Jens RauchAssistant Professor
Ashish NevePh.D. Student, Rauch Group
About the Group
What we do
Malignant melanoma is a skin cancer that is one of the deadliest cancers because of its tendency to spread rapidly and its resistance to drugs. The introduction of Raf inhibitors has profoundly changed the therapy of metastatic melanoma. However, despite impressive response rates resistance develops fast and frequently. Resistance is mainly due to network adaptations that bypass the drug blockade.
Our research focuses on elucidating the underlying mechanisms and the network adaptations of drug resistance in order to design personalized drug combinations that can avoid or overcome this resistance. In addition, we aim to derive diagnostic biomarkers that predict which drug combinations will be most effective for individual patients.
(For a complete list see Google Scholar)
Rukhlenko OR, Khorsand F, Rozanc J, Alexopoulos L, Rauch N, Hlavacek WS, Posner RG, Gómez-Coca S, Rosta E, Fitzgibbon C, Matallanas D, Rauch J, Kolch W, and Kholodenko BN. Dissecting RAF inhibitor resistance by structure-based dynamic modeling reveals drug combinations to overcome oncogenic RAS signaling to ERK. Cell Systems
Verlande A, Krafčíková M, Potěšil D, Trantírek L, Zdráhal Z, Elkalaf M, Trnka J, Souček K, Rauch N, Rauch J, Kolch W, Uldrijan S. Metabolic stress regulates ERK activity by controlling KSR-RAF heterodimerization. EMBO Reports
Pelosse M, Crocker H, Gorda B, Lemaire P, Rauch J, and Berger I (2017). MultiBac: from protein complex structures to synthetic viral nanosystems. BMC Biol 15, 2581. Review
Rauch, J., and Kolch, W. Spatial regulation of ARAF controls the MST2-Hippo pathway. (2017). Small Gtpases. Review
Fey D, Matallanas D, Rauch J, Rukhlenko OS, Kholodenko BN The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells. (2016) Semin Cell Dev Biol. Review
Baljuls A, Dobrzyński M, Rauch J, Rauch N and Kolch W Stabilization of C-RAF:KSR1 Complex by DiRas3 Reduces Availability of C-RAF for Dimerization with B-RAF Signalling (2016) Cellular Signaling
Bryan K, Jarboui M, Raso C, Bernal-Llinares M, McCann B, Rauch J, Boldt K and Lynn DJ HiQuant: Rapid Postquantification Analysis of Large-Scale MS-Generated Proteomics Data. (2016) Journal of Proteome Research
Rauch J, Van Damme D, Mack B, McCann B, Volinsky N, Blanco B, Gires O and Kolch W. Differential Localization of A-Raf Regulates MST2-mediated Apoptosis During Epithelial Differentiation. (2016) Cell Death and Differentiation
Farrell J, Kelly C, Rauch J, Kida K, García Muñoz A, Monsefi N, Turriziani B, Doherty C, Mehta JP, Matallansa D, Simpson J, Kolch W, and Von Kriegsheim A. HGF induces epithelial-to-mesenchymal transition by modulating the mammalian Hippo/MST2 and ISG15 pathways. (2014) Journal of Proteome Research