Donagh EganPh.D. Student, Kolch/Brennan Groups
Aisling HeeranPostdoctoral Researcher, Kolch/Gomez Matallanas Groups
Luis Iglesias MartinezPostdoctoral Researcher, Kolch Group
Martina KreilederP.h.D. Student, Kolch Group
Aleksandar KrsticSBI Investigator
Myriam NabhanPostdoctoral Researcher, Kolch/Brennan Groups
Rashmi SharmaPostdoctoral Researcher, Kolch/Gomez Matallanas Groups
About the Group
What We Do
The Kolch group is internationally recognised for its cutting-edge research using systems approaches to understand signalling networks. The group uses computational modelling, translational medicine and omics approaches to analyse biological networks with the goal of elucidating the molecular and cellular mechanisms of diseases such as cancer and inflammation (hidradenitis suppurativa, psoriasis, rheumatoid arthritis). The group is also focused on designing new approaches to personalised diagnostics and treatment of diseases based on systems level and molecular mechanistic understanding.
Key Research Highlights
- Pioneered the use of dominant negative mutants to map signalling pathways in mammalian cells
- Development of biochemical high throughput and cellular drug screening assays crucial for the development of two widely used and highly specific PKC inhibitors, Goe6976 and Goe6815
- Discovered mechanisms of crosstalk between protein kinase C and Raf pathways
- Co-discovered the crosstalk between the cAMP and Raf-1 signalling pathways
The Ins and Outs of RAS Effector Complexes.
Biomolecules. 2021 Feb 7;11(2):236. doi: 10.3390/biom11020236.PMID: 33562401
Signaling Dynamics Regulating Crosstalks between T-Cell Activation and Immune Checkpoints.
Trends Cell Biol. 2021 Mar;31(3):224-235. doi: 10.1016/j.tcb.2020.12.001. Epub 2020 Dec 30.PMID: 33388215
Systems biology approaches to macromolecules: the role of dynamic protein assemblies in information processing.
Curr Opin Struct Biol. 2021 Apr;67:61-68. doi: 10.1016/j.sbi.2020.09.007. Epub 2020 Oct 24.PMID: 33126139
Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity.
Int J Mol Sci. 2020 Feb 7;21(3):1102. doi: 10.3390/ijms21031102.PMID: 32046099
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Nat Commun. 2020 Jan 24;11(1):499. doi: 10.1038/s41467-019-14224-9.PMID: 31980649