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Charles Seminar Series 2021-22: Dynamic regulation of ERK1/2 MAPK signaling: implications for skin & other tissues, with guest speaker Dr Jürgen Muller, Wednesday 29th September at 12PM (In-Person at the Charles Institute Seminar Room & via Zoom)

Published: 28 September, 2021


Date of Talk: 29th September 2021 at 12PM

Location: Charles Seminar Room (In-Person PAX 25) & Online (via Zoom)

Talk TitleDynamic regulation of ERK1/2 MAPK signaling: implications for skin & other tissues

Speaker Details: Dr Jürgen Müller, University of Bradford     

Keywords: MAPK, RAS, Melanoma, Drug Resistance

Short Biography: Dr Müller received his PhD in Biochemistry from the Ruhr-Universität Bochum in Germany. He then undertook postdoctoral research at Columbia University, New York and The National Cancer Institute (NCI, NIH) in Maryland, USA, where he investigated the molecular mechanisms of gene regulation and associated signal transduction pathways. He continued these research themes as a group leader at the North West Cancer Research Institute in Bangor and as a Senior Lecturer / Associate Professor at Warwick and Aston Medical Schools, before joining the University of Bradford as a Reader. Dr Müller’s current research focuses on the dynamic regulation of cellular signalling, specifically the MAPK pathways. The goal of his research is to understand how cells maintain homeostasis under normal conditions, as well as the molecular mechanisms that underlie the development of disease.

Abstract for talk: The MAPK pathways are key cellular signaltransduction cascades that are central to the maintenance of homeostasis inhealthy cells. However, dysregulation of MAPK pathways contributes to thedevelopment and progression of many diseases, including malignant melanoma and othercancers. Re-wiring of MAPK signalling also determines the sensitivity of cancercells to targeted drug therapies and contributes to drug resistance mechanisms.Changes in MAPK signalling are also involved in the development of nevi, skinageing, squamous cell carcinoma, and a range of RASopathies affecting the skin and other organs.This talk will explore the signalling dynamics of the MAPK pathway and howthose mechanisms control the outcome of MAPK signalling. Implications fordisease progression and the development of drug resistance will also bediscussed.

If you are UCD-affiliated or a Consultant Dermatologist in Ireland and would like to register for this talk, please email