The Zeugolis Lab

Group Members

Dimitrios Zeugolis
Dimitrios Zeugolis
Principal Investigator
Alexandre Watigny
Alexandre Watigny
PhD Student
Laura Trujillo Cubillo
Laura Trujillo Cubillo
PhD Student

Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), The Zeugolis Lab

About The Zeugolis Lab:

REMODEL operates at the crossroads of engineering, chemistry, biology, medicine, entrepreneurship, humanities and social sciences, where education, research, innovation, social responsibility and clinical practice merge to improve human lives.

REMODEL works in the thematic area of wound healing &  develops, derisks and commercialises transformative and disruptive end-user informed advanced biomaterials, tissue engineered medicines and in vitro pathophysiology (e.g. fibrosis) models.

Keywords: Extracellular Matrix, Functional Biomaterials, Tissue Engineering, Regenerative Medicine, Advanced Therapy Medicinal Products, Medical Devices, Drug Discovery, Molecular Delivery, Cellular Agriculture / Aquaculture

Join our team

Prof Dimitrios Zeugolus invites suitably qualifiy candiates to apply for up to three PhD Scholarships (fully funded: fees and stipend) in his lab. Closing date is August 21st 2021. Please see here for more information.

To find out more about our research, to collaborate on a project or to discuss postdoc, PhD or internship opportunities, contact

Lab webpage:




Recent Publications
  1. De Pieri A, Rochev Y, Zeugolis DI. Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast. NPJ Regen Med. 2021 Mar 29;6(1):18 DOI: 10.1038/s41536-021-00133-3

  2. Capella-Monsonís H, Zeugolis DI. Decellularized xenografts in regenerative medicine: From processing to clinical application. Xenotransplantation. 2021 Mar 12:e12683. DOI:10.1111/xen.12683

  3. Capella-Monsonís H, De Pieri A, Peixoto R, Korntner S, Zeugolis DI. Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts. Stem Cell Res Ther. 2020 Nov 27;11(1):510 DOI: 10.1186/s13287-020-02021-x

  4. Tsiapalis D, De Pieri A, Spanoudes K, Sallent I, Kearns S, Kelly JL, Raghunath M, Zeugolis DI. The synergistic effect of low oxygen tension and macromolecular crowding in the development of extracellular matrix-rich tendon equivalents. Biofabrication. 2020 Feb 26;12(2):025018 DOI: 10.1088/1758-5090/ab6412

  5. Satyam A, Tsokos MG, Tresback JS, Zeugolis DI, Tsokos GC. Cell derived extracellular matrix-rich biomimetic substrate supports podocyte proliferation, differentiation and maintenance of native phenotype. Adv Funct Mater. 2020 Oct 28;30(44):1908752 DOI: 10.1002/adfm.201908752

  6. Gaspar D, Fuller KP, Zeugolis DI. Polydispersity and negative charge are key modulators of extracellular matrix deposition under macromolecular crowding conditions. Acta Biomater. 2019 Apr 1;88:197-210 DOI: 10.1016/j.actbio.2019.02.050

  7. Gaspar D, Ryan CNM, Zeugolis DI. Multifactorial bottom-up bioengineering approaches for the development of living tissue substitutes. FASEB J. 2019 Apr;33(4):5741-5754 DOI:10.1096/fj.201802451r

  8. Graceffa V, Vinatier C, Guicheux J, Stoddart M, Alini M, Zeugolis DI. Chasing Chimeras - The elusive stable chondrogenic phenotype. Biomaterials. 2019 Feb;192:199-225`DOI: DOI: 10.1016/j.biomaterials.2018.11.014

  9. Coentro JQ, Pugliese E, Hanley G, Raghunath M, Zeugolis DI. Current and upcoming therapies to modulate skin scarring and fibrosis. Adv Drug Deliv Rev. 2019 Jun;146:37-59 DOI:10.1016/j.addr.2018.08.009

  10. Sorushanova A, Delgado LM, Wu Z, Shologu N, Kshirsagar A, Raghunath R, Mullen AM, Bayon Y, Pandit A, Raghunath M, Zeugolis DI. The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development. Adv Mater. 2019 Jan;31(1):e1801651 DOI: 10.1002/adma.201801651