Project Title: Investigate the interaction of top-performing non-viral vectors for gene therapy within live system
Thematic Area: Rare Skin Diseases
Focus of Research: RDEB
Group Team members: Zhonglei He, Yinghao Li
Overview: Various methods for delivery of therapeutic nucleic acids have been developed in clinical and many pre-clinical studies. However, the underlying mechanisms of non-viral delivery methods remain unclear. The project will focus on the development of novel polymer-lipid nanoparticles which possess both potent transfection efficacy and high biocompatibility. Furthermore, the underlying mechanisms regarding targeted delivery, specific cell uptake and endosome escape will be investigated to complement the understanding of gene therapy and contribute to the rational design of non-viral vectors.
Funded by: Government of Ireland Postdoctoral Fellowship Programme PI: Prof. Wenxin Wang
Project Duration: September 2020- March 2021