Group Members

Walter Kolch
Director
Donagh Egan
Ph.D. Student, Kolch/Brennan Groups
Aisling Heeran
Postdoctoral Researcher, Kolch/Gomez Matallanas Groups
Luis Iglesias Martinez
Postdoctoral Researcher, Kolch Group
Martina Kreileder
P.h.D. Student, Kolch Group
Aleksandar Krstic
SBI Investigator
Myriam Nabhan
Postdoctoral Researcher, Kolch/Brennan Groups
Rashmi Sharma
Postdoctoral Researcher, Kolch/Gomez Matallanas Groups

About the Group

What We Do

The Kolch group is internationally recognised for its cutting-edge research using systems approaches to understand signalling networks. The group uses computational modelling, translational medicine and omics approaches to analyse biological networks with the goal of elucidating the molecular and cellular mechanisms of diseases such as cancer and inflammation (hidradenitis suppurativa, psoriasis, rheumatoid arthritis). The group is also focused on designing new approaches to personalised diagnostics and treatment of diseases based on systems level and molecular mechanistic understanding. 

Key Research Highlights 

  • Pioneered the use of dominant negative mutants to map signalling pathways in mammalian cells 
  • Development of biochemical high throughput and cellular drug screening assays crucial for the development of two widely used and highly specific PKC inhibitors, Goe6976 and Goe6815
  • Discovered mechanisms of crosstalk between protein kinase C and Raf pathways 
  • Co-discovered the crosstalk between the cAMP and Raf-1 signalling pathways


Recent Publications

The Ins and Outs of RAS Effector Complexes.
Kiel C, Matallanas D, Kolch W. Biomolecules. 2021 Feb 7;11(2):236. doi: 10.3390/biom11020236.PMID: 33562401

Signaling Dynamics Regulating Crosstalks between T-Cell Activation and Immune Checkpoints.
Kreileder M, Barrett I, Bendtsen C, Brennan D, Kolch W. Trends Cell Biol. 2021 Mar;31(3):224-235. doi: 10.1016/j.tcb.2020.12.001. Epub 2020 Dec 30.PMID: 33388215

Systems biology approaches to macromolecules: the role of dynamic protein assemblies in information processing. 
Rukhlenko O, Kholodenko BN, Kolch W.Curr Opin Struct Biol. 2021 Apr;67:61-68. doi: 10.1016/j.sbi.2020.09.007. Epub 2020 Oct 24.PMID: 33126139

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity.
Lee S, Rauch J, Kolch W.Int J Mol Sci. 2020 Feb 7;21(3):1102. doi: 10.3390/ijms21031102.PMID: 32046099

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Kennedy SA, Jarboui MA, Srihari S, Raso C, Bryan K, Dernayka L, Charitou T, Bernal-Llinares M, Herrera-Montavez C, Krstic A, Matallanas D, Kotlyar M, Jurisica I, Curak J, Wong V, Stagljar I, LeBihan T, Imrie L, Pillai P, Lynn MA, Fasterius E, Al-Khalili Szigyarto C, Breen J, Kiel C, Serrano L, Rauch N, Rukhlenko O, Kholodenko BN, Iglesias-Martinez LF, Ryan CJ, Pilkington R, Cammareri P, Sansom O, Shave S, Auer M, Horn N, Klose F, Ueffing M, Boldt K, Lynn DJ, Kolch W. Nat Commun. 2020 Jan 24;11(1):499. doi: 10.1038/s41467-019-14224-9.PMID: 31980649

 

See Also: 

Precision Oncology Ireland

COLOSSUS

BREAST-PREDICT

TOPMed10

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