/quantitative proteomic approaches to characterize PR; with debated content and significant inter-individual variability reported, confident, and reliable insights have been hindered. Using label-free quantitative (LFQ)-proteomics analysis, a reproducible, quantifiable investigation of the 1U mL−1 thrombin-induced PR from 32 healthy adults was conducted.

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The Hundred-Person Platelet Releasate Project.

Upon activation platelets release a host of soluble and vesicular signals, collectively termed the ‘platelet releasate’ (PR). The contents of this PR play a significant role in haemostasis, wound healing, tissue regeneration, inflammation, and pathologic sequelae.

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2019

Science Foundation Ireland Future Innovator Prize

AI for Societal Good Challenge

Supports interdisciplinary teams to develop novel, potentially disruptive AI-based solutions that address significant national and global societal challenges

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The platelet releasate in pregnancy and early-onset preeclampsia. 

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2020

Irish Tech news article

Article in Roller coaster

SAS Viya join the AI-PREMie team

2021

Winner of the NovaUCD Innovation of the Year Award 2021

Siliconrepublic article

Runner up SFI Future Innovator Artificial Intelligence (AI) for Societal Goo

Finalist of Analytics Institute Social Impact Award.

"Using platelets as little health sensors in our blood" - The Irish Times

"Using platelets as little health sensors in our blood" - Recruitment for Technology

Engineers Ireland Article

the pan Canadian thrombotic Research Network

the iPlacenta H2020 virtual conference

Teck Expert Article

Geant Article

HEAnet Article

Science Direct Article

University Observer Interview

AI_PREMie in 2021 AI_Awards Finalists

International Society on Thrombosis and Haemostasis Poster

Research Impact Case Study Competition - runner up

AI_PREMie featured in RTE One in the "Science to the Rescue" show.

AI_PREMie project features in final #TheHealthPulse podcast of 2021 by @SASsoftware

Professor Maguire discusses AI_PREMie on #Allreland podcast

Article by Leaps

Article by Medicalxpress

2022

Professor Patricia Maguire interviewed on Newstalk The Pat Kenny Show discussing AI_PREMie project

AI_PREMie featured in RTE Changemakers

Microsoft recently published an article about AI_PREMie

Read more here:

  1. Irish times on AI_PREMie 
  2. AI_PREMie wins a SFI Innovator Prize
  3. AI_PREMie shortlisted for National Analytics and AI Award 2021
  4. AI_PREMie in Dragon's Den for Scientists
  5. Geant on AI-PREMie
  6. HEAnet on AI-PREMie

AI_PREMie

The AI PREMie team, led by Professor Patricia Maguire from UCD School of Biomolecular and Biomedical Science, has been awarded €500,000 in recognition of the potential impact of their AI-powered risk stratification platform for preeclampsia. Also from the UCD ConwaySPHERE research group, the team includes Consultant Obstetrician and Gynaecologist Professor Mary Higgins and Consultant Haematologist and Full Clinical Professor Fionnuala Ní Áinle, UCD School of Medicine, and Dr Paulina Szklanna, UCD School of Biomolecular and Biomedical Science

Preeclampsia (PET) is a condition of pregnancy that is difficult to diagnose and kills 50,000 mothers and 500,000 babies globally every year. At present delivery of the pre-term baby is the only treatment and the safest option for the mother. But pre-term delivery can lead to long-term neurodevelopmental problems and even death. ConwaySPHERE is working to develop a new diagnostic test called AI PREMie to better predict PET severity and help save the lives of both mothers and their babies. It is a risk stratification tool that identifies women with PET - and also how the condition will progress. Our AI PREMie tool assesses the pre-eclampsia risk based on circulating biomarkers in the plasma of pregnant mothers. This will give clinicians and other caregivers the opportunity to proactively plan pregnancies for at-risk mothers, giving a clearer understanding if planning for delivery is necessary or if the baby can stay in utero allowing for further development as every day in utero counts.

AI_PREMie Timeline

2017

Elevated plasma TFPI activity causes attenuated TF-dependent thrombin generation in early-onset preeclampsia.

2018

CAPE Study Results

Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults.

The Hundred-Person Platelet Releasate Project.

2019

Science Foundation Ireland Future Innovator Prize

The platelet releasate in pregnancy and early-onset preeclampsia. 

2020

Irish Tech news article

Article in Roller coaster

SAS Viya join the AI-PREMie team

2021

Winner of the NovaUCD Innovation of the Year Award 2021

Siliconrepublic article

Runner up SFI Future Innovator Artificial Intelligence (AI) for Societal Goo

Finalist of Analytics Institute Social Impact Award.

"Using platelets as little health sensors in our blood" - The Irish Times

"Using platelets as little health sensors in our blood" - Recruitment for Technology

Engineers Ireland Article

the pan Canadian thrombotic Research Network

the iPlacenta H2020 virtual conference

Teck Expert Article

Geant Article

HEAnet Article

Science Direct Article

University Observer Interview

AI_PREMie in 2021 AI_Awards Finalists

International Society on Thrombosis and Haemostasis Poster

Research Impact Case Study Competition - runner up

AI_PREMie featured in RTE One in the "Science to the Rescue" show.

AI_PREMie project features in final #TheHealthPulse podcast of 2021 by @SASsoftware

Professor Maguire discusses AI_PREMie on #Allreland podcast

Article by Leaps

Article by Medicalxpress

2022

Professor Patricia Maguire interviewed on Newstalk The Pat Kenny Show discussing AI_PREMie project

AI_PREMie featured in RTE Changemakers

Microsoft recently published an article about AI_PREMie

Read more here:

  1. Irish times on AI_PREMie 
  2. AI_PREMie wins a SFI Innovator Prize
  3. AI_PREMie shortlisted for National Analytics and AI Award 2021
  4. AI_PREMie in Dragon's Den for Scientists
  5. Geant on AI-PREMie
  6. HEAnet on AI-PREMie

Contact Conway SPHERE Research Group

UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
T: +353 1 716 6700