Bond Group

Childhood and Adolescent Leukaemia

Group Members

Jonathan Bond
Full Professor
Teerna Bhattacharyya
Postdoctoral Researcher, Bond Group
Sharmila Biswas
Postdoctoral Researcher, Bond Group
Sophie Carlin
AICRIstart Ph.D. Student, Ulster University/UCD, Matchett/Bond Groups
Ciardha Carmody
Ph.D. Student, Bond/Kolch Groups
Tânia Dias
Ph.D. Student, Bond Group
Marie-Claire Fitzgerald
Postdoctoral Researcher, Bond Group
Theodora Grosu
Ph.D. Student, Bond Group
Luke Jones
Postdoctoral Researcher, Bond Group
Peter McCarthy
Clinical Research Fellow and Ph.D. Student, Bond Group
Alanah McIntosh
Ph.D. Student, Kolch/Bond Groups
Amelie Trinquand
Clinical Biologist, Bond Group
Cosmin Tudose
Ph.D. Student, Bond/Ryan Groups

About the Group

The Bond Group uses systems biology approaches to investigate the molecular drivers of paediatric blood cancers, with a particular focus on epigenetics and network biology.

What we do:

Decades of research have enabled enormous advances in the treatment of children and adolescents with leukaemia, but there is still much room for improvement.

Thanks to modern high-throughput technologies like genomics, we now know more about the molecular landscape of blood cancers than ever before. However, analysing these complex data can be challenging, and needs close collaboration between clinicians, biologists, and computational scientists.

To address this, our group comprises expertise in leukaemia biology, medicine, bioinformatics, and computational research. We are co-located at the Irish National Children’s Cancer Service at Children’s Health Ireland at Crumlin and collaborate closely with international leukaemia research efforts across Europe. Working together, we aim to tackle the most pressing problems in paediatric blood cancer, and to find more precise and effective treatments for children and adolescents with these diseases.

Work with us:

PhD and post-doctoral positions are advertised on the SBI website and elsewhere, including social media channels. We are also interested in supporting independent funding applications by Irish and international candidates. For all enquiries, please contact Jonathan Bond by e-mail. 

 

 

For a full list of publications see https://people.ucd.ie/jonathan.bond/publications.

Recent Key Publications

Tudose C, Bond J, Ryan C. Gene essentiality in cancer is better predicted by mRNA abundance than by gene regulatory network-inferred activity. NAR Cancer. 2023;5(4): zcad056.

Bhattacharyya T, Bond J. Polycomb Alterations in Acute Myeloid Leukaemia: From Structure to Function. Cancers. 2023;15(6):1693.

Lefeivre T, Jones L, Trinquand A, Pinton A, Macintyre E, Laurenti E, Bond J. Immature acute leukaemias: lessons from the haematopoietic roadmap. FEBS J. 2022;289(15):4355-4370.

Bond, J, Krzywon, A, Lhermitte, L, Roumier, C, Roggy, A, Belhocine, M, Kheirallah, AK, Villarese, P, Hypolite, G, Garnache-Ottou, F, et al.. A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis. Leukemia. 2021 Mar;35(3):724-736.

Cordonnier G, Mandoli A, Cagnard N, Hypolite G, Lhermitte L, Verhoeyen E, Asnafi V, Dillon N, Macintyre E, Martens J, Bond J. CBFβ-SMMHC affects genome-wide Polycomb Repressive Complex 1 activity in Acute Myeloid Leukemia. Cell Reports 2020; 30, 299–307.

Jones L, McCarthy P, Bond J. Epigenetics of paediatric acute myeloid leukaemia. British Journal of Haematology. 2020;188(1):63-76. 

Bond J, Touzart A, Lepretre S, Graux C, Bargetzi M, Lhermitte L, Hypolite G, Leguay T, Hicheri Y, Guillerm G, Bilger K, Lheritier V, Hunault M, Huguet F, Chalandon Y, Ifrah N, Macintyre E, Dombret H, Asnafi V, Boissel N. DNMT3A mutation is associated with increased age and adverse outcome in adult T-acute lymphoblastic leukemia. Haematologica 2019 Aug;104(8):1617-1625

Yi G, Mandoli A, Jussen L, Tijchon E, van Bergen MGJM, Cordonnier G, Hansen M, Kim B, Nguyen LN, Jansen PWTC, Vermeulen M, van der Reijden B, van den Akker E, Bond J, Martens JHA. CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1. Blood Cancer Journal 2019 Mar 8;9(3):33.

Bond J, Labis E, Marceau-Renaut A, Duployez N, Labopin M, Hypolite G, Michel G, Ducassou S, Boutroux H, Nelken B, Bertrand Y, Baruchel A, Petit A, Asnafi V, Leverger G, Preudhomme C, Macintyre E, Lapillonne H. Polycomb Repressive Complex 2 haploinsufficiency identifies a high-risk subgroup of pediatric acute myeloid leukemia. Leukemia 2018 Aug;32(8):1878-1882.

Bond J, Graux C, Lhermitte L, Lara D, Cluzeau T, Leguay T, Cieslak A, Trinquand A, Pastoret C, Belhocine M, Spicuglia S, Lheritier V, Leprêtre S, Thomas X, Huguet F, Ifrah N, Dombret H, Macintyre E, Boissel N, Asnafi V. Early response-based therapy stratification improves survival in adult ETP-ALL: a GRAALL study. Journal of Clinical Oncology 2017 Aug 10;35(23):2683-2691.

Cordonnier G, Mandoli A, Radhouane A, Hypolite G, LhermitteL, Belhocine M, Asnafi V, Macintyre E, Martens J, Fumagalli S, Bond J. CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis. Leukemia 2017 Jun;31(6):1443-1446.

 

Links

Jonathan Bond on Twitter: https://twitter.com/jbond2019

"Bond Group Aims to 'Close the Gap' on Childhood Leukaemia in Tanzania," SBI news item, 16 April 2021: https://www.ucd.ie/sbi/news/newsfeatures/body,549089,en.html 

"Finding the cure: Immunotherapy offers hope to children battling cancer," Irish Examiner, 26 April 2019: https://www.irishexaminer.com/breakingnews/lifestyle/healthandlife/finding-the-cure-immunotherapy-offers-hope-to-children-battling-cancer-920302.html

"'We don't have enough funds to support them' - Irish Cancer Society can't afford life-saving research," Irish Examiner, 15 February 2019:  https://www.irishexaminer.com/breakingnews/ireland/we-dont-have-enough-funds-to-support-them--irish-cancer-society-cant-afford-life-saving-research-904750.html

"Blood, sweat and tears to survive cancer," Irish Examiner, 26 April 2018: https://www.irishexaminer.com/breakingnews/lifestyle/features/blood-sweat-and-tears-to-survive-cancer-839253.html

 

SBI blog posts

First ACORN event at Barretstown a great success - 11 May 2023

Young People at the Heart of Research: The unseen advocates working to revolutionise childhood cancer treatment - 4 February 2023

SBI helping to close the gap in global childhood cancer outcomes - 19 September 2022

The whimsical art of science research: Tales of a fantasy writer in a scientific world - 23 August 2022

A Day in the Life of a Medical Scientist - 15 October 2021

Notes on a Pandemic from a Clinician Scientist - 17 July 2020

A Drug by Any Other Name - 19 December 2019 

The French Connection at SBI: A Bastille Day Special - 12 July 2019 

New Prognostic Marker in Childhood and Adolescent Leukaemia - 17 July 2018 

Leukaemia Researcher Jonathan Bond Joins SBI as UCD 'Brendan McGonnell' Professor of Paediatric Molecular Haemato-Oncology - 5 April 2018 

 

 

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